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    H2-T10 histocompatibility 2, T region locus 10 [ Mus musculus (house mouse) ]

    Gene ID: 15024, updated on 2-Nov-2024

    Summary

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    Official Symbol
    H2-T10provided by MGI
    Official Full Name
    histocompatibility 2, T region locus 10provided by MGI
    Primary source
    MGI:MGI:95942
    See related
    Ensembl:ENSMUSG00000079491 AllianceGenome:MGI:95942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H-2T10
    Summary
    Predicted to enable several functions, including beta-2-microglobulin binding activity; peptide antigen binding activity; and signaling receptor binding activity. Acts upstream of or within inner ear development. Predicted to be located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; lung; and musculoskeletal system. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to human HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-E (major histocompatibility complex, class I, E). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Broad expression in thymus adult (RPKM 27.5), spleen adult (RPKM 12.0) and 15 other tissues See more
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    Genomic context

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    See H2-T10 in Genome Data Viewer
    Location:
    17 B1; 17 18.93 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36426763..36432336, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36115871..36121444, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42486 Neighboring gene predicted gene, 54002 Neighboring gene histocompatibility 2, T region locus, pseudogene Neighboring gene ribosomal protein S6 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10950 Neighboring gene STARR-positive B cell enhancer ABC_E169 Neighboring gene histocompatibility-2, T region locus 25 Neighboring gene histocompatibility 2, T region pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The nature of major histocompatibility complex recognition by gamma delta T cells. Schild H, et al. Cell, 1994 Jan 14. PMID 8287478
    2. A population of murine gammadelta T cells that recognize an inducible MHC class Ib molecule. Crowley MP, et al. Science, 2000 Jan 14. PMID 10634788
    3. Role of a selecting ligand in shaping the murine γδ-TCR repertoire. Fahl SP, et al. Proc Natl Acad Sci U S A, 2018 Feb 20. PMID 29432160, Free PMC Article
    4. Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. Ito K, et al. Cell, 1990 Aug 10. PMID 2379238
    5. Functions of nonclassical MHC and non-MHC-encoded class I molecules. Braud VM, et al. Curr Opin Immunol, 1999 Feb. PMID 10047540

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables T cell receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TAP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-2-microglobulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables natural killer cell lectin-like receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inner ear development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MHC class I protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MHC class Ib protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histocompatibility 2, T region locus 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010395.7 → NP_034525.4  histocompatibility 2, T region locus 10 precursor

      See identical proteins and their annotated locations for NP_034525.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, coding) represents the coding allele found in NOD, 129, FVB/N, and other strains (PMID:2379238).
      Source sequence(s)
      AK088241, AK153876
      UniProtKB/TrEMBL
      Q861Q6, Q8WLM9
      Conserved Domains (2) summary
      cd07698
      Location:193 → 285
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:27 → 189
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RNA

    1. NR_046286.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, non-coding) represents the non-coding allele found in C57BL/6 (PMID:2379238).
      Source sequence(s)
      CT030728
      Related
      ENSMUST00000174625.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      36426763..36432336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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