Slc8a1 solute carrier family 8 member A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Slc8a1provided by RGD
Full Name: solute carrier family 8 member A1provided by RGD
Primary source: RGD:3717
See related: Ensembl:ENSRNOG00000008479 AllianceGenome:RGD:3717
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ncx; Ncx1
Summary: Enables calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration; calcium:sodium antiporter activity; and ion antiporter activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including metal ion transport; regulation of heart contraction; and response to purine-containing compound. Located in several cellular components, including T-tubule; Z disc; and dendrite. Is integral component of postsynaptic membrane. Used to study brain ischemia. Biomarker of brain ischemia; congestive heart failure; hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 418.6), Brain (RPKM 329.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (18975498..19299704)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (13194609..13547369)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (4244076..4564262, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy.
Title: Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy.
Abnormal expression and role of MicroRNA-214-3p/SLC8A1 in neonatal Hypoxic-Ischaemic encephalopathy.
Title: Abnormal expression and role of MicroRNA-214-3p/SLC8A1 in neonatal Hypoxic-Ischaemic encephalopathy.
Na(+)/Ca(2+) exchanger isoform 1 takes part to the Ca(2+)-related prosurvival pathway of SOD1 in primary motor neurons exposed to beta-methylamino-L-alanine.
Title: Na(+)/Ca(2+) exchanger isoform 1 takes part to the Ca(2+)-related prosurvival pathway of SOD1 in primary motor neurons exposed to beta-methylamino-L-alanine.
Increased transient receptor potential canonical 3 activity is involved in the pathogenesis of detrusor overactivity by dynamic interaction with Na(+)/Ca(2+) exchanger 1.
Title: Increased transient receptor potential canonical 3 activity is involved in the pathogenesis of detrusor overactivity by dynamic interaction with Na(+)/Ca(2+) exchanger 1.
Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons.
Title: Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons.
CircSLC8A1 and circNFIX can be used as auxiliary diagnostic markers for sudden cardiac death caused by acute ischemic heart disease.
Title: CircSLC8A1 and circNFIX can be used as auxiliary diagnostic markers for sudden cardiac death caused by acute ischemic heart disease.
The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke.
Title: The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke.
NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model.
Title: NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model.
Nuclear Factor-kappaB Increases Intracellular Calcium by Upregulation of Na+-Ca2+ Exchanger 1 in Cerulein-Induced Acute Pancreatitis.
Title: Nuclear Factor-κB Increases Intracellular Calcium by Upregulation of Na+-Ca2+ Exchanger 1 in Cerulein-Induced Acute Pancreatitis.
possible role of Ca2+ entry mode in the neurotransmitter ATP-induced Ca2+ signalling in the esophageal myenteric neurons
Title: Na(+) /Ca(2+) exchanger 1 is a key mechanosensitive molecule of the esophageal myenteric neurons.

Submit: New GeneRIF Correction See all GeneRIFs (106)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC20271P1 (e-PCR)
- UniSTS:271894

RH128952 (e-PCR)
- UniSTS:212260

UniSTS:239208 (e-PCR)
- UniSTS:239208

Slc8a1 (e-PCR), detects polymorphism
- UniSTS:239208

Slc8a1 (e-PCR), detects polymorphism
- UniSTS:243332

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ankyrin binding	IEA Inferred from Electronic Annotation more info
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
enables calcium:sodium antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium:sodium antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium:sodium antiporter activity	IEA Inferred from Electronic Annotation more info
enables calcium:sodium antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium:sodium antiporter activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion export	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion export	ISO Inferred from Sequence Orthology more info
involved_in calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in calcium ion transport into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cell communication	IEA Inferred from Electronic Annotation more info
involved_in cell communication by electrical coupling involved in cardiac conduction	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to caffeine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic placenta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular sodium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of the force of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in relaxation of smooth muscle	ISO Inferred from Sequence Orthology more info
involved_in response to ATP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle stretch	IEA Inferred from Electronic Annotation more info
involved_in response to muscle stretch	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in sodium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in telencephalon development	IEP Inferred from Expression Pattern more info	PubMed
involved_in vascular associated smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in T-tubule	TAS Traceable Author Statement more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/calcium exchanger 1

Names: Na(+)/Ca(2+)-exchange protein 1; Na-Ca exchanger; solute carrier family 8 (sodium/calcium exchanger), member 1; solute carrier family 8 member 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270772.2 → NP_001257701.1 sodium/calcium exchanger 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001257701.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q01728, Q924Y2, Q9QW49, Q9R238, Q9R239, Q9WU29, Q9WU30

UniProtKB/TrEMBL

A6H9P2

Conserved Domains (1) summary

TIGR00845
Location:1 → 935

caca; sodium/calcium exchanger 1
NM_001270773.2 → NP_001257702.1 sodium/calcium exchanger 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001257702.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate second exon and lacks three alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I5XVV7, A6H9P6

