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    br broad-complex core protein [ Bombyx mori (domestic silkworm) ]

    Gene ID: 692523, updated on 10-Oct-2024

    Summary

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    Gene symbol
    br
    Gene description
    broad-complex core protein
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bombyx mori
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; Bombycidae; Bombycinae; Bombyx
    Also known as
    Br-c
    Orthologs
    fruit fly all
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    Genomic context

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    Location:
    chromosome: 8
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_01 current ASM3026992v2 (GCF_030269925.1) 8 NC_085114.1 (15276515..15459293)
    103 previous assembly Bmori_2016v1.0 (GCF_014905235.1) 8 NC_051365.1 (15243222..15426001)

    Chromosome 8 - NC_085114.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101744165 Neighboring gene uncharacterized LOC105843018 Neighboring gene uncharacterized LOC119628793 Neighboring gene transfer RNA leucine (anticodon UAA) Neighboring gene microRNA mir-3251 Neighboring gene DExD-box helicase 52

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Silencing Br-C impairs larval development and chitin synthesis in Lymantria dispar larvae. Ding N, et al. J Insect Physiol, 2020 Apr. PMID 32126216
    2. Construction and characterization of bacterial artificial chromosome libraries from the silkworm, Bombyx mori. Wu C, et al. Mol Gen Genet, 1999 Jun. PMID 10394907
    3. Use of Sindbis virus-mediated RNA interference to demonstrate a conserved role of Broad-Complex in insect metamorphosis. Uhlirova M, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14668449, Free PMC Article
    4. cDNA cloning, gene structure, and expression of Broad-Complex (BR-C) genes in the silkworm, Bombyx mori. Ijiro T, et al. Insect Biochem Mol Biol, 2004 Sep. PMID 15350615
    5. Structure and expression of the gene encoding a Broad-Complex homolog in the silkworm, Bombyx mori. Nishita Y, et al. Gene, 2004 Sep 15. PMID 15363856

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-wide identification of target genes for transcription factor BR-C in the silkworm, Bombyx mori.
      Title: Genome-wide identification of target genes for transcription factor BR-C in the silkworm, Bombyx mori.
    2. Silencing Br-C impairs larval development and chitin synthesis in Lymantria dispar larvae.
      Title: Silencing Br-C impairs larval development and chitin synthesis in Lymantria dispar larvae.
    3. Broad-Complex Z4 (BR-C Z4) was up-regulated by 20-hydroxyecdysone just before pupation, while transcription factor FoxJ and CHSA-2b were up-regulated during the pupal stage.
      Title: BR-C Z4 and FoxJ interact to regulate expression of a chitin synthase gene CHSA-2b in the pupal wing discs of the silkworm, Bombyx mori.
    4. findings indicate that PKA-mediated phosphorylation inhibits silkworm BR-C activity by interfering with its binding to DNA and that 20E signaling relieves PKA-mediated phosphorylation of BR-C, thereby maintaining its transcriptional activity
      Title: Protein kinase A-mediated phosphorylation of the Broad-Complex transcription factor in silkworm suppresses its transcriptional activity.
    5. transcription factor BR-C Z4 enhances the expression of chitinase 5 during metamorphosis
      Title: 20-hydroxyecdysone enhances the expression of the chitinase 5 via Broad-Complex Zinc-Finger 4 during metamorphosis in silkworm, Bombyx mori.
    6. longitudinals lacking (lola), tramtrack (ttk), broad complex (br), and fruitless (fru) are BTB-C2H2 zinc finger proteins conserved in different insects
      Title: The Fruitless gene in Nasonia displays complex sex-specific splicing and contains new zinc finger domains.
    7. In larvae, uvenile hormone induced the expression of Kr-h1 and concurrently suppressed 20-hydroxyecdysone-induced expression of BR-C.
      Title: Krüppel Homolog 1 Inhibits Insect Metamorphosis via Direct Transcriptional Repression of Broad-Complex, a Pupal Specifier Gene.
    8. The PKC-mediated phosphorylation and nuclear import of BR-C is determined by its interaction with RACK1.
      Title: Nuclear import of transcription factor BR-C is mediated by its interaction with RACK1.
    9. BR-C Z2 regulated the transcription of BMWCP10.
      Title: Activation of BMWCP10 promoter and regulation by BR-C Z2 in wing disc of Bombyx mori.
    10. BMWCP5 transcription is primarily regulated by FTZ-F1, and the stage-specific enhancement is brought about through BR-Z4.
      Title: betaFTZ-F1 and Broad-Complex positively regulate the transcription of the wing cuticle protein gene, BMWCP5, in wing discs of Bombyx mori.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    broad-complex core protein; broad-complex
    Names
    broad

