Naip7 NLR family, apoptosis inhibitory protein 7 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Naip7provided by MGI
Official Full Name: NLR family, apoptosis inhibitory protein 7provided by MGI
Primary source: MGI:MGI:1858256
See related: AllianceGenome:MGI:1858256
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Birc1g; Naip-rs4B
Summary: This gene is found in 129X1 mice, but not in C57BL/6J mice, so it is not present in GRCm38.p4 (see PMID:12483212). [provided by RefSeq, Mar 2019]
Annotation information: not in current annotation release
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Genomic context

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Location:: 13 D1; 13

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

Naip1 (e-PCR), detects polymorphism
- UniSTS:534557

D13Die34 (e-PCR), detects polymorphism
- UniSTS:164905

Birc1d (e-PCR), detects polymorphism
- UniSTS:256361

D13Die31a (e-PCR), detects polymorphism
- UniSTS:186736

Naip1 (e-PCR), detects polymorphism
- UniSTS:496020

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_negative_effect regulation of apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of IPAF inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 1g

Names: neuronal apoptosis inhibitory protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021545.1 → NP_067520.1 baculoviral IAP repeat-containing protein 1g

See identical proteins and their annotated locations for NP_067520.1

Status: PROVISIONAL

Source sequence(s)

AH009619

UniProtKB/Swiss-Prot

Q9JIB3

UniProtKB/TrEMBL

Q8CH64

Conserved Domains (6) summary

cd09293
Location:1072 → 1271

AMN1; Antagonist of mitotic exit network protein 1

smart00238
Location:159 → 229

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:279 → 346

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

sd00033
Location:1055 → 1078

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1132 → 1156

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:464 → 618

NACHT; NACHT domain