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    Sparc secreted acidic cysteine rich glycoprotein [ Mus musculus (house mouse) ]

    Gene ID: 20692, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sparcprovided by MGI
    Official Full Name
    secreted acidic cysteine rich glycoproteinprovided by MGI
    Primary source
    MGI:MGI:98373
    See related
    Ensembl:ENSMUSG00000018593 AllianceGenome:MGI:98373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ON; BM-40
    Summary
    Enables calcium ion binding activity and extracellular matrix binding activity. Acts upstream of or within several processes, including bone development; cellular response to growth factor stimulus; and pigmentation. Located in extracellular matrix and extracellular space. Is expressed in several structures, including brain; egg cylinder; genitourinary system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 1043.9), bladder adult (RPKM 893.4) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sparc in Genome Data Viewer
    Location:
    11 B1.3; 11 33.04 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55284985..55310906, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55394159..55420080, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene FAT atypical cadherin 2 Neighboring gene STARR-seq mESC enhancer starr_29533 Neighboring gene predicted gene, 31842 Neighboring gene STARR-seq mESC enhancer starr_29535 Neighboring gene STARR-seq mESC enhancer starr_29537 Neighboring gene STARR-seq mESC enhancer starr_29542 Neighboring gene STARR-seq mESC enhancer starr_29544 Neighboring gene antioxidant 1 copper chaperone Neighboring gene predicted gene 12235

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reduced excision repair cross-complementing 1 expression associates with enhanced papilloma formation and fibroblast transformation after genetic disruption of secreted protein acidic and rich in cysteine. Kato Y, et al. Int J Oncol, 2005 Sep. PMID 16077926
    2. Lenses of SPARC-null mice exhibit an abnormal cell surface-basement membrane interface. Norose K, et al. Exp Eye Res, 2000 Sep. PMID 10973738
    3. Matricellular protein SPARC is translocated to the nuclei of immortalized murine lens epithelial cells. Yan Q, et al. J Cell Physiol, 2005 Apr. PMID 15534859
    4. Entorhinal deafferentation induces upregulation of SPARC in the mouse hippocampus. Liu X, et al. Brain Res Mol Brain Res, 2005 Nov 18. PMID 16137785
    5. SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery. Seet LF, et al. PLoS One, 2010 Feb 25. PMID 20195533, Free PMC Article

    See all (323) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet.
      Title: Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet.
    2. The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
      Title: The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
    3. Effect of Sparc knockout on the extracellular matrix of mouse periodontal ligament cells.
      Title: Effect of Sparc knockout on the extracellular matrix of mouse periodontal ligament cells.
    4. Hepatic SPARC Expression Is Associated with Inflammasome Activation during the Progression of Non-Alcoholic Fatty Liver Disease in Both Mice and Morbidly Obese Patients.
      Title: Hepatic SPARC Expression Is Associated with Inflammasome Activation during the Progression of Non-Alcoholic Fatty Liver Disease in Both Mice and Morbidly Obese Patients.
    5. Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity.
      Title: Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity.
    6. The Matricellular Protein SPARC Decreases in the Lacrimal Gland At Adulthood and During Inflammation.
      Title: The Matricellular Protein SPARC Decreases in the Lacrimal Gland At Adulthood and During Inflammation.
    7. Growth hormone/IGF-I-dependent signaling restores decreased expression of the myokine SPARC in aged skeletal muscle.
      Title: Growth hormone/IGF-I-dependent signaling restores decreased expression of the myokine SPARC in aged skeletal muscle.
    8. Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells.
      Title: Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells.
    9. SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension.
      Title: SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension.
    10. SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway.
      Title: SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (134)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (7)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lung development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in semicircular canal morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in platelet alpha granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in platelet alpha granule membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SPARC
    Names
    basement-membrane protein 40
    osteonectin
    secreted protein acidic and rich in cysteine

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290817.1 → NP_001277746.1  SPARC isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AA798908, AK148670, AK161229, BB857564, BE655213, BY781653, CJ132527
      Consensus CDS
      CCDS70189.1
      UniProtKB/TrEMBL
      Q3TXI6, Q5NCU4
      Related
      ENSMUSP00000104486.2, ENSMUST00000108858.8
      Conserved Domains (2) summary
      cd01328
      Location:69 → 150
      FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
      cd16235
      Location:153 → 292
      EFh_SPARC_SPARC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)

    2. NM_009242.5 → NP_033268.1  SPARC precursor

      See identical proteins and their annotated locations for NP_033268.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA798908, AK161229, BB857564, BE655213, BY781653, CJ132527
      Consensus CDS
      CCDS24712.1
      UniProtKB/Swiss-Prot
      P07214
      UniProtKB/TrEMBL
      Q3TXI6, Q5NCU5
      Related
      ENSMUSP00000018737.7, ENSMUST00000018737.13
      Conserved Domains (2) summary
      cd01328
      Location:70 → 151
      FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
      cd16235
      Location:154 → 293
      EFh_SPARC_SPARC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      55284985..55310906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07214.1 GenPept UniProtKB/Swiss-Prot:P07214

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