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    Dlgap5 DLG associated protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 218977, updated on 28-Oct-2024

    Summary

    Official Symbol
    Dlgap5provided by MGI
    Official Full Name
    DLG associated protein 5provided by MGI
    Primary source
    MGI:MGI:2183453
    See related
    Ensembl:ENSMUSG00000037544 AllianceGenome:MGI:2183453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dlg7; Hurp; Dap-5; mKIAA0008
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Predicted to be located in cytosol and mitotic spindle. Predicted to be active in cytoplasm; nucleus; and spindle pole centrosome. Is expressed in hemolymphoid system gland; intestine; liver; and reproductive system. Orthologous to human DLGAP5 (DLG associated protein 5). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in liver E14 (RPKM 20.5), liver E14.5 (RPKM 17.2) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dlgap5 in Genome Data Viewer
    Location:
    14 C1; 14 24.6 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47625238..47655657, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (47387779..47418407, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52166 Neighboring gene lectin, galactose binding, soluble 3 Neighboring gene STARR-positive B cell enhancer ABC_E606 Neighboring gene ribosomal protein S15 pseudogene Neighboring gene F-box protein 34 Neighboring gene predicted gene, 35166

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    disks large-associated protein 5
    Names
    discs, large homolog 7
    discs, large homolog-associated protein 5
    hepatoma up-regulated protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424783.1NP_001411712.1  disks large-associated protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123665
      Related
      ENSMUSP00000153953.2, ENSMUST00000180299.8
    2. NM_001424784.1NP_001411713.1  disks large-associated protein 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123665
    3. NM_001424785.1NP_001411714.1  disks large-associated protein 5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC123665
    4. NM_144553.3NP_653136.2  disks large-associated protein 5 isoform 1

      See identical proteins and their annotated locations for NP_653136.2

      Status: VALIDATED

      Source sequence(s)
      AC123665
      Consensus CDS
      CCDS26987.1
      UniProtKB/TrEMBL
      A0A0R4J0G7, Q3UX88
      Related
      ENSMUSP00000040416.4, ENSMUST00000043296.10
      Conserved Domains (1) summary
      pfam03359
      Location:397543
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      47625238..47655657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001145949.1: Suppressed sequence

      Description
      NM_001145949.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears incompletely processed at its 3' end.