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    PXN paxillin [ Homo sapiens (human) ]

    Gene ID: 5829, updated on 3-Nov-2024

    Summary

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    Official Symbol
    PXNprovided by HGNC
    Official Full Name
    paxillinprovided by HGNC
    Primary source
    HGNC:HGNC:9718
    See related
    Ensembl:ENSG00000089159 MIM:602505; AllianceGenome:HGNC:9718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in placenta (RPKM 24.8), fat (RPKM 20.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PXN in Genome Data Viewer
    Location:
    12q24.23
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120210447..120265730, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120197626..120252894, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120648250..120703533, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene GCN1 activator of EIF2AK4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7132 Neighboring gene microRNA 4498 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:120622010-120623209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120635999-120636498 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120636618-120637559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7134 Neighboring gene Sharpr-MPRA regulatory region 12439 Neighboring gene PXN antisense RNA 1 Neighboring gene ribosomal protein lateral stalk subunit P0 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120653807-120654533 Neighboring gene uncharacterized LOC124903034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4943 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120662858-120663539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120664223-120664903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4944 Neighboring gene hESC enhancers GRCh37_chr12:120667255-120667814 and GRCh37_chr12:120667815-120668374 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:120668816-120670015 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120670055-120670614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120671735-120672294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120676424-120677054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120682649-120683475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7137 Neighboring gene ribosomal protein S20 pseudogene 31 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120697989-120698555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120717966-120718466 Neighboring gene hESC enhancers GRCh37_chr12:120727716-120728708 and GRCh37_chr12:120728709-120729700 Neighboring gene NME2 pseudogene 1 Neighboring gene RNA, U4 small nuclear 2 Neighboring gene sirtuin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions.
      Title: Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions.
    2. ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.
      Title: ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.
    3. Paxillin phase separation promotes focal adhesion assembly and integrin signaling.
      Title: Paxillin phase separation promotes focal adhesion assembly and integrin signaling.
    4. Effect of Paxillin Expression and Phosphorylation on Colorectal Cancer Prognosis and Metastasis.
      Title: Effect of Paxillin Expression and Phosphorylation on Colorectal Cancer Prognosis and Metastasis.
    5. Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation.
      Title: Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation.
    6. Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.
      Title: Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.
    7. Extraciliary OFD1 Is Involved in Melanocyte Survival through Cell Adhesion to ECM via Paxillin.
      Title: Extraciliary OFD1 Is Involved in Melanocyte Survival through Cell Adhesion to ECM via Paxillin.
    8. Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.
      Title: Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.
    9. An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.
      Title: An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.
    10. Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.
      Title: Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.
    Submit: New GeneRIF Correction See all GeneRIFs (183)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells PubMed
    Nef nef The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion PubMed
    nef The Nef/hnRNPK/PKC-delta/Hck protein complex increases paxillin phosphorylation at Y118 and activates and secretes TACE through Erk1/2 activation PubMed
    Tat tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
    tat HIV-1 Tat stimulates the phosphorylation of paxillin and its association with RAFTK, an effect linked to Tat-induced angiogenesis and AIDS-related Kaposi's sarcoma PubMed
    matrix gag HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16691

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropilin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables vinculin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to reactive oxygen species IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in growth hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal complex assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of microtubule associated complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    paxillin
    Names
    testicular tissue protein Li 134

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029820.1 RefSeqGene

      Range
      5042..60325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001080855.3 → NP_001074324.1  paxillin isoform 2

      See identical proteins and their annotated locations for NP_001074324.1

      Status: REVIEWED

      Source sequence(s)
      BC144410, BU500419, BX648777, DB472926
      Consensus CDS
      CCDS44997.1
      UniProtKB/Swiss-Prot
      B2RAI3, B7ZMB4, O14970, O14971, O60360, P49023, Q5HYA4
      UniProtKB/TrEMBL
      A0A140VJQ8, B3KVL0
      Related
      ENSP00000228307.7, ENST00000228307.11
      Conserved Domains (5) summary
      cd09338
      Location:476 → 528
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:417 → 468
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:535 → 586
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:358 → 410
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family

    2. NM_001243756.2 → NP_001230685.1  paxillin isoform 3

      See identical proteins and their annotated locations for NP_001230685.1

      Status: REVIEWED

      Source sequence(s)
      AC004263
      Consensus CDS
      CCDS58281.1
      UniProtKB/TrEMBL
      B3KVL0
      Related
      ENSP00000267257.7, ENST00000267257.11
      Conserved Domains (5) summary
      cd09338
      Location:490 → 542
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:431 → 482
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:549 → 600
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:372 → 424
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family

    3. NM_001385981.1 → NP_001372910.1  paxillin isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC004263
      Consensus CDS
      CCDS91759.1
      UniProtKB/TrEMBL
      A0A1B0GTU4
      Related
      ENSP00000489840.1, ENST00000637617.2
      Conserved Domains (6) summary
      cd09338
      Location:966 → 1018
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:907 → 958
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:1025 → 1076
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      PHA03247
      Location:314 → 606
      PHA03247; large tegument protein UL36; Provisional
      cd09336
      Location:848 → 900
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family

