Rhbdd3 rhomboid domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhbdd3provided by MGI
Official Full Name: rhomboid domain containing 3provided by MGI
Primary source: MGI:MGI:2444684
See related: Ensembl:ENSMUSG00000034175 AllianceGenome:MGI:2444684
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ptag
Summary: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within several processes, including MAPK cascade; negative regulation of natural killer cell activation; and positive regulation of protein catabolic process. Predicted to be located in membrane. Orthologous to human RHBDD3 (rhomboid domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 54.0), genital fat pad adult (RPKM 23.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 3.26 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (5048282..5056100)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (5098282..5106100)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

report that Rhbdd3, a member of the rhomboid family of proteases, suppressed the activation of dendritic cells and production of interleukin 6 (IL-6) triggered by Toll-like receptors
Title: Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO.
Rhbdd3 is a feedback inhibitor of TLR3-triggered NK cell activation
Title: Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of natural killer cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of acute inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rhomboid domain-containing protein 3

Names: pituitary-derived proapoptotic

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290491.1 → NP_001277420.1 rhomboid domain-containing protein 3 isoform b

See identical proteins and their annotated locations for NP_001277420.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses two alternate splice sites in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.

Source sequence(s)

AK053223, AL645845, BB841991, BY641428

Consensus CDS

CCDS70133.1

UniProtKB/Swiss-Prot

Q8BP97

Related

ENSMUSP00000044703.6, ENSMUST00000036320.12

Conserved Domains (1) summary

cl21463
Location:316 → 359

UBA_like_SF; UBA domain-like superfamily
NM_001290492.1 → NP_001277421.1 rhomboid domain-containing protein 3 isoform a

See identical proteins and their annotated locations for NP_001277421.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 encode the same isoform.

Source sequence(s)

AK077457, AL645845, BB841991, BC145287, BY641428

Consensus CDS

CCDS24397.1

UniProtKB/Swiss-Prot

A2RTD2, B7ZNK0, Q3U0Y4, Q5SUT5, Q5SUT6, Q5SUT7, Q8BP97

UniProtKB/TrEMBL

B7ZNJ8

Conserved Domains (1) summary

cl21463
Location:326 → 369

UBA_like_SF; UBA domain-like superfamily
NM_001290493.1 → NP_001277422.1 rhomboid domain-containing protein 3 isoform a

See identical proteins and their annotated locations for NP_001277422.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).

Source sequence(s)

AK077457, AL645845, BY641428

Consensus CDS

CCDS24397.1

UniProtKB/Swiss-Prot

A2RTD2, B7ZNK0, Q3U0Y4, Q5SUT5, Q5SUT6, Q5SUT7, Q8BP97

UniProtKB/TrEMBL

B7ZNJ8

Related

ENSMUSP00000105504.3, ENSMUST00000109878.9

Conserved Domains (1) summary

cl21463
Location:326 → 369

UBA_like_SF; UBA domain-like superfamily
NM_177370.4 → NP_796344.1 rhomboid domain-containing protein 3 isoform a

See identical proteins and their annotated locations for NP_796344.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).

Source sequence(s)

AK077457, AL645845, BB841991, BY641428

Consensus CDS

CCDS24397.1

UniProtKB/Swiss-Prot

A2RTD2, B7ZNK0, Q3U0Y4, Q5SUT5, Q5SUT6, Q5SUT7, Q8BP97

UniProtKB/TrEMBL

B7ZNJ8

Related

ENSMUSP00000099131.4, ENSMUST00000101610.10

Conserved Domains (1) summary

cl21463
Location:326 → 369

UBA_like_SF; UBA domain-like superfamily

RNA

NR_110961.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks a 5' exon, and uses two alternate splice sites at internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK053223, AK077457, BY641428

Related

ENSMUST00000129016.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

5048282..5056100

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514714.4 → XP_006514777.1 rhomboid domain-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_006514777.1

UniProtKB/Swiss-Prot

A2RTD2, B7ZNK0, Q3U0Y4, Q5SUT5, Q5SUT6, Q5SUT7, Q8BP97

UniProtKB/TrEMBL

B7ZNJ8

Conserved Domains (1) summary

cl21463
Location:326 → 369

UBA_like_SF; UBA domain-like superfamily
XM_006514715.3 → XP_006514778.1 rhomboid domain-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_006514778.1

UniProtKB/Swiss-Prot

A2RTD2, B7ZNK0, Q3U0Y4, Q5SUT5, Q5SUT6, Q5SUT7, Q8BP97

UniProtKB/TrEMBL

B7ZNJ8

Conserved Domains (1) summary

cl21463
Location:326 → 369

UBA_like_SF; UBA domain-like superfamily
XM_030246061.1 → XP_030101921.1 rhomboid domain-containing protein 3 isoform X3
XM_017314584.2 → XP_017170073.1 rhomboid domain-containing protein 3 isoform X2

UniProtKB/Swiss-Prot

Q8BP97

Conserved Domains (1) summary

cl21463
Location:316 → 359

UBA_like_SF; UBA domain-like superfamily
XM_030246060.1 → XP_030101920.1 rhomboid domain-containing protein 3 isoform X1

UniProtKB/Swiss-Prot

A2RTD2, B7ZNK0, Q3U0Y4, Q5SUT5, Q5SUT6, Q5SUT7, Q8BP97

UniProtKB/TrEMBL

B7ZNJ8

Conserved Domains (1) summary

cl21463
Location:326 → 369

UBA_like_SF; UBA domain-like superfamily
XM_036156745.1 → XP_036012638.1 rhomboid domain-containing protein 3 isoform X1

UniProtKB/Swiss-Prot

A2RTD2, B7ZNK0, Q3U0Y4, Q5SUT5, Q5SUT6, Q5SUT7, Q8BP97

UniProtKB/TrEMBL

B7ZNJ8

Conserved Domains (1) summary

cl21463
Location:326 → 369

UBA_like_SF; UBA domain-like superfamily
XM_036156746.1 → XP_036012639.1 rhomboid domain-containing protein 3 isoform X1

UniProtKB/Swiss-Prot

A2RTD2, B7ZNK0, Q3U0Y4, Q5SUT5, Q5SUT6, Q5SUT7, Q8BP97

UniProtKB/TrEMBL

B7ZNJ8

Conserved Domains (1) summary

cl21463
Location:326 → 369

UBA_like_SF; UBA domain-like superfamily