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    LHX3 LIM homeobox 3 [ Gallus gallus (chicken) ]

    Gene ID: 373940, updated on 17-Aug-2024

    Summary

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    Symbol
    LHX3provided by CGNC
    Full Name
    LIM homeobox 3provided by CGNC
    Primary source
    CGNC:48967
    See related
    Ensembl:ENSGALG00010028203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    LIM3; lim-3
    Orthologs
    human mouse all
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    Genomic context

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    See LHX3 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 17 NC_052548.1 (8652049..8658840)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 17 NC_052589.1 (8062544..8069323)

    Chromosome 17 - NC_052548.1Genomic Context describing neighboring genes Neighboring gene centrosome-associated protein 350-like Neighboring gene quiescin sulfhydryl oxidase 2 Neighboring gene uncharacterized LOC121107033 Neighboring gene chromosome 9 open reading frame 69 Neighboring gene NACC family member 2 Neighboring gene uncharacterized LOC107052223

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Zinc finger gene nolz1 regulates the formation of retinal progenitor cells and suppresses the Lim3/Lhx3 phenotype of retinal bipolar cells in chicken retina. Blixt MKE, et al. Dev Dyn, 2018 Apr. PMID 29139167
    2. LIM homeodomain proteins Islet-1 and Lim-3 expressions in the developing pineal gland of chick embryo by immunohistochemistry. Zhang JH, et al. J Pineal Res, 2006 Oct. PMID 16948785
    3. Detailed analysis of the δ-crystallin mRNA-expressing region in early development of the chick pituitary gland. Inoue M, et al. J Mol Histol, 2012 Jun. PMID 22461196
    4. Expression patterns of Shh, Ptc2, Raldh3, Pitx2, Isl1, Lim3 and Pax6 in the developing chick hypophyseal placode and Rathke's pouch. Sjödal M, et al. Gene Expr Patterns, 2008 Sep. PMID 18647663
    5. Semaphorin and neuropilin co-expression in motoneurons sets axon sensitivity to environmental semaphorin sources during motor axon pathfinding. Moret F, et al. Development, 2007 Dec. PMID 18039974

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sustained overexpression of Nolz1 in the retina gave fewer Lim3/Lhx3 bipolar cells.
      Title: Zinc finger gene nolz1 regulates the formation of retinal progenitor cells and suppresses the Lim3/Lhx3 phenotype of retinal bipolar cells in chicken retina.
    2. Embryonic chick pituitary gland consists of two different regions where delta-crystallin and Lhx3 are expressed.
      Title: Detailed analysis of the δ-crystallin mRNA-expressing region in early development of the chick pituitary gland.
    3. Lim3 and Pax6 are expressed from stage 10 in the prospective hypophyseal placode
      Title: Expression patterns of Shh, Ptc2, Raldh3, Pitx2, Isl1, Lim3 and Pax6 in the developing chick hypophyseal placode and Rathke's pouch.
    4. May be involved in regulating the development and functional maturation of the pineal gland.
      Title: LIM homeodomain proteins Islet-1 and Lim-3 expressions in the developing pineal gland of chick embryo by immunohistochemistry.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LIM/homeobox protein Lhx3
    Names
    LIM homeobox protein 3
    homeobox protein LIM-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030335.2 → NP_001025506.1  LIM/homeobox protein Lhx3

      See identical proteins and their annotated locations for NP_001025506.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000308
      UniProtKB/Swiss-Prot
      P53412
      Related
      ENSGALP00010042094.1, ENSGALT00010068351.1
      Conserved Domains (3) summary
      cd09376
      Location:87 → 142
      LIM2_Lhx3_Lhx4; The second LIM domain of Lhx3-Lhx4 family
      cd09467
      Location:25 → 79
      LIM1_Lhx3b; The first LIM domain of Lhx3b
      pfam00046
      Location:157 → 210
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      8652049..8658840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025156012.3 → XP_025011780.1  LIM/homeobox protein Lhx3 isoform X1

      Conserved Domains (3) summary
      cd09376
      Location:87 → 142
      LIM2_Lhx3_Lhx4; The second LIM domain of Lhx3-Lhx4 family
      cd09467
      Location:25 → 79
      LIM1_Lhx3b; The first LIM domain of Lhx3b
      pfam00046
      Location:208 → 261
      Homeobox; Homeobox domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      8062544..8069323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046928637.1 → XP_046784593.1  LIM/homeobox protein Lhx3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53412.1 GenPept UniProtKB/Swiss-Prot:P53412

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials