U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    OAZ3 ornithine decarboxylase antizyme 3 [ Alligator mississippiensis (American alligator) ]

    Gene ID: 102560344, updated on 12-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    OAZ3
    Gene description
    ornithine decarboxylase antizyme 3
    Locus tag
    Y1Q_0012353
    See related
    EnsemblRapid:ENSAMIG00015001088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Alligator mississippiensis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; Alligator
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. [provided by RefSeq, Aug 2014]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See OAZ3 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_09 current rAllMis1 (GCF_030867095.1) 15 NC_081838.1 (19565881..19569827, complement)
    102 previous assembly ASM28112v4 (GCF_000281125.3) Unplaced Scaffold NW_017713996.1 (786392..790343)

    Chromosome 15 - NC_081838.1Genomic Context describing neighboring genes Neighboring gene semaphorin-7A Neighboring gene uncharacterized LOC132245526 Neighboring gene tudor and KH domain containing Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene regulatory subunit of type II PKA R-subunit domain containing 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Patterns of vertebrate isochore evolution revealed by comparison of expressed mammalian, avian, and crocodilian genes. Chojnowski JL, et al. J Mol Evol, 2007 Sep. PMID 17674077
    2. Polyamines in spermiogenesis: not now, darling. Coffino P. Proc Natl Acad Sci U S A, 2000 Apr 25. PMID 10781034, Free PMC Article
    3. Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation. Ivanov IP, et al. Nucleic Acids Res, 2007. PMID 17332016, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ornithine decarboxylase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ornithine decarboxylase antizyme 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290560.1 → NP_001277489.1  ornithine decarboxylase antizyme 3

      Status: REVIEWED

      Source sequence(s)
      ES316635, JAVFJH010000015
      Related
      ENSAMIP00015000979.1, ENSAMIT00015001708.1
      Conserved Domains (1) summary
      pfam02100
      Location:171 → 254
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: GCF_030867095.1-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference rAllMis1 Primary Assembly

    Genomic

    1. NC_081838.1 Reference rAllMis1 Primary Assembly

      Range
      19565881..19569827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.