Gadd45g growth arrest and DNA-damage-inducible, gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gadd45gprovided by RGD
Official Full Name: growth arrest and DNA-damage-inducible, gammaprovided by RGD
Primary source: RGD:1311796
See related: EnsemblRapid:ENSRNOG00000013090 AllianceGenome:RGD:1311796
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including positive regulation of MAPK cascade; positive regulation of apoptotic process; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within negative regulation of protein kinase activity and positive regulation of MAPK cascade. Predicted to be active in cytoplasm and nucleus. Biomarker of mesangial proliferative glomerulonephritis. Orthologous to human GADD45G (growth arrest and DNA damage inducible gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 128.0), Heart (RPKM 101.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (13528606..13530351, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (13376842..13378587, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (13391474..13393219, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
Title: MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
Report of sex differences in the expression of growth arrest and DNA damage inducible factor beta (Gadd45b), but not family members alpha (a) or gamma (g), in the neonatal and juvenile rodent amygdala
Title: Sex differences in Gadd45b expression and methylation in the developing rodent amygdala.
Gadd45 gamma gene expression is involved in regulating glomerular mesangial cell apoptosis mediated by sublytic C5b-9 in Thy-1 nephritis
Title: Apoptosis of glomerular mesangial cells induced by sublytic C5b-9 complexes in rats with Thy-1 nephritis is dependent on Gadd45 gamma upregulation.

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General gene information

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Markers

C86281 (e-PCR)
- UniSTS:160301

PMC86941P1 (e-PCR)
- UniSTS:273565

UniSTS:237015 (e-PCR)
- UniSTS:237015

NoName (e-PCR)
- UniSTS:546781

Gadd45g (e-PCR), detects polymorphism
- UniSTS:546781

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: growth arrest and DNA damage-inducible protein GADD45 gamma

Names: GADD45gamma; growth arrest and DNA damage inducible; growth arrest and DNA-damage-inducible 45 gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077640.2 → NP_001071108.1 growth arrest and DNA damage-inducible protein GADD45 gamma

See identical proteins and their annotated locations for NP_001071108.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q9WTQ7

UniProtKB/TrEMBL

B5DEF0

Related

ENSRNOP00000018251.4, ENSRNOT00000018252.9

Conserved Domains (1) summary

pfam01248
Location:24 → 106

Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family