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    LSO2 Lso2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 1466460, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LSO2
    Official Full Name
    Lso2p
    Primary source
    SGD:S000028521
    Locus tag
    YGR169C-A
    See related
    AllianceGenome:SGD:S000028521; FungiDB:YGR169C-A; VEuPathDB:YGR169C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YGR169C-C
    Summary
    Enables ribosome binding activity. Involved in cellular response to nutrient; cytoplasmic translational elongation; and intracellular iron ion homeostasis. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See LSO2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (836387..836665, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Pex35p Neighboring gene pseudouridine synthase PUS6 Neighboring gene phosphatidylserine decarboxylase 2 Neighboring gene methionine--tRNA ligase MSM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lso2 is a conserved ribosome-bound protein required for translational recovery in yeast. Wang YJ, et al. PLoS Biol, 2018 Sep. PMID 30208026, Free PMC Article
    2. Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. Wells JN, et al. PLoS Biol, 2020 Jul. PMID 32687489, Free PMC Article
    3. The late-annotated small ORF LSO1 is a target gene of the iron regulon of Saccharomyces cerevisiae. An X, et al. Microbiologyopen, 2015 Dec. PMID 26450372, Free PMC Article
    4. A chemical potentiator of copper-accumulation used to investigate the iron-regulons of Saccharomyces cerevisiae. Foster AW, et al. Mol Microbiol, 2014 Jul. PMID 24895027, Free PMC Article
    5. Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii. Brachat S, et al. Genome Biol, 2003. PMID 12844361, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nutrient IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic translational elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lso2p
    NP_878080.3
    • Ribosome-associated protein; required for global translational elongation after recovery from stationary phase due to starvation; crosslinks to the 25S rRNA near the A site that overlaps the GTPase activation center, and to tRNAs; possible role in the iron deprivation response; localizes to the nucleus and cytoplasm, with enhanced nuclear localization under iron-replete conditions; null mutant exhibits slow growth during iron deprivation; orthologous to human CCDC124

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      836387..836665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184531.3 → NP_878080.3  TPA: Lso2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_878080.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUV3, Q3E772
      UniProtKB/TrEMBL
      A6ZUI0, B3LI61, C7GQ76, C8Z965, N1P603
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E772.1

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