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    fmo-4 Flavin-containing monooxygenase [ Caenorhabditis elegans ]

    Gene ID: 179845, updated on 2-Nov-2024

    Summary

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    Official Symbol
    fmo-4
    Official Full Name
    Flavin-containing monooxygenase
    Primary source
    WormBase:WBGene00001479
    Locus tag
    CELE_F53F4.5
    See related
    AllianceGenome:WB:WBGene00001479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable monooxygenase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in excretory system; hypodermis; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to several human genes including FMO2 (flavin containing dimethylaniline monoxygenase 2); FMO3 (flavin containing dimethylaniline monoxygenase 3); and FMO4 (flavin containing dimethylaniline monoxygenase 4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See fmo-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (13603276..13606701, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Minor capsid protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress. Hirani N, et al. Biol Open, 2016 May 15. PMID 27010030, Free PMC Article
    2. The fmo genes of Caenorhabditis elegans and C. briggsae: characterisation, gene expression and comparative genomic analysis. Petalcorin MI, et al. Gene, 2005 Feb 14. PMID 15716098
    3. The PH/MyTH4/FERM molecule MAX-1 inhibits UNC-5 activity in the regulation of VD growth cone protrusion in Caenorhabditis elegans. Mahadik SS, et al. Genetics, 2022 May 5. PMID 35348689, Free PMC Article
    4. Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases. Gujar MR, et al. PLoS Genet, 2017 Aug. PMID 28859089, Free PMC Article
    5. Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans. Shen C, et al. J Biol Chem, 2005 May 27. PMID 15781453

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD(P)H oxidase H2O2-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypotaurine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Flavin-containing monooxygenase
    NP_001256532.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13603276..13606701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269603.2 → NP_001256532.1  Flavin-containing monooxygenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256532.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDG8
      Conserved Domains (2) summary
      pfam00743
      Location:2 → 488
      FMO-like; Flavin-binding monooxygenase-like
      cl21454
      Location:4 → 209
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. NR_069899.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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