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    Trappc2b trafficking protein particle complex 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100910318, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Trappc2bprovided by RGD
    Official Full Name
    trafficking protein particle complex 2Bprovided by RGD
    Primary source
    RGD:6499350
    See related
    EnsemblRapid:ENSRNOG00000049062 AllianceGenome:RGD:6499350
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in X-linked spondyloepiphyseal dysplasia tarda. Orthologous to human TRAPPC2 (trafficking protein particle complex subunit 2) and TRAPPC2B (trafficking protein particle complex subunit 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 154.0), Thymus (RPKM 118.1) and 9 other tissues See more
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    Genomic context

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    See Trappc2b in Genome Data Viewer
    Location:
    10q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (36439185..36443432, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (35938225..35942869, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35036176..35040918, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095096 Neighboring gene Nedd4 binding protein 3 Neighboring gene SEC24 homolog A, COPII coat complex component Neighboring gene secretion associated, Ras related GTPase 1B Neighboring gene small nuclear ribonucleoprotein F-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    trafficking protein particle complex subunit 2B
    Names
    sedlin-like
    trafficking protein particle complex 2
    trafficking protein particle complex subunit 2
    trafficking protein particle complex subunit 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271111.1 → NP_001258040.1  trafficking protein particle complex subunit 2B

      See identical proteins and their annotated locations for NP_001258040.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      D3ZVF4
      Related
      ENSRNOP00000066171.1, ENSRNOT00000073738.4
      Conserved Domains (1) summary
      pfam04628
      Location:9 → 136
      Sedlin_N; Sedlin, N-terminal conserved region

    2. NM_001271112.1 → NP_001258041.1  trafficking protein particle complex subunit 2B

      See identical proteins and their annotated locations for NP_001258041.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      D3ZVF4
      Conserved Domains (1) summary
      pfam04628
      Location:9 → 136
      Sedlin_N; Sedlin, N-terminal conserved region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      36439185..36443432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZVF4.1 GenPept UniProtKB/Swiss-Prot:D3ZVF4

    Gene LinkOut

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