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    FCRLB Fc receptor like B [ Homo sapiens (human) ]

    Gene ID: 127943, updated on 14-Nov-2024

    Summary

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    Official Symbol
    FCRLBprovided by HGNC
    Official Full Name
    Fc receptor like Bprovided by HGNC
    Primary source
    HGNC:HGNC:26431
    See related
    Ensembl:ENSG00000162746 MIM:609251; AllianceGenome:HGNC:26431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FcRY; FCRL2; FCRLY; FREB2; FCRLM2; FREB-2
    Summary
    FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in kidney (RPKM 1.2), appendix (RPKM 0.8) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FCRLB in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161721544..161728143)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (161065867..161072464)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161691334..161697933)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1995 Neighboring gene Fc receptor like A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2000 Neighboring gene RNA, 7SL, cytoplasmic 466, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2005 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161719946-161720592 Neighboring gene dual specificity phosphatase 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the human FCRL2 gene. Chikaev NA, et al. Genomics, 2005 Feb. PMID 15676285
    2. FCGR2B and FCRLB gene polymorphisms associated with IgA nephropathy. Zhou XJ, et al. PLoS One, 2013. PMID 23593433, Free PMC Article
    3. FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. Masuda K, et al. Gene, 2005 Dec 19. PMID 16263223
    4. A new Fc receptor homolog, FREB2, found in germinal center B cells. Wilson TJ, et al. Genes Immun, 2005 Jun. PMID 15815692
    5. The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL. Taylor AI, et al. Immunogenetics, 2007 Apr. PMID 17273841

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The aim of the study was to associate multiple polymorphisms within FCGR gene locus with IgA nephropathy in a large Chinese cohort.
      Title: FCGR2B and FCRLB gene polymorphisms associated with IgA nephropathy.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene variants associated with ischemic stroke: the cardiovascular health study.
    3. Fcry is upregulated by short-term treatment with BAFF/BLyS, which promotes B cell survival rather than proliferation
      Title: FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation.
    4. Expression analysis revealed FCRL2 mRNA only in placenta.FCRL2 is differentially expressed by transformed B cell lines.
      Title: Cloning and characterization of the human FCRL2 gene.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31052, RP11-474I16.6

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immunoglobulin mediated immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fc receptor-like B
    Names
    fc receptor homolog expressed in B cells protein 2
    fc receptor-like and mucin-like protein 2
    fc receptor-like protein 2
    fc receptor-related protein Y

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002901.4 → NP_001002901.1  Fc receptor-like B isoform 1 precursor

      See identical proteins and their annotated locations for NP_001002901.1

      Status: VALIDATED

      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS30927.1
      UniProtKB/Swiss-Prot
      A2A3J5, A2A3J7, Q5VXA6, Q6BAA0, Q6BAA1, Q6BAA2, Q6BAA3, Q6BAA4, Q8IXZ7
      Related
      ENSP00000356925.2, ENST00000367948.7
      Conserved Domains (3) summary
      cd05752
      Location:23 → 100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:104 → 186
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:114 → 190
      IG_like; Immunoglobulin like

    2. NM_001288829.1 → NP_001275758.1  Fc receptor-like B isoform 2 precursor

      See identical proteins and their annotated locations for NP_001275758.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as hFCRL2c1) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AY670684, BQ014014, DQ021957
      Consensus CDS
      CCDS72963.1
      UniProtKB/Swiss-Prot
      Q6BAA4
      Related
      ENSP00000356923.3, ENST00000367946.7
      Conserved Domains (3) summary
      cd05752
      Location:23 → 100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:104 → 186
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:114 → 190
      IG_like; Immunoglobulin like

    3. NM_001288830.1 → NP_001275759.1  Fc receptor-like B isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, also known as hFCRL2c2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AY670685, BQ014014, BX364259, DQ021957
      Consensus CDS
      CCDS72965.1
      UniProtKB/Swiss-Prot
      Q6BAA4
      Related
      ENSP00000356922.1, ENST00000367945.5
      Conserved Domains (3) summary
      cd05752
      Location:16 → 93
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:97 → 179
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:107 → 183
      IG_like; Immunoglobulin like

    4. NM_001288831.1 → NP_001275760.1  Fc receptor-like B isoform 4 precursor

      See identical proteins and their annotated locations for NP_001275760.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4, also known as hFCRL2b1) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AY670686, BQ014014, DQ021957
      Consensus CDS
      CCDS72962.1
      UniProtKB/Swiss-Prot
      Q6BAA4
      Related
      ENSP00000338598.5, ENST00000336830.9
      Conserved Domains (3) summary
      cd05752
      Location:23 → 100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:104 → 186
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:114 → 190
      IG_like; Immunoglobulin like

    5. NM_001288832.1 → NP_001275761.1  Fc receptor-like B isoform 5 precursor

      See identical proteins and their annotated locations for NP_001275761.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5, also known as hFCRL2b2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 5, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AY670687, BQ014014, BX364259, DQ021957
      Consensus CDS
      CCDS72964.1
      UniProtKB/Swiss-Prot
      Q6BAA4
      Related
      ENSP00000356921.3, ENST00000367944.3
      Conserved Domains (3) summary
      cd05752
      Location:16 → 93
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:97 → 179
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:107 → 183
      IG_like; Immunoglobulin like

    6. NM_001320241.1 → NP_001307170.1  Fc receptor-like B isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 6 encode the same isoform (1).
      Source sequence(s)
      AK290733, AY670683, BQ014014
      Consensus CDS
      CCDS30927.1
      UniProtKB/Swiss-Prot
      A2A3J5, A2A3J7, Q5VXA6, Q6BAA0, Q6BAA1, Q6BAA2, Q6BAA3, Q6BAA4, Q8IXZ7
      Conserved Domains (3) summary
      cd05752
      Location:23 → 100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:104 → 186
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:114 → 190
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      161721544..161728143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      161065867..161072464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152378.1: Suppressed sequence

      Description
      NM_152378.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6BAA4.1 GenPept UniProtKB/Swiss-Prot:Q6BAA4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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