    4. NM_001385982.1 → NP_001372911.1  paxillin isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC004263
      Conserved Domains (5) summary
      cd09338
      Location:874 → 926
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:815 → 866
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:933 → 984
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:756 → 808
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family

    5. NM_001385983.1 → NP_001372912.1  paxillin isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC004263
      Conserved Domains (5) summary
      cd09338
      Location:872 → 924
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:813 → 864
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:931 → 982
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:754 → 806
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family

    6. NM_001385984.1 → NP_001372913.1  paxillin isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC004263
      Conserved Domains (6) summary
      cd09338
      Location:785 → 837
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:726 → 777
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:844 → 895
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      PHA03247
      Location:314 → 553
      PHA03247; large tegument protein UL36; Provisional
      cd09336
      Location:667 → 719
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family

    7. NM_001385985.1 → NP_001372914.1  paxillin isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC004263
      Conserved Domains (6) summary
      cd09338
      Location:737 → 789
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:678 → 729
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:796 → 847
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      PHA03247
      Location:314 → 553
      PHA03247; large tegument protein UL36; Provisional
      cd09336
      Location:619 → 671
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family

    8. NM_001385986.1 → NP_001372915.1  paxillin isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC004263
      Conserved Domains (6) summary
      cd09338
      Location:625 → 677
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:566 → 617
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:684 → 735
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      PHA03307
      Location:91 → 459
      PHA03307; transcriptional regulator ICP4; Provisional
      cd09336
      Location:507 → 559
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family

    9. NM_001385987.1 → NP_001372916.1  paxillin isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC004263
      UniProtKB/TrEMBL
      B3KVL0
      Conserved Domains (5) summary
      cd09338
      Location:579 → 631
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:520 → 571
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:638 → 689
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:461 → 513
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family

    10. NM_001385988.1 → NP_001372917.1  paxillin isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC004263
      UniProtKB/TrEMBL
      B3KVL0
      Conserved Domains (4) summary
      cd09407
      Location:465 → 516
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09336
      Location:406 → 458
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family
      cl02475
      Location:524 → 550
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    11. NM_001385989.1 → NP_001372918.1  paxillin isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC004263
      UniProtKB/TrEMBL
      B3KVL0
      Conserved Domains (4) summary
      cd09407
      Location:415 → 466
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09336
      Location:356 → 408
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family
      cl02475
      Location:474 → 500
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    12. NM_001385990.1 → NP_001372919.1  paxillin isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC004263
      Conserved Domains (4) summary
      cd09407
      Location:383 → 434
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09336
      Location:324 → 376
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family
      cl02475
      Location:442 → 468
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    13. NM_001410986.1 → NP_001397915.1  paxillin isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC004263
      Consensus CDS
      CCDS91758.1
      UniProtKB/TrEMBL
      F5GZ78
      Related
      ENSP00000443887.1, ENST00000536957.5

    14. NM_002859.4 → NP_002850.2  paxillin isoform 1

      See identical proteins and their annotated locations for NP_002850.2

      Status: REVIEWED

      Source sequence(s)
      BC136794, BC144410, BU500419, BX648777, DB472926
      Consensus CDS
      CCDS44996.1
      UniProtKB/TrEMBL
      B3KVL0
      Related
      ENSP00000391283.2, ENST00000424649.6
      Conserved Domains (5) summary
      cd09338
      Location:442 → 494
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:383 → 434
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:501 → 552
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:324 → 376
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family

    15. NM_025157.5 → NP_079433.3  paxillin isoform 4

      See identical proteins and their annotated locations for NP_079433.3

      Status: REVIEWED

      Source sequence(s)
      AC004263, BC136794, BC144410, BU500419, BX648777, DA565031
      Consensus CDS
      CCDS44998.1
      UniProtKB/Swiss-Prot
      P49023
      Related
      ENSP00000395536.2, ENST00000458477.6
      Conserved Domains (4) summary
      cd09338
      Location:309 → 361
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09336
      Location:191 → 243
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      cl02475
      Location:250 → 301
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam03535
      Location:1 → 120
      Paxillin; Paxillin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      120210447..120265730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429246.1 → XP_047285202.1  paxillin isoform X15

    2. XM_047429241.1 → XP_047285197.1  paxillin isoform X9

    3. XM_047429240.1 → XP_047285196.1  paxillin isoform X8

    4. XM_047429239.1 → XP_047285195.1  paxillin isoform X7

    5. XM_006719532.3 → XP_006719595.1  paxillin isoform X2

      Conserved Domains (5) summary
      cd09338
      Location:1014 → 1066
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:955 → 1006
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:1073 → 1124
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:896 → 948
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54 → 253
      Paxillin; Paxillin family

