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    PRDX2 peroxiredoxin 2 [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100172251, updated on 26-Mar-2024

    Summary

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    Gene symbol
    PRDX2
    Gene description
    peroxiredoxin 2
    Locus tag
    CR201_G0047861
    See related
    Ensembl:ENSPPYG00000009607
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs
    human mouse all
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    Genomic context

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    See PRDX2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 20 NC_072005.2 (12833371..12838538, complement)
    RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 19 NC_072004.1 (12853551..12859742, complement)

    Chromosome 20 - NC_072005.2Genomic Context describing neighboring genes Neighboring gene hook microtubule tethering protein 2 Neighboring gene JunB proto-oncogene, AP-1 transcription factor subunit Neighboring gene thrombospondin type 1 domain containing 8 Neighboring gene ribonuclease H2 subunit A Neighboring gene uncharacterized LOC129051893 Neighboring gene retbindin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp468O2412

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables thioredoxin peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hydrogen peroxide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in leukocyte activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxiredoxin-2
    Names
    thioredoxin-dependent peroxiredoxin 2
    NP_001125349.1
    XP_009251113.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131877.2 → NP_001125349.1  peroxiredoxin-2

      See identical proteins and their annotated locations for NP_001125349.1

      Status: PROVISIONAL

      Source sequence(s)
      CR858417
      UniProtKB/Swiss-Prot
      Q5RC63
      Related
      ENSPPYP00000010771.1, ENSPPYT00000011193.2
      Conserved Domains (2) summary
      cd03015
      Location:8 → 170
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
      pfam00578
      Location:8 → 141
      AhpC-TSA; AhpC/TSA family

    RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Genomic

    1. NC_072005.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

      Range
      12833371..12838538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009252838.4 → XP_009251113.1  peroxiredoxin-2 isoform X1

      UniProtKB/TrEMBL
      A0A6D2WV69
      Conserved Domains (1) summary
      cd03015
      Location:8 → 179
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RC63.3 GenPept UniProtKB/Swiss-Prot:Q5RC63

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