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    Mcam melanoma cell adhesion molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 78967, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Mcamprovided by RGD
    Official Full Name
    melanoma cell adhesion moleculeprovided by RGD
    Primary source
    RGD:620463
    See related
    EnsemblRapid:ENSRNOG00000007726 AllianceGenome:RGD:620463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CD146; Muc18
    Summary
    Involved in positive regulation of cell migration. Located in extracellular space and nucleus. Biomarker of impotence and malignant mesothelioma. Orthologous to human MCAM (melanoma cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 474.8), Heart (RPKM 232.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mcam in Genome Data Viewer
    Location:
    8q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53376225..53384407)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44479391..44487575)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48472824..48481005)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094132 Neighboring gene ring finger protein 26 Neighboring gene Cbl proto-oncogene Neighboring gene dynein regulatory complex subunit 12 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4. Marr N, et al. Int J Mol Sci, 2021 Sep 8. PMID 34575887, Free PMC Article
    2. Menstrual blood CD146(+) mesenchymal stem cells reduced fibrosis rate in the rat model of premature ovarian failure. Yamchi NN, et al. Cell Biochem Funct, 2021 Dec. PMID 34477225
    3. Expression of cell adhesion molecule, Gicerin/CD146 during the formation of heart and in the cardiac hypertrophy. Obara M, et al. Mol Cell Biochem, 2021 May. PMID 33515199
    4. Correction of diabetic erectile dysfunction with adipose derived stem cells modified with the vascular endothelial growth factor gene in a rodent diabetic model. Liu G, et al. PLoS One, 2013. PMID 24023647, Free PMC Article
    5. Involvement of gicerin, a cell adhesion molecule, in the portal metastasis of rat colorectal adenocarcinoma cells. Adachi K, et al. Oncol Rep, 2010 Dec. PMID 21042736

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Menstrual blood CD146(+) mesenchymal stem cells reduced fibrosis rate in the rat model of premature ovarian failure.
      Title: Menstrual blood CD146(+) mesenchymal stem cells reduced fibrosis rate in the rat model of premature ovarian failure.
    2. CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-alpha4.
      Title: CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4.
    3. Expression of cell adhesion molecule, Gicerin/CD146 during the formation of heart and in the cardiac hypertrophy.
      Title: Expression of cell adhesion molecule, Gicerin/CD146 during the formation of heart and in the cardiac hypertrophy.
    4. Alterations in CD146 are involved in the basic etiology of COPD/pulmonary emphysema.
      Title: Endothelial cell adhesion molecule CD146: implications for its role in the pathogenesis of COPD.
    5. Gicerin might promote the interaction of tumor cells with a hepatic endothelium, thus leading to the hepatic metastasis of colon adenocarcinomas.
      Title: Involvement of gicerin, a cell adhesion molecule, in the portal metastasis of rat colorectal adenocarcinoma cells.
    6. Increase of gicerin expression by NGF promotes the gicerin-gicerin homophilic interaction resulting in the neurite extension.
      Title: Gicerin/CD146 is involved in neurite extension of NGF-treated PC12 cells.
    7. expression of gicerin was increased in the rat carotid arteries after balloon injury. Gicerin might be involved in the arteriosclerotic neointima formation in the artery.
      Title: Induction of gicerin/CD146 in the rat carotid artery after balloon injury.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vascular wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cell surface glycoprotein MUC18
    Names
    gicerin
    l-gicerin
    melanoma-associated antigen MUC18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034009.1 → NP_001029181.1  cell surface glycoprotein MUC18 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001029181.1

      Status: VALIDATED

      Source sequence(s)
      BC070916
      UniProtKB/TrEMBL
      A0A8I6AFJ0, A6J3W1
      Related
      ENSRNOP00000069860.1, ENSRNOT00000090780.3
      Conserved Domains (4) summary
      pfam08205
      Location:141 → 236
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:348 → 412
      Ig_3; Immunoglobulin domain
      cd00096
      Location:172 → 177
      Ig; Ig strand C [structural motif]
      cl11960
      Location:452 → 508
      Ig; Immunoglobulin domain

    2. NM_023983.3 → NP_076473.2  cell surface glycoprotein MUC18 isoform 1 precursor

      See identical proteins and their annotated locations for NP_076473.2

      Status: VALIDATED

      Source sequence(s)
      AB035506, BC070916
      UniProtKB/Swiss-Prot
      Q6IRH8, Q9EPF2, Q9ESS8
      UniProtKB/TrEMBL
      A0A8I6AFJ0, A6J3W0
      Related
      ENSRNOP00000010464.5, ENSRNOT00000010463.8
      Conserved Domains (4) summary
      smart00408
      Location:359 → 412
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:440 → 515
      IG_like; Immunoglobulin like
      pfam08205
      Location:141 → 236
      C2-set_2; CD80-like C2-set immunoglobulin domain
      cl11960
      Location:452 → 515
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53376225..53384407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPF2.2 GenPept UniProtKB/Swiss-Prot:Q9EPF2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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