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    CRTC3 CREB regulated transcription coactivator 3 [ Homo sapiens (human) ]

    Gene ID: 64784, updated on 14-Nov-2024

    Summary

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    Official Symbol
    CRTC3provided by HGNC
    Official Full Name
    CREB regulated transcription coactivator 3provided by HGNC
    Primary source
    HGNC:HGNC:26148
    See related
    Ensembl:ENSG00000140577 MIM:608986; AllianceGenome:HGNC:26148
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TORC3; TORC-3
    Summary
    This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 20.6), fat (RPKM 11.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CRTC3 in Genome Data Viewer
    Location:
    15q26.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (90529923..90645345)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (88285952..88401360)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91073155..91188577)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90938261-90938762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90938763-90939262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6820 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 4 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:90955563-90956294 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:90957593-90958792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10077 Neighboring gene IQ motif containing GTPase activating protein 1 Neighboring gene MPRA-validated peak2420 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr15:90999383-90999894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10078 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:91054233-91054732 Neighboring gene MPRA-validated peak2421 silencer Neighboring gene MPRA-validated peak2422 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91106113-91106613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6824 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:91126557-91127068 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:91127069-91127580 Neighboring gene uncharacterized LOC124903555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91137296-91137796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10080 Neighboring gene Sharpr-MPRA regulatory region 4613 Neighboring gene uncharacterized LOC124903554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10081 Neighboring gene CRTC3 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:91183956-91185155 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:91189835-91190018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10083 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91203621-91204149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6825 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6826 Neighboring gene long intergenic non-protein coding RNA 1585 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10089 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91226288-91226788 Neighboring gene small nucleolar RNA SNORD18 Neighboring gene BLM RecQ like helicase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Morphological and biological properties of silica nanoparticles for CRTC3-siRNA delivery and downregulation of the RGS2 expression in preadipocytes.
      Title: Morphological and biological properties of silica nanoparticles for CRTC3-siRNA delivery and downregulation of the RGS2 expression in preadipocytes.
    2. TORC2/3-mediated DUSP1 upregulation is essential for human decidualization.
      Title: TORC2/3-mediated DUSP1 upregulation is essential for human decidualization.
    3. Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance.
      Title: Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance.
    4. Pancreatic mucoepidermoid carcinoma does not have CRTC1/3-MAML2 fusion gene and MAML2 gene rearrangement.
      Title: "Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid Carcinoma of the Salivary Gland, and May More Appropriately be Termed Pancreatic Adenosquamous Carcinoma With Mucoepidermoid Carcinoma-like Features.
    5. CRTC3-MAML2 gene fusion occurs in hidradenomas.
      Title: A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance.
    6. CRTC3 polymorphism was associated with the onset of acute coronary syndrome in Han Chinese patients, which may be related to the imbalance of the lipid metabolism
      Title: Cyclic adenosine monophosphate-regulated transcriptional co-activator 3 polymorphism in Chinese patients with acute coronary syndrome.
    7. findings suggest further characterization of MECs is needed before considering the CRTC1/3-MAML2 gene fusion as a prognostic biomarker
      Title: Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma.
    8. revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma
      Title: Cutaneous hidradenoma: a study of 21 neoplasms revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions.
    9. The CRTC3 polymorphism rs3862434 is associated with the plasma level of total cholesterol, and rs11635252 is associated with the risks of overweight and hypertriglyceridemia in a Chinese Han population.
      Title: CRTC3 polymorphisms were associated with the plasma level of total cholesterol and the risks of overweight and hypertriglyceridemia in a Chinese Han population.
    10. Metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands did not harbor CRTC1-MAML2 and CRTC3-MAML2 fusion transcripts, respectively, or MAML2 gene rearrangement.
      Title: CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Whole genome association scan for genetic polymorphisms influencing information processing speed.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of CREB regulated transcription coactivator 3 (CRTC3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21868

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cAMP response element binding protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cAMP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in energy homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CREB-regulated transcription coactivator 3
    Names
    transducer of regulated CREB protein 3
    transducer of regulated cAMP response element-binding protein (CREB) 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047180.1 RefSeqGene

      Range
      5038..120460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042574.3 → NP_001036039.1  CREB-regulated transcription coactivator 3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' terminal exon compared to variant 1. It encodes isoform b which is shorter than isoform a.
      Source sequence(s)
      AI969212, AK025521, AK074170, AL360259, AY360173, BP238198, BP365179, DB288138, HY057135, HY109267
      Consensus CDS
      CCDS45348.1
      UniProtKB/TrEMBL
      Q8TEF4
      Related
      ENSP00000416573.2, ENST00000420329.6
      Conserved Domains (4) summary
      PHA03378
      Location:346 → 537
      PHA03378; EBNA-3B; Provisional
      pfam12884
      Location:11 → 64
      TORC_N; Transducer of regulated CREB activity, N-terminus
      pfam12885
      Location:159 → 319
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:545 → 618
      TORC_C; Transducer of regulated CREB activity, C-terminus

    2. NM_022769.5 → NP_073606.3  CREB-regulated transcription coactivator 3 isoform a

      See identical proteins and their annotated locations for NP_073606.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC021422, AI969212, AK074170, AL360259, AY360173, BP238198, BP365179, CN298837, DB288138, HY057135, HY109267
      Consensus CDS
      CCDS32331.1
      UniProtKB/Swiss-Prot
      Q6DK61, Q6DK62, Q6UUV7, Q8NF38, Q9H6U2
      UniProtKB/TrEMBL
      Q8TEF4
      Related
      ENSP00000268184.6, ENST00000268184.11
      Conserved Domains (4) summary
      PHA03378
      Location:346 → 537
      PHA03378; EBNA-3B; Provisional
      pfam12884
      Location:11 → 64
      TORC_N; Transducer of regulated CREB activity, N-terminus
      pfam12885
      Location:159 → 319
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:545 → 619
      TORC_C; Transducer of regulated CREB activity, C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      90529923..90645345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      88285952..88401360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UUV7.2 GenPept UniProtKB/Swiss-Prot:Q6UUV7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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