    6. XM_011538622.2 → XP_011536924.1  paxillin isoform X3

      See identical proteins and their annotated locations for XP_011536924.1

      Conserved Domains (5) summary
      cd09338
      Location:881 → 933
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:822 → 873
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:940 → 991
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:763 → 815
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:1 → 120
      Paxillin; Paxillin family

    7. XM_047429236.1 → XP_047285192.1  paxillin isoform X1

    8. XM_047429250.1 → XP_047285206.1  paxillin isoform X19

    9. XM_047429243.1 → XP_047285199.1  paxillin isoform X12

    10. XM_047429249.1 → XP_047285205.1  paxillin isoform X18

    11. XM_047429242.1 → XP_047285198.1  paxillin isoform X11

    12. XM_047429244.1 → XP_047285200.1  paxillin isoform X14

    13. XM_017019742.3 → XP_016875231.1  paxillin isoform X17

      UniProtKB/TrEMBL
      B3KVL0
      Conserved Domains (5) summary
      cd09338
      Location:448 → 500
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:389 → 440
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:507 → 558
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:330 → 382
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:60 → 259
      Paxillin; Paxillin family

    14. XM_017019739.3 → XP_016875228.1  paxillin isoform X10

      UniProtKB/TrEMBL
      B3KVL0
      Conserved Domains (5) summary
      cd09338
      Location:496 → 548
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:437 → 488
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:555 → 606
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:378 → 430
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:60 → 259
      Paxillin; Paxillin family

    15. XM_017019740.3 → XP_016875229.1  paxillin isoform X13

      UniProtKB/TrEMBL
      B3KVL0
      Conserved Domains (5) summary
      cd09338
      Location:482 → 534
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:423 → 474
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:541 → 592
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:364 → 416
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:60 → 259
      Paxillin; Paxillin family

    16. XM_047429252.1 → XP_047285208.1  paxillin isoform X21

    17. XM_047429253.1 → XP_047285209.1  paxillin isoform X22

    18. XM_047429251.1 → XP_047285207.1  paxillin isoform X20

    19. XM_047429238.1 → XP_047285194.1  paxillin isoform X6

    20. XM_047429237.1 → XP_047285193.1  paxillin isoform X5

    21. XM_047429248.1 → XP_047285204.1  paxillin isoform X16

    22. XM_017019732.3 → XP_016875221.2  paxillin isoform X4

    RNA

    1. XR_002957365.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      120197626..120252894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372755.1 → XP_054228730.1  paxillin isoform X15

    2. XM_054372748.1 → XP_054228723.1  paxillin isoform X9

    3. XM_054372747.1 → XP_054228722.1  paxillin isoform X8

    4. XM_054372741.1 → XP_054228716.1  paxillin isoform X7

    5. XM_054372732.1 → XP_054228707.1  paxillin isoform X2

    6. XM_054372735.1 → XP_054228710.1  paxillin isoform X3

    7. XM_054372730.1 → XP_054228705.1  paxillin isoform X1

    8. XM_054372758.1 → XP_054228733.1  paxillin isoform X19

    9. XM_054372751.1 → XP_054228726.1  paxillin isoform X12

    10. XM_054372733.1 → XP_054228708.1  paxillin isoform X24

    11. XM_054372757.1 → XP_054228732.1  paxillin isoform X18

    12. XM_054372750.1 → XP_054228725.1  paxillin isoform X11

    13. XM_054372754.1 → XP_054228729.1  paxillin isoform X14

    14. XM_054372746.1 → XP_054228721.1  paxillin isoform X35

    15. XM_054372743.1 → XP_054228718.1  paxillin isoform X32

    16. XM_054372731.1 → XP_054228706.1  paxillin isoform X23

    17. XM_054372756.1 → XP_054228731.1  paxillin isoform X17

    18. XM_054372749.1 → XP_054228724.1  paxillin isoform X10

    19. XM_054372753.1 → XP_054228728.1  paxillin isoform X36

    20. XM_054372745.1 → XP_054228720.1  paxillin isoform X34

    21. XM_054372752.1 → XP_054228727.1  paxillin isoform X13

    22. XM_054372744.1 → XP_054228719.1  paxillin isoform X33

    23. XM_054372742.1 → XP_054228717.1  paxillin isoform X31

    24. XM_054372740.1 → XP_054228715.1  paxillin isoform X30

    25. XM_054372739.1 → XP_054228714.1  paxillin isoform X29

    26. XM_054372738.1 → XP_054228713.1  paxillin isoform X28

    27. XM_054372737.1 → XP_054228712.1  paxillin isoform X27

    28. XM_054372734.1 → XP_054228709.1  paxillin isoform X25

    29. XM_054372736.1 → XP_054228711.1  paxillin isoform X26

    RNA

    1. XR_008488651.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49023.3 GenPept UniProtKB/Swiss-Prot:P49023

    Gene LinkOut

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