Mknk1 MAP kinase-interacting serine/threonine kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mknk1provided by MGI
Official Full Name: MAP kinase-interacting serine/threonine kinase 1provided by MGI
Primary source: MGI:MGI:894316
See related: Ensembl:ENSMUSG00000028708 AllianceGenome:MGI:894316
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mnk1; 2410048M24Rik
Summary: This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiation factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Expression: Ubiquitous expression in thymus adult (RPKM 21.1), lung adult (RPKM 18.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 53.06 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (115695140..115736453)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (115837943..115879256)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-370-3p Regulates Adipogenesis through Targeting Mknk1.
Title: miR-370-3p Regulates Adipogenesis through Targeting Mknk1.
Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity.
Title: Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity.
phosphorylation pattern of eIF4E responds faithfully to Rapamycin inhibition, the prolonged exposure to Rapamycin rescues the loss of eIF4E phosphorylation through Mnk1 activation.
Title: Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1.
MNK1 participates in mediating high-fat diet-induced insulin resistance. Our findings reveal distinct roles for the MNKs in a novel area of disease biology
Title: MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways.
data suggest a physiological role for MNK1a-Ser(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo.
Title: AMP-activated Protein Kinase Up-regulates Mitogen-activated Protein (MAP) Kinase-interacting Serine/Threonine Kinase 1a-dependent Phosphorylation of Eukaryotic Translation Initiation Factor 4E.
Mnk1 is a novel pancreatic acinar cell-specific stress response kinase that regulates digestive enzyme abundance and eIF4E phosphorylation.
Title: Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice.
Long-term potentiation (LTP) consolidation in the dentate gyrus of live rodents requires sustained (hours) BDNF-TrkB signaling and from TrkB to MAP-kinase-interacting kinase.
Title: Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK.
Data suggest that Mnk1 and Mnk2 regulate cell migration/wound healing, expression of vimentin, stability of vimentin protein, and binding of eIF4E (eukaryotic translation initiation factor 4E) and Cyfip1 (cytoplasmic FMR1 interacting protein 1).
Title: The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding.
Mnk1/2 has a minimal role in T cell development and activation but may regulate non-T cell lineages to control Th1 and Th17 differentiation in vivo.
Title: Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.
oncogenic role for Mnk1/2 in tumor development
Title: Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mknk1 (e-PCR), detects polymorphism
- UniSTS:507069

NoName (e-PCR)
- UniSTS:235001

Y11091 (e-PCR)
- UniSTS:185596

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in response to salt stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: MAP kinase-interacting serine/threonine-protein kinase 1

Names: MAPK signal-integrating kinase 1

NP_001272416.1

EC 2.7.11.1

NP_001272417.1

EC 2.7.11.1

NP_001342103.1

EC 2.7.11.1

NP_001356167.1

EC 2.7.11.1

NP_067436.1

EC 2.7.11.1

XP_006502885.1

EC 2.7.11.1

XP_006502888.1

EC 2.7.11.1

XP_030109148.1

EC 2.7.11.1

XP_036019677.1

EC 2.7.11.1

XP_036019678.1

EC 2.7.11.1

XP_036019679.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285487.1 → NP_001272416.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform a

See identical proteins and their annotated locations for NP_001272416.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AK141298, AL627085, BB841753, BQ551007, BY209061, CN538557, CO425179

UniProtKB/TrEMBL

Q3TDV2, Q3U1I8

Related

ENSMUST00000144235.8

Conserved Domains (1) summary

cd14174
Location:40 → 328

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
NM_001285488.1 → NP_001272417.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform b

See identical proteins and their annotated locations for NP_001272417.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.

Source sequence(s)

AK141298, AL627085, BQ551007, BY209061, CN538557, CO425179

Consensus CDS

CCDS18498.1

UniProtKB/TrEMBL

A2A8W8, Q3TDV2

Related

ENSMUSP00000102123.4, ENSMUST00000106513.10

Conserved Domains (2) summary

smart00220
Location:41 → 321

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14174
Location:34 → 322

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
NM_001355174.1 → NP_001342103.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform c

Status: REVIEWED

Source sequence(s)

AK141298, BP762163, BQ551007, BY209061, CN538557, CO425179

Conserved Domains (1) summary

cd14174
Location:34 → 322

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
NM_001369238.1 → NP_001356167.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform d

Status: REVIEWED

Source sequence(s)

AL627085

UniProtKB/TrEMBL

Q3TDV2

Conserved Domains (1) summary

cl21453
Location:34 → 290

PKc_like; Protein Kinases, catalytic domain
NM_021461.5 → NP_067436.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform b

See identical proteins and their annotated locations for NP_067436.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.

Source sequence(s)

AK141298, BQ551007, BY209061, CN538557, CO425179

Consensus CDS

CCDS18498.1

UniProtKB/TrEMBL

A2A8W8, Q3TDV2

Related

ENSMUSP00000019677.6, ENSMUST00000019677.12

Conserved Domains (2) summary

smart00220
Location:41 → 321

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14174
Location:34 → 322

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

115695140..115736453

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163785.1 → XP_036019678.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

Conserved Domains (1) summary

cd14174
Location:34 → 322

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
XM_006502822.4 → XP_006502885.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

See identical proteins and their annotated locations for XP_006502885.1

UniProtKB/TrEMBL

Q3TDV2, Q3U1I8

Conserved Domains (1) summary

cd14174
Location:40 → 328

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
XM_006502825.4 → XP_006502888.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

Conserved Domains (1) summary

cd14174
Location:40 → 328

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
XM_036163784.1 → XP_036019677.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

UniProtKB/TrEMBL

Q3TDV2

Conserved Domains (1) summary

cd14174
Location:38 → 326

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
XM_036163786.1 → XP_036019679.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X6

Conserved Domains (1) summary

cl21453
Location:31 → 235

PKc_like; Protein Kinases, catalytic domain
XM_030253288.2 → XP_030109148.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

Conserved Domains (1) summary

cd14174
Location:38 → 326

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1