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    PDE4B phosphodiesterase 4B [ Homo sapiens (human) ]

    Gene ID: 5142, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PDE4Bprovided by HGNC
    Official Full Name
    phosphodiesterase 4Bprovided by HGNC
    Primary source
    HGNC:HGNC:8781
    See related
    Ensembl:ENSG00000184588 MIM:600127; AllianceGenome:HGNC:8781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPDE4; PDEIVB
    Summary
    This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in bone marrow (RPKM 18.7), brain (RPKM 17.6) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PDE4B in Genome Data Viewer
    Location:
    1p31.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (65792510..66374579)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (65669985..66252011)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (66258193..66840262)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leptin receptor Neighboring gene polypeptide N-acetylgalactosaminyltransferase 11 pseudogene Neighboring gene Sharpr-MPRA regulatory region 5730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1145 Neighboring gene RNA, 7SL, cytoplasmic 854, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:66306741-66307007 Neighboring gene NANOG hESC enhancer GRCh37_chr1:66469251-66469833 Neighboring gene PDE4B antisense RNA 1 Neighboring gene RNA, U4 small nuclear 88, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:66694092-66694275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1152 Neighboring gene Sharpr-MPRA regulatory region 6178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1153 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:66820269-66820769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1160 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:66866019-66867218 Neighboring gene uncharacterized LOC105378776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:66946325-66946955 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:66946956-66947585 Neighboring gene uncharacterized LOC124904196 Neighboring gene SH3GL interacting endocytic adaptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population. Numata S, et al. J Psychiatr Res, 2008 Nov. PMID 18329668
    2. Downregulation of phosphodiesterase 4B (PDE4B) activates protein kinase A and contributes to the progression of prostate cancer. Kashiwagi E, et al. Prostate, 2012 May 15. PMID 22529021
    3. Association of PDE4B polymorphisms and schizophrenia in Northwestern Han Chinese. Guan F, et al. Hum Genet, 2012 Jul. PMID 22160351
    4. Gene set enrichment analysis unveils the mechanism for the phosphodiesterase 4B control of glucocorticoid response in B-cell lymphoma. Kim SW, et al. Clin Cancer Res, 2011 Nov 1. PMID 21742807, Free PMC Article
    5. Insight into the phosphodiesterase mechanism from combined QM/MM free energy simulations. Wong KY, et al. FEBS J, 2011 Jul. PMID 21595828, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Anti-Inflammatory Effects of miR-369-3p via PDE4B in Intestinal Inflammatory Response.
      Title: Anti-Inflammatory Effects of miR-369-3p via PDE4B in Intestinal Inflammatory Response.
    2. Recent advances of Phosphodiesterase 4B in cancer.
      Title: Recent advances of Phosphodiesterase 4B in cancer.
    3. Loss of miR-26b-5p promotes gastric cancer progression via miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop.
      Title: Loss of miR-26b-5p promotes gastric cancer progression via miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop.
    4. Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
      Title: Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
    5. Population genetics of PDE4B (phosphodiesterase-4B) in neglected Native Americans: Implications for cancer pharmacogenetics.
      Title: Population genetics of PDE4B (phosphodiesterase-4B) in neglected Native Americans: Implications for cancer pharmacogenetics.
    6. qPCR Analysis Reveals Association of Differential Expression of SRR, NFKB1, and PDE4B Genes With Type 2 Diabetes Mellitus.
      Title: qPCR Analysis Reveals Association of Differential Expression of SRR, NFKB1, and PDE4B Genes With Type 2 Diabetes Mellitus.
    7. Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson's disease.
      Title: Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson's disease.
    8. circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.
      Title: circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.
    9. Cardiac Overexpression of PDE4B Blunts beta-Adrenergic Response and Maladaptive Remodeling in Heart Failure.
      Title: Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure.
    10. Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study.
      Title: Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study.
    Submit: New GeneRIF Correction See all GeneRIFs (58)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections.
    EBI GWAS Catalog
    Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.
    EBI GWAS Catalog
    Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia.
    EBI GWAS Catalog
    Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
    EBI GWAS Catalog
    The genetic architecture of economic and political preferences.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Cyclic AMP phosphodiesterase inhibitors AV411 and AV1013 inhibit HIV-1 replication and block HIV-1 Tat-induced neurotoxicity in human microglia, suggesting that cyclic AMP phosphodiesterase is involved in the Tat-mediated neurotoxicity PubMed
    tat HIV-1 Tat protein, in combination with anti-CD3/CD28 mAbs, promotes IL-2 production and proliferation of primary CD4+ T lymphocytes by recruiting cyclic nucleoside phosphodiesterase 4, resulting in increased susceptibility to HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126529, DKFZp686F2182

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity TAS
    Traceable Author Statement
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables calcium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to epinephrine stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to xenobiotic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in leukocyte migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of relaxation of cardiac muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neutrophil chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neutrophil homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cardiac muscle cell contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in excitatory synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of gamma-tubulin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    3',5'-cyclic-AMP phosphodiesterase 4B
    Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    cAMP-specific phosphodiesterase 4B
    dunce-like phosphodiesterase E4
    phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
    NP_001032416.1
    NP_001032417.1
    NP_001032418.1
    NP_001284369.1
    NP_001284370.1
    NP_001284371.1
    NP_002591.2
    XP_005270981.1
    XP_005270982.1
    XP_006710743.1
    XP_016856934.2
    XP_047278357.1
    XP_054192935.1
    XP_054192936.1
    XP_054192937.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029038.1 RefSeqGene

