APOE apolipoprotein E [Sus scrofa (pig)] - Gene

Summary

Official Symbol: APOEprovided by VGNC
Official Full Name: apolipoprotein Eprovided by VGNC
Primary source: VGNC:VGNC:103899
See related: Ensembl:ENSSSCG00000003088
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Annotation information: Annotation category: partial on reference assembly
Expression: Biased expression in liver (RPKM 11038.8), mixtures (RPKM 4229.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (51373113..51375333)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	6	NC_010448.3 (47269973..47272195)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Title: A functional mutation at position -155 in porcine APOE promoter affects gene expression.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables very-low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cholesterol catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipoprotein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of nitric-oxide synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of amyloid-beta clearance	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
part_of intermediate-density lipoprotein particle	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: apolipoprotein E

Names: apo-E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.