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    Muc20 mucin 20 [ Mus musculus (house mouse) ]

    Gene ID: 224116, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Muc20provided by MGI
    Official Full Name
    mucin 20provided by MGI
    Primary source
    MGI:MGI:2385039
    See related
    Ensembl:ENSMUSG00000035638 AllianceGenome:MGI:2385039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity. Acts upstream of or within hepatocyte growth factor receptor signaling pathway and positive regulation of MAPK cascade. Predicted to be located in basal plasma membrane; cytosol; and mitochondrial outer membrane. Is expressed in lung; metanephros; and submandibular gland. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human MUC20 (mucin 20, cell surface associated). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 9.0), colon adult (RPKM 3.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Muc20 in Genome Data Viewer
    Location:
    16 B3; 16 23.34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32597793..32617805, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32777419..32797435, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40674 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene mucin 4 Neighboring gene predicted gene, 34825 Neighboring gene predicted gene, 53949 Neighboring gene STARR-seq mESC enhancer starr_40675 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32813070-32813253 Neighboring gene STARR-seq mESC enhancer starr_40677 Neighboring gene somatomedin B domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_40678 Neighboring gene RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein Neighboring gene VISTA enhancer mm1352 Neighboring gene forty-two-three domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney. Higuchi T, et al. J Biol Chem, 2004 Jan 16. PMID 14565953
    2. FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells. Jones MR, et al. Cell Mol Life Sci, 2022 Nov 29. PMID 36445537, Free PMC Article
    3. MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. Higuchi T, et al. Mol Cell Biol, 2004 Sep. PMID 15314156, Free PMC Article
    4. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
    5. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that MUC20 is a novel regulator of the Met signaling cascade which has a role in suppression of the Grb2-Ras pathway.
      Title: MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31081

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hepatocyte growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hepatocyte growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mucin-20
    Names
    MUC-20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145874.1 → NP_001139346.1  mucin-20 isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK142548, AK165477, BB615450, MG954261
      Consensus CDS
      CCDS49829.1
      UniProtKB/TrEMBL
      E9PUF1
      Related
      ENSMUSP00000110769.2, ENSMUST00000115116.8
      Conserved Domains (1) summary
      PRK11907
      Location:151 → 266
      PRK11907; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed

    2. NM_146071.2 → NP_666183.2  mucin-20 isoform b precursor

      See identical proteins and their annotated locations for NP_666183.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK165477, BB661244
      Consensus CDS
      CCDS49830.1
      UniProtKB/Swiss-Prot
      Q76I84, Q8BUE7, Q8R0X0
      Related
      ENSMUSP00000041221.9, ENSMUST00000041123.9
      Conserved Domains (1) summary
      pfam05687
      Location:174 → 234
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      32597793..32617805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BUE7.1 GenPept UniProtKB/Swiss-Prot:Q8BUE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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