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    Cdh15 cadherin 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361432, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cdh15provided by RGD
    Official Full Name
    cadherin 15provided by RGD
    Primary source
    RGD:1303000
    See related
    EnsemblRapid:ENSRNOG00000027954 AllianceGenome:RGD:1303000
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to be located in Golgi apparatus; caveola; and neuromuscular junction. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 3. Orthologous to human CDH15 (cadherin 15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 66.4), Brain (RPKM 45.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdh15 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (67812169..67834986)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50903757..50927151)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55669661..55689986)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483402 Neighboring gene uncharacterized LOC108348960 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene acyl-CoA synthetase family member 3 Neighboring gene ankyrin repeat domain containing 11 Neighboring gene small nucleolar RNA U3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Retinal selectivity of gene expression in rat retinal versus brain capillary endothelial cell lines by differential display analysis. Tomi M, et al. Mol Vis, 2004 Aug 9. PMID 15316464
    2. Modulation of satellite cells activity and MyoD in rat thyroarytenoid muscle after reinnervation. Kodama H, et al. Laryngoscope, 2015 Jul. PMID 25809587
    3. Alterations of M-cadherin, neural cell adhesion molecule and beta-catenin expression in satellite cells during overload-induced skeletal muscle hypertrophy. Ishido M, et al. Acta Physiol (Oxf), 2006 Jul. PMID 16776666
    4. Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells. Donalies M, et al. Proc Natl Acad Sci U S A, 1991 Sep 15. PMID 1840697, Free PMC Article
    5. Modulation of myoblast fusion by caveolin-3 in dystrophic skeletal muscle cells: implications for Duchenne muscular dystrophy and limb-girdle muscular dystrophy-1C. Volonte D, et al. Mol Biol Cell, 2003 Oct. PMID 14517320, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NMJ formation following reinnervation might prompt recovery of M-cadherin and MyoD mRNA expression to the quiescent level of SCs
      Title: Modulation of satellite cells activity and MyoD in rat thyroarytenoid muscle after reinnervation.
    2. Results suggested that the expressions of NCAM, M-cadherin and beta-catenin in skeletal muscle satellite cells may be controlled by distinct regulatory mechanisms during functional overload and muscle hypertrophy.
      Title: Alterations of M-cadherin, neural cell adhesion molecule and beta-catenin expression in satellite cells during overload-induced skeletal muscle hypertrophy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-15
    Names
    M-cadherin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207613.1 → NP_997496.1  cadherin-15 precursor

      See identical proteins and their annotated locations for NP_997496.1

      Status: PROVISIONAL

      Source sequence(s)
      AB176538
      UniProtKB/TrEMBL
      A0A8J8YP12, F1LQ16, Q75NI5
      Related
      ENSRNOP00000034685.6, ENSRNOT00000033352.7
      Conserved Domains (3) summary
      cd11304
      Location:155 → 255
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam00028
      Location:270 → 366
      Cadherin; Cadherin domain
      pfam01049
      Location:639 → 782
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      67812169..67834986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097879.2 → XP_038953807.1  cadherin-15 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AM66, A0A8J8YP12
      Related
      ENSRNOP00000094457.1, ENSRNOT00000109297.2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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