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    ZFP91 ZFP91 zinc finger protein, atypical E3 ubiquitin ligase [ Homo sapiens (human) ]

    Gene ID: 80829, updated on 3-Nov-2024

    Summary

    Official Symbol
    ZFP91provided by HGNC
    Official Full Name
    ZFP91 zinc finger protein, atypical E3 ubiquitin ligaseprovided by HGNC
    Primary source
    HGNC:HGNC:14983
    See related
    Ensembl:ENSG00000186660 MIM:619289; AllianceGenome:HGNC:14983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PZF; DSM8; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757
    Summary
    The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]
    Expression
    Broad expression in testis (RPKM 63.1), bone marrow (RPKM 24.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See ZFP91 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (58579063..58621550)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (58528573..58571048)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58346536..58389023)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369313 Neighboring gene Sharpr-MPRA regulatory region 15251 Neighboring gene olfactory receptor family 5 subfamily B member 21 Neighboring gene leupaxin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4737 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58345528-58346220 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:58346914-58347605 Neighboring gene ZFP91-CNTF readthrough (NMD candidate) Neighboring gene ciliary neurotrophic factor Neighboring gene NANOG hESC enhancer GRCh37_chr11:58419172-58419673 Neighboring gene NANOG hESC enhancer GRCh37_chr11:58420305-58420859 Neighboring gene glycine-N-acyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat is identified to have a physical interaction with zinc finger protein 91 homolog (ZFP91) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Clone Names

    • FLJ57065

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding  
    enables protein binding PubMed 
    enables ubiquitin-protein transferase activity PubMed 
    Component Evidence Code Pubs
    located_in nucleolus  
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ZFP91
    Names
    RING-type E3 ubiquitin transferase ZFP91
    drug resistance-associated sequence in melanoma 8
    penta zinc finger protein
    zinc finger protein 757
    zinc finger protein 91 homolog
    zinc finger protein homologous to Zfp91 in mouse
    NP_001183980.1
    NP_444251.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197051.2NP_001183980.1  E3 ubiquitin-protein ligase ZFP91 isoform 2

      See identical proteins and their annotated locations for NP_001183980.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      AB056107, AI687439, AP001350, BC051743, BP219969
      Conserved Domains (2) summary
      sd00017
      Location:346365
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:400421
      zf-C2H2; Zinc finger, C2H2 type
    2. NM_053023.5NP_444251.1  E3 ubiquitin-protein ligase ZFP91 isoform 1

      See identical proteins and their annotated locations for NP_444251.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB056107, AI687439, AP001350, BC051743, BP219969
      Consensus CDS
      CCDS31553.1
      UniProtKB/Swiss-Prot
      A6NHC4, A8MSG7, Q86V47, Q96JP4, Q96JP5, Q96QA3
      Related
      ENSP00000339030.5, ENST00000316059.7
      Conserved Domains (2) summary
      sd00017
      Location:347366
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:401422
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      58579063..58621550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      58528573..58571048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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