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    myc.S MYC proto-oncogene, bHLH transcription factor S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 379052, updated on 11-Apr-2024

    Summary

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    Official Symbol
    myc.S
    Official Full Name
    MYC proto-oncogene, bHLH transcription factor S homeolog
    Primary source
    Xenbase:XB-GENE-6053022
    Locus tag
    XELAEV_180340073mg
    See related
    EnsemblRapid:ENSXLAG00005021538
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    myc; cmyc; myc1; mycI; Xcmyc; c-myc; myc-a; myc-b; X-cmyc
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    Genomic context

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    See myc.S in Genome Data Viewer
    Location:
    chromosome: 6S
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6S NC_054382.1 (127344309..127347795)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6S NC_030735.1 (118708290..118711828)

    Chromosome 6S - NC_054382.1Genomic Context describing neighboring genes Neighboring gene tribbles pseudokinase 1 S homeolog Neighboring gene protein LRATD2 Neighboring gene uncharacterized LOC108695380 Neighboring gene uncharacterized LOC121395181

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xenopus myc proto-oncogene during development: expression as a stable maternal mRNA uncoupled from cell division. Taylor MV, et al. EMBO J, 1986 Dec 20. PMID 3549280, Free PMC Article
    2. Expression of the c-myc proto-oncogene during development of Xenopus laevis. King MW, et al. Mol Cell Biol, 1986 Dec. PMID 3540613, Free PMC Article
    3. Developmentally regulated alternative splicing in the Xenopus laevis c-Myc gene creates an intron-1 containing c-Myc RNA present only in post-midblastula embryos. King MW. Nucleic Acids Res, 1991 Oct 25. PMID 1945855, Free PMC Article
    4. Differential expression of two Xenopus c-myc proto-oncogenes during development. Vriz S, et al. EMBO J, 1989 Dec 20. PMID 2686981, Free PMC Article
    5. Xenopus laevis c-myc I and II genes: molecular structure and developmental expression. Principaud E, et al. Nucleic Acids Res, 1991 Jun 11. PMID 2057364, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC52595, MGC130838

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional regulator Myc-A
    Names
    MYC oncprotein
    c-Myc I
    v-myc avian myelocytomatosis viral oncogene homolog S homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085896.1 → NP_001079365.1  transcriptional regulator Myc-A

      See identical proteins and their annotated locations for NP_001079365.1

      Status: PROVISIONAL

      Source sequence(s)
      BC110728
      UniProtKB/Swiss-Prot
      P06171, Q8AVZ1, Q91794
      UniProtKB/TrEMBL
      Q2TAU1
      Related
      ENSXLAP00005063271.1, ENSXLAT00005064733.1
      Conserved Domains (3) summary
      cd00083
      Location:333 → 392
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:6 → 326
      Myc_N; Myc amino-terminal region
      pfam02344
      Location:390 → 417
      Myc-LZ; Myc leucine zipper domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      127344309..127347795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06171.1 GenPept UniProtKB/Swiss-Prot:P06171

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