      Range
      5386..587065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001037339.2 → NP_001032416.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 2

      See identical proteins and their annotated locations for NP_001032416.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant a. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (2, also known as PDE4B2 or PDE32) has a shorter and distinct N-terminus when compared to isoform 1.
      Source sequence(s)
      AW519027, BC036108, DC399916, L12686, M97515
      Consensus CDS
      CCDS30743.1
      UniProtKB/TrEMBL
      B4DG71
      Related
      ENSP00000360084.5, ENST00000371045.9
      Conserved Domains (1) summary
      pfam00233
      Location:233 → 470
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_001037340.3 → NP_001032417.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 3

      See identical proteins and their annotated locations for NP_001032417.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant a. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (3, also known as PDE4B3) has a shorter and distinct N-terminus when compared to isoform 1.
      Source sequence(s)
      AB209081, BC036108, BC101480, L12686
      Consensus CDS
      CCDS30742.1
      UniProtKB/TrEMBL
      Q59GM8
      Related
      ENSP00000392947.2, ENST00000423207.6
      Conserved Domains (1) summary
      pfam00233
      Location:390 → 631
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. NM_001037341.2 → NP_001032418.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 1

      See identical proteins and their annotated locations for NP_001032418.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) differs in the 5' UTR, compared to variant a. Both variants a and d encode the same isoform (1, also known as PDE4B1 or Tm72).
      Source sequence(s)
      AW519027, BC046161, BC071607, BC101480, DA103627
      Consensus CDS
      CCDS632.1
      UniProtKB/Swiss-Prot
      A5YW33, O15443, Q07343, Q13945, Q5TEK4, Q5TEK5, Q5TEK6
      UniProtKB/TrEMBL
      X5DNX5, X5DR82
      Related
      ENSP00000332116.4, ENST00000329654.8
      Conserved Domains (1) summary
      pfam00233
      Location:405 → 646
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. NM_001297440.2 → NP_001284369.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (e) differs in the 5' UTR and lacks an alternate exon in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus when compared to isoform 1.
      Source sequence(s)
      BC036108, CR749667, DA103627, L12686, M97515
      UniProtKB/TrEMBL
      X5DR82
      Conserved Domains (2) summary
      pfam00233
      Location:313 → 553
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:74 → 189
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    5. NM_001297441.1 → NP_001284370.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (f) differs in the 5' UTR and contains multiple differences in the 5' coding region, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AL357273, AL590783, AW519027, BC036108, BF513098, KJ534917, L12686, M97515
      UniProtKB/TrEMBL
      X5DR82
      Conserved Domains (1) summary
      pfam00233
      Location:330 → 571
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    6. NM_001297442.2 → NP_001284371.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 6

      See identical proteins and their annotated locations for NP_001284371.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (g) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant a. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (6, also known as PDE4B5) has a shorter and distinct N-terminus when compared to isoform 1.
      Source sequence(s)
      AK290206, BC036108, L12686, M97515
      Consensus CDS
      CCDS72802.1
      UniProtKB/TrEMBL
      B4DG71
      Related
      ENSP00000432592.1, ENST00000480109.2
      Conserved Domains (2) summary
      pfam00233
      Location:172 → 413
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:16 → 48
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    7. NM_002600.4 → NP_002591.2  3',5'-cyclic-AMP phosphodiesterase 4B isoform 1

      See identical proteins and their annotated locations for NP_002591.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) encodes the longest isoform (1, also referred to as PDE4B1 or Tm72). Both variants a and d encode the same isoform.
      Source sequence(s)
      AA206316, AA453531, AL513493, BC046161, CN268011, DA126733, L20966
      Consensus CDS
      CCDS632.1
      UniProtKB/Swiss-Prot
      A5YW33, O15443, Q07343, Q13945, Q5TEK4, Q5TEK5, Q5TEK6
      UniProtKB/TrEMBL
      X5DNX5, X5DR82
      Related
      ENSP00000342637.4, ENST00000341517.9
      Conserved Domains (1) summary
      pfam00233
      Location:405 → 646
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      65792510..66374579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422401.1 → XP_047278357.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X3

    2. XM_017001445.2 → XP_016856934.2  3',5'-cyclic-AMP phosphodiesterase 4B isoform X1

    3. XM_005270925.3 → XP_005270982.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X3

      See identical proteins and their annotated locations for XP_005270982.1

      UniProtKB/TrEMBL
      B4DG71
      Conserved Domains (2) summary
      pfam00233
      Location:186 → 427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1 → 62
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    4. XM_006710680.4 → XP_006710743.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X2

      UniProtKB/TrEMBL
      B4DG71
      Conserved Domains (1) summary
      pfam00233
      Location:200 → 437
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. XM_005270924.4 → XP_005270981.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X3

      See identical proteins and their annotated locations for XP_005270981.1

      UniProtKB/TrEMBL
      B4DG71
      Conserved Domains (2) summary
      pfam00233
      Location:186 → 427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1 → 62
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      65669985..66252011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336960.1 → XP_054192935.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X1

    2. XM_054336961.1 → XP_054192936.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X2

    3. XM_054336962.1 → XP_054192937.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07343.1 GenPept UniProtKB/Swiss-Prot:Q07343

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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