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    YPEL4 yippee like 4 [ Homo sapiens (human) ]

    Gene ID: 219539, updated on 2-Nov-2024

    Summary

    Official Symbol
    YPEL4provided by HGNC
    Official Full Name
    yippee like 4provided by HGNC
    Primary source
    HGNC:HGNC:18328
    See related
    Ensembl:ENSG00000166793 MIM:609725; AllianceGenome:HGNC:18328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable metal ion binding activity. Predicted to act upstream of or within several processes, including negative regulation of erythrocyte clearance; negative regulation of erythrocyte differentiation; and protein localization to plasma membrane. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 4.8), bone marrow (RPKM 3.2) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See YPEL4 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57645087..57649912, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57595261..57603883, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57412560..57417385, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene serpin family G member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3353 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57406889-57407468 Neighboring gene MIR130A host gene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57410743-57411242 Neighboring gene microRNA 130a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4727 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57435387-57436026 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57436027-57436664 Neighboring gene cleavage factor polyribonucleotide kinase subunit 1 Neighboring gene zinc finger DHHC-type palmitoyltransferase 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    Phenotypes

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    General gene information

    Clone Names

    • FLJ30213, MGC102723, MGC138324

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding  
    Component Evidence Code Pubs
    located_in nucleolus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363487.2NP_001350416.1  protein yippee-like 4

      Status: VALIDATED

      Source sequence(s)
      AP000662
      Consensus CDS
      CCDS7963.1
      UniProtKB/Swiss-Prot
      B3KW92, Q2M3U7, Q65Z98, Q96NS1
      UniProtKB/TrEMBL
      B3KNT4
      Conserved Domains (1) summary
      cl13152
      Location:28118
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
    2. NM_145008.3NP_659445.1  protein yippee-like 4

      See identical proteins and their annotated locations for NP_659445.1

      Status: VALIDATED

      Source sequence(s)
      AB098738
      Consensus CDS
      CCDS7963.1
      UniProtKB/Swiss-Prot
      B3KW92, Q2M3U7, Q65Z98, Q96NS1
      UniProtKB/TrEMBL
      B3KNT4
      Related
      ENSP00000300022.3, ENST00000300022.8
      Conserved Domains (1) summary
      cl13152
      Location:28118
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      57645087..57649912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426531.1XP_047282487.1  protein yippee-like 4 isoform X1

      UniProtKB/Swiss-Prot
      B3KW92, Q2M3U7, Q65Z98, Q96NS1
      Related
      ENSP00000432648.1, ENST00000524669.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      57595261..57603883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367978.1XP_054223953.1  protein yippee-like 4 isoform X1

      UniProtKB/Swiss-Prot
      B3KW92, Q2M3U7, Q65Z98, Q96NS1
    2. XM_054367977.1XP_054223952.1  protein yippee-like 4 isoform X2

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