Conserved Domains (5) summary

smart00237
Location:534 → 624

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

TIGR00845
Location:1 → 934

caca; sodium/calcium exchanger 1

pfam01699
Location:761 → 925

Na_Ca_ex; Sodium/calcium exchanger protein

pfam03160
Location:403 → 493

Calx-beta; Calx-beta domain

pfam16494
Location:251 → 381

Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
NM_001270774.2 → NP_001257703.1 sodium/calcium exchanger 1 isoform 4 precursor

See identical proteins and their annotated locations for NP_001257703.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q01728, Q924Y2, Q9QW49, Q9R238, Q9R239, Q9WU29, Q9WU30

UniProtKB/TrEMBL

A6H9P0

Conserved Domains (1) summary

TIGR00845
Location:1 → 958

caca; sodium/calcium exchanger 1
NM_001270775.2 → NP_001257704.1 sodium/calcium exchanger 1 isoform 5 precursor

See identical proteins and their annotated locations for NP_001257704.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) contains an alternate second exon and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I5ZXH4, A6H9P3

Related

ENSRNOP00000082575.1, ENSRNOT00000119744.1

Conserved Domains (1) summary

TIGR00845
Location:1 → 957

caca; sodium/calcium exchanger 1
NM_001270776.2 → NP_001257705.1 sodium/calcium exchanger 1 isoform 6 precursor

See identical proteins and their annotated locations for NP_001257705.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) contains an alternate second exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but has an alternate internal segment compared to variant 1.

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AXH4

Conserved Domains (5) summary

smart00237
Location:534 → 624

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

TIGR00845
Location:1 → 969

caca; sodium/calcium exchanger 1

pfam01699
Location:796 → 960

Na_Ca_ex; Sodium/calcium exchanger protein

pfam03160
Location:403 → 493

Calx-beta; Calx-beta domain

pfam16494
Location:251 → 381

Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
NM_001270777.2 → NP_001257706.1 sodium/calcium exchanger 1 isoform 7 precursor

See identical proteins and their annotated locations for NP_001257706.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) contains an alternate second exon and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I5ZXH4

Related

ENSRNOP00000043539.4, ENSRNOT00000046246.6

Conserved Domains (5) summary

smart00237
Location:534 → 624

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

TIGR00845
Location:1 → 962

caca; sodium/calcium exchanger 1

pfam01699
Location:789 → 953

Na_Ca_ex; Sodium/calcium exchanger protein

pfam03160
Location:403 → 493

Calx-beta; Calx-beta domain

pfam16494
Location:251 → 381

Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
NM_001270778.2 → NP_001257707.1 sodium/calcium exchanger 1 isoform 8 precursor

See identical proteins and their annotated locations for NP_001257707.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) contains an alternate second exon and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (8) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AXH4, A0A8L2QNY8

Related

ENSRNOP00000044094.5, ENSRNOT00000043870.6

Conserved Domains (5) summary

smart00237
Location:534 → 624

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

TIGR00845
Location:1 → 964

caca; sodium/calcium exchanger 1

pfam01699
Location:791 → 955

Na_Ca_ex; Sodium/calcium exchanger protein

pfam03160
Location:403 → 493

Calx-beta; Calx-beta domain

pfam16494
Location:251 → 381

Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
NM_001270779.2 → NP_001257708.1 sodium/calcium exchanger 1 isoform 9 precursor

See identical proteins and their annotated locations for NP_001257708.1

Status: VALIDATED

Description

Transcript Variant: This variant (9) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (9) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q01728, Q924Y2, Q9QW49, Q9R238, Q9R239, Q9WU29, Q9WU30

UniProtKB/TrEMBL

A0A8L2QK59

Related

ENSRNOP00000040765.5, ENSRNOT00000042251.6

Conserved Domains (5) summary

smart00237
Location:534 → 624

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

TIGR00845
Location:1 → 965

caca; sodium/calcium exchanger 1

pfam01699
Location:792 → 956

Na_Ca_ex; Sodium/calcium exchanger protein

pfam03160
Location:403 → 493

Calx-beta; Calx-beta domain

pfam16494
Location:251 → 381

Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
NM_019268.4 → NP_062141.3 sodium/calcium exchanger 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_062141.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q01728, Q924Y2, Q9QW49, Q9R238, Q9R239, Q9WU29, Q9WU30

UniProtKB/TrEMBL

A6H9N8

Related

ENSRNOP00000064030.3, ENSRNOT00000070918.4

Conserved Domains (1) summary

TIGR00845
Location:1 → 970

caca; sodium/calcium exchanger 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

18975498..19299704

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111865.2 → XP_038967793.1 sodium/calcium exchanger 1 isoform X1

UniProtKB/Swiss-Prot

Q01728, Q924Y2, Q9QW49, Q9R238, Q9R239, Q9WU29, Q9WU30

Conserved Domains (1) summary

TIGR00845
Location:19 → 988

caca; sodium/calcium exchanger 1
XM_039111867.2 → XP_038967795.1 sodium/calcium exchanger 1 isoform X3

