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    Dhx15 DEAH-box helicase 15 [ Mus musculus (house mouse) ]

    Gene ID: 13204, updated on 5-Nov-2024

    Summary

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    Official Symbol
    Dhx15provided by MGI
    Official Full Name
    DEAH-box helicase 15provided by MGI
    Primary source
    MGI:MGI:1099786
    See related
    Ensembl:ENSMUSG00000029169 AllianceGenome:MGI:1099786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DBP1; HRH2; DEAH9; Ddx15; mDEAH9
    Summary
    Predicted to enable RNA helicase activity and double-stranded RNA binding activity. Involved in antiviral innate immune response and defense response to bacterium. Predicted to be located in nuclear speck. Predicted to be part of U12-type spliceosomal complex and U2-type post-mRNA release spliceosomal complex. Is expressed in several structures, including aorta; forelimb bud; future brain; liver; and spleen. Orthologous to human DHX15 (DEAH-box helicase 15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 55.8), CNS E14 (RPKM 38.2) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhx15 in Genome Data Viewer
    Location:
    5 C1; 5 27.51 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (52307545..52347888, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (52150203..52190546, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Neighboring gene predicted gene 42614 Neighboring gene STARR-seq mESC enhancer starr_13050 Neighboring gene STARR-seq mESC enhancer starr_13051 Neighboring gene STARR-seq mESC enhancer starr_13052 Neighboring gene STARR-seq mESC enhancer starr_13053 Neighboring gene STARR-seq mESC enhancer starr_13054 Neighboring gene STARR-seq mESC enhancer starr_13055 Neighboring gene RIKEN cDNA 9230114K14 gene Neighboring gene predicted gene, 40302 Neighboring gene microRNA 6417 Neighboring gene STARR-seq mESC enhancer starr_13057 Neighboring gene RIKEN cDNA C130083M11 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions. Wang G, et al. Cell Mol Immunol, 2022 Jun. PMID 35322175, Free PMC Article
    2. Ceria nanoparticles enhance endochondral ossification-based critical-sized bone defect regeneration by promoting the hypertrophic differentiation of BMSCs via DHX15 activation. Li J, et al. FASEB J, 2019 May. PMID 30776318
    3. Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15. Zhu H, et al. Nat Commun, 2024 Feb 24. PMID 38402201, Free PMC Article
    4. Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice. Portolés I, et al. Int J Mol Sci, 2024 Mar 27. PMID 38612527, Free PMC Article
    5. TFIP11 interacts with mDEAH9, an RNA helicase involved in spliceosome disassembly. Wen X, et al. Int J Mol Sci, 2008 Nov. PMID 19165350, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice.
      Title: Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice.
    2. Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15.
      Title: Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15.
    3. The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions.
      Title: The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions.
    4. DHX15 is required to control RNA virus-induced intestinal inflammation.
      Title: DHX15 is required to control RNA virus-induced intestinal inflammation.
    5. The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice.
      Title: The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice.
    6. The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells.
      Title: The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells.
    7. ceria nanoparticles significantly promoted endochondral ossification-based bone regeneration by ensuring sufficient hypertrophic differentiation via the activation of the RNA helicase, DEAH (Asp-Glu-Ala-His) box helicase 15, and its downstream target, p38 MAPK.
      Title: Ceria nanoparticles enhance endochondral ossification-based critical-sized bone defect regeneration by promoting the hypertrophic differentiation of BMSCs via DHX15 activation.
    8. These data demonstrate that Nlrp6 functions with Dhx15 as a viral RNA sensor to induce IFN-stimulated genes, and this effect is especially important in the intestinal tract.
      Title: Nlrp6 regulates intestinal antiviral innate immunity.
    9. DHX15, a DEXDc helicase family member, plays an important role in sensing RNA and RNA viruses in bone marrow dendritic cells.
      Title: DHX15 senses double-stranded RNA in myeloid dendritic cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117685

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables double-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antiviral innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antiviral innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to alkaloid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U12-type spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2-type post-mRNA release spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U2-type post-mRNA release spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DHX15
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15 (RNA helicase A)
    DEAH (Asp-Glu-Ala-His) box polypeptide 15
    DEAH box protein 15
    pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    NP_001036085.1
    NP_031865.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042620.2 → NP_001036085.1  ATP-dependent RNA helicase DHX15 isoform 1

      See identical proteins and their annotated locations for NP_001036085.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains an alternate 3' terminal exon, resulting in a different 3' UTR and 3' coding region, compared to variant 2. It encodes isoform 1, which has a shorter and distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AK043111, AK149869, BY285872
      Consensus CDS
      CCDS80280.1
      UniProtKB/TrEMBL
      Q3UDX4, Q497W9
      Related
      ENSMUSP00000143069.2, ENSMUST00000199321.5
      Conserved Domains (5) summary
      smart00490
      Location:382 → 475
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:149 → 322
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:545 → 628
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:154 → 295
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:662 → 701
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    2. NM_007839.3 → NP_031865.2  ATP-dependent RNA helicase DHX15 isoform 2

      See identical proteins and their annotated locations for NP_031865.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AK145983, AK149869, BP767627, BY285872
      Consensus CDS
      CCDS39085.1
      UniProtKB/Swiss-Prot
      O35286, Q99L91
      UniProtKB/TrEMBL
      Q3TFE5, Q3UKJ6
      Related
      ENSMUSP00000031061.8, ENSMUST00000031061.12
      Conserved Domains (1) summary
      COG1643
      Location:124 → 763
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RNA

    1. NR_104311.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site resulting in a shorter transcript, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK145983, AK168835, AK169174, BP767627, BY285872

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      52307545..52347888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35286.2 GenPept UniProtKB/Swiss-Prot:O35286

    Gene LinkOut

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