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001043511.1 → NP_001036976.1  broad-complex core protein isoform Z4

      See identical proteins and their annotated locations for NP_001036976.1

      Status: PROVISIONAL

      Source sequence(s)
      AB181191
      UniProtKB/TrEMBL
      Q6I6N4, Q6I7P3
      Conserved Domains (2) summary
      sd00017
      Location:364 → 390
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24 → 119
      BTB; BTB/POZ domain

    2. NM_001111333.1 → NP_001104803.1  broad-complex core protein isoform Z2

      See identical proteins and their annotated locations for NP_001104803.1

      Status: PROVISIONAL

      Source sequence(s)
      AB113087
      UniProtKB/TrEMBL
      Q65YS5, Q6I7P4
      Conserved Domains (2) summary
      sd00017
      Location:361 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18315
      Location:33 → 116
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    3. NM_001111334.1 → NP_001104804.1  broad-complex core protein isoform Z1

      See identical proteins and their annotated locations for NP_001104804.1

      Status: PROVISIONAL

      Source sequence(s)
      AB181189
      UniProtKB/TrEMBL
      Q65YS5, Q6I7P6
      Conserved Domains (2) summary
      sd00020
      Location:366 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18315
      Location:33 → 116
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    RefSeqs of Annotated Genomes: GCF_030269925.1-RS_2024_01

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM3026992v2 Primary Assembly

    Genomic

    1. NC_085114.1 Reference ASM3026992v2 Primary Assembly

      Range
      15276515..15459293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021346252.3 → XP_021201927.1  broad-complex isoform X1

      UniProtKB/TrEMBL
      A0A8R2QZD6
      Conserved Domains (3) summary
      sd00017
      Location:375 → 396
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18315
      Location:33 → 116
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins
      pfam17772
      Location:385 → 423
      zf-MYST; MYST family zinc finger domain

    2. XM_021346254.3 → XP_021201929.1  broad-complex isoform X1

      UniProtKB/TrEMBL
      A0A8R2QZD6
      Conserved Domains (3) summary
      sd00017
      Location:375 → 396
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18315
      Location:33 → 116
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins
      pfam17772
      Location:385 → 423
      zf-MYST; MYST family zinc finger domain

    3. XM_062669542.1 → XP_062525526.1  broad-complex isoform X2

      UniProtKB/TrEMBL
      Q6I6N4

    4. XM_021346253.3 → XP_021201928.1  broad-complex isoform X1

      UniProtKB/TrEMBL
      A0A8R2QZD6
      Conserved Domains (3) summary
      sd00017
      Location:375 → 396
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18315
      Location:33 → 116
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins
      pfam17772
      Location:385 → 423
      zf-MYST; MYST family zinc finger domain

    5. XM_021346258.3 → XP_021201933.1  broad-complex isoform X3

      UniProtKB/TrEMBL
      Q65YS5, Q6I7P6
      Conserved Domains (2) summary
      sd00020
      Location:366 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18315
      Location:33 → 116
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    6. XM_021346257.3 → XP_021201932.1  broad-complex isoform X2

      UniProtKB/TrEMBL
      Q6I6N4, Q6I7P3
      Conserved Domains (2) summary
      sd00017
      Location:364 → 390
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24 → 119
      BTB; BTB/POZ domain

    7. XM_021346256.3 → XP_021201931.1  broad-complex isoform X1

      UniProtKB/TrEMBL
      A0A8R2QZD6
      Conserved Domains (3) summary
      sd00017
      Location:375 → 396
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18315
      Location:33 → 116
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins
      pfam17772
      Location:385 → 423
      zf-MYST; MYST family zinc finger domain

    8. XM_038012249.2 → XP_037868177.1  broad-complex isoform X1

      UniProtKB/TrEMBL
      A0A8R2QZD6
      Conserved Domains (3) summary
      sd00017
      Location:375 → 396
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18315
      Location:33 → 116
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins
      pfam17772
      Location:385 → 423
      zf-MYST; MYST family zinc finger domain

    9. XM_062669541.1 → XP_062525525.1  broad-complex isoform X2

      UniProtKB/TrEMBL
      Q6I6N4

    10. XM_038012250.2 → XP_037868178.1  broad-complex isoform X1

      UniProtKB/TrEMBL
      A0A8R2QZD6
      Conserved Domains (3) summary
      sd00017
      Location:375 → 396
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18315
      Location:33 → 116
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins
      pfam17772
      Location:385 → 423
      zf-MYST; MYST family zinc finger domain

    11. XM_062669543.1 → XP_062525527.1  broad-complex isoform X3

      UniProtKB/TrEMBL
      Q6I7P6
    Nucleotide Protein
    Heading Accession and Version

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