UniProtKB/Swiss-Prot

Q01728, Q924Y2, Q9QW49, Q9R238, Q9R239, Q9WU29, Q9WU30

Conserved Domains (1) summary

TIGR00845
Location:19 → 983

caca; sodium/calcium exchanger 1
XM_039111878.2 → XP_038967806.1 sodium/calcium exchanger 1 isoform X9

UniProtKB/Swiss-Prot

Q01728, Q924Y2, Q9QW49, Q9R238, Q9R239, Q9WU29, Q9WU30

Conserved Domains (1) summary

TIGR00845
Location:19 → 960

caca; sodium/calcium exchanger 1
XM_039111869.2 → XP_038967797.1 sodium/calcium exchanger 1 isoform X5

UniProtKB/Swiss-Prot

Q01728, Q924Y2, Q9QW49, Q9R238, Q9R239, Q9WU29, Q9WU30

Conserved Domains (1) summary

TIGR00845
Location:19 → 981

caca; sodium/calcium exchanger 1
XM_039111871.2 → XP_038967799.1 sodium/calcium exchanger 1 isoform X7

UniProtKB/Swiss-Prot

Q01728, Q924Y2, Q9QW49, Q9R238, Q9R239, Q9WU29, Q9WU30

Conserved Domains (1) summary

TIGR00845
Location:19 → 976

caca; sodium/calcium exchanger 1
XM_039111884.2 → XP_038967812.1 sodium/calcium exchanger 1 isoform X11

UniProtKB/Swiss-Prot

Q01728, Q924Y2, Q9QW49, Q9R238, Q9R239, Q9WU29, Q9WU30

Conserved Domains (1) summary

TIGR00845
Location:19 → 953

caca; sodium/calcium exchanger 1
XM_039111866.2 → XP_038967794.1 sodium/calcium exchanger 1 isoform X2

UniProtKB/TrEMBL

A0A8I6AXH4

Conserved Domains (1) summary

TIGR00845
Location:19 → 987

caca; sodium/calcium exchanger 1
XM_039111868.2 → XP_038967796.1 sodium/calcium exchanger 1 isoform X4

UniProtKB/TrEMBL

A0A8I6AXH4

Conserved Domains (1) summary

TIGR00845
Location:19 → 982

caca; sodium/calcium exchanger 1
XM_039111879.2 → XP_038967807.1 sodium/calcium exchanger 1 isoform X10

UniProtKB/TrEMBL

A0A8I5XVV7

Conserved Domains (1) summary

TIGR00845
Location:19 → 959

caca; sodium/calcium exchanger 1
XM_039111870.2 → XP_038967798.1 sodium/calcium exchanger 1 isoform X6

UniProtKB/TrEMBL

A0A8I5ZXH4

Conserved Domains (1) summary

TIGR00845
Location:19 → 980

caca; sodium/calcium exchanger 1
XM_039111872.2 → XP_038967800.1 sodium/calcium exchanger 1 isoform X8

UniProtKB/TrEMBL

A0A8I5ZXH4

Conserved Domains (1) summary

TIGR00845
Location:19 → 975

caca; sodium/calcium exchanger 1
XM_039111885.2 → XP_038967813.1 sodium/calcium exchanger 1 isoform X12

UniProtKB/TrEMBL

A0A8I5XVV7

Conserved Domains (1) summary

TIGR00845
Location:19 → 952

caca; sodium/calcium exchanger 1
XM_039111887.2 → XP_038967815.1 sodium/calcium exchanger 1 isoform X15

Conserved Domains (1) summary

TIGR00845
Location:19 → 657

caca; sodium/calcium exchanger 1
XM_063261595.1 → XP_063117665.1 sodium/calcium exchanger 1 isoform X15
XM_039111888.2 → XP_038967816.1 sodium/calcium exchanger 1 isoform X15

Conserved Domains (1) summary

TIGR00845
Location:19 → 657

caca; sodium/calcium exchanger 1
XM_039111889.2 → XP_038967817.1 sodium/calcium exchanger 1 isoform X16

Conserved Domains (1) summary

TIGR00845
Location:19 → 618

caca; sodium/calcium exchanger 1
XM_039111886.2 → XP_038967814.1 sodium/calcium exchanger 1 isoform X13

UniProtKB/Swiss-Prot

Q01728, Q924Y2, Q9QW49, Q9R238, Q9R239, Q9WU29, Q9WU30

UniProtKB/TrEMBL

A6H9P2

Conserved Domains (1) summary

TIGR00845
Location:1 → 935

caca; sodium/calcium exchanger 1
XM_039111880.2 → XP_038967808.1 sodium/calcium exchanger 1 isoform X14

UniProtKB/Swiss-Prot

Q01728, Q924Y2, Q9QW49, Q9R238, Q9R239, Q9WU29, Q9WU30

UniProtKB/TrEMBL

A6H9P0

Related

ENSRNOP00000050918.4

Conserved Domains (1) summary

TIGR00845
Location:1 → 958

caca; sodium/calcium exchanger 1
XM_063261596.1 → XP_063117666.1 sodium/calcium exchanger 1 isoform X17
XM_063261597.1 → XP_063117667.1 sodium/calcium exchanger 1 isoform X18