Hsf1 heat shock factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hsf1provided by MGI
Official Full Name: heat shock factor 1provided by MGI
Primary source: MGI:MGI:96238
See related: Ensembl:ENSMUSG00000022556 AllianceGenome:MGI:96238
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HSTF; HSTF 1; Hsf1beta; Hsf1alpha
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of gene expression. Acts upstream of or within several processes, including embryo development; negative regulation of tumor necrosis factor production; and response to lipopolysaccharide. Located in cytoplasm and pronucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 47.3), thymus adult (RPKM 42.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 35.95 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (76361562..76385355)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (76477362..76501155)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deactivation of the Unfolded Protein Response Aggravated Renal AA Amyloidosis in HSF1 Deficiency Mice.
Title: Deactivation of the Unfolded Protein Response Aggravated Renal AA Amyloidosis in HSF1 Deficiency Mice.
Heat shock factor 1 drives regulatory T-cell induction to limit murine intestinal inflammation.
Title: Heat shock factor 1 drives regulatory T-cell induction to limit murine intestinal inflammation.
Disrupted HSF1 regulation in normal and exceptional brain aging.
Title: Disrupted HSF1 regulation in normal and exceptional brain aging.
Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation.
Title: Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation.
HSF1 enhances the attenuation of exosomes from mesenchymal stem cells to hemorrhagic shock induced lung injury by altering the protein profile of exosomes.
Title: HSF1 enhances the attenuation of exosomes from mesenchymal stem cells to hemorrhagic shock induced lung injury by altering the protein profile of exosomes.
HSF1 inhibits microglia activation to attenuate neuroinflammation via regulating miR-214-3p and NFATc2 in Parkinson's disease.
Title: HSF1 inhibits microglia activation to attenuate neuroinflammation via regulating miR-214-3p and NFATc2 in Parkinson's disease.
Heat shock factor 1 induces a short burst of transcription of the clock gene Per2 during interbout arousal in mammalian hibernation.
Title: Heat shock factor 1 induces a short burst of transcription of the clock gene Per2 during interbout arousal in mammalian hibernation.
HSF1 promotes CD69[+] Treg differentiation to inhibit colitis progression.
Title: HSF1 promotes CD69(+) Treg differentiation to inhibit colitis progression.
Heat shock factor HSF1 regulates BDNF gene promoters upon acute stress in the hippocampus, together with pCREB.
Title: Heat shock factor HSF1 regulates BDNF gene promoters upon acute stress in the hippocampus, together with pCREB.
Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease.
Title: Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease.

Submit: New GeneRIF Correction See all GeneRIFs (179)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237330

AA960185 (e-PCR)
- UniSTS:160467

Hsf1 (e-PCR), detects polymorphism
- UniSTS:546553

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables STAT family protein binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables general transcription initiation factor binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific single stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables translation elongation factor binding	ISO Inferred from Sequence Orthology more info
enables translation elongation factor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to angiotensin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cadmium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to copper ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to copper ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to diamide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to diamide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gamma radiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gamma radiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in cellular response to radiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to sodium arsenite	ISO Inferred from Sequence Orthology more info
involved_in cellular response to sodium arsenite	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to unfolded protein	ISO Inferred from Sequence Orthology more info
involved_in cellular response to unfolded protein	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic process involved in female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within female meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inclusion body assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic DNA fragmentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inclusion body assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress granule assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of spindle checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to testosterone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear stress granule	ISO Inferred from Sequence Orthology more info
located_in nuclear stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in pronucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein folding chaperone complex	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: heat shock factor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001331152.1 → NP_001318081.1 heat shock factor protein 1 isoform gammaalpha

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (gammaalpha).

Source sequence(s)

AC157566, AK075651, BQ445304, BU925102, CB245398, CK622418

UniProtKB/TrEMBL

A0A075F6C2
NM_001331153.1 → NP_001318082.1 heat shock factor protein 1 isoform gammabeta

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform gammabeta which is shorter compared to isoform gammaalpha.

Source sequence(s)

AC157566, AK075651, BQ445304, BU925102, CB245398

Consensus CDS

CCDS88785.1

UniProtKB/TrEMBL

A0A075F5C6, A0A2R8W6L8

Related

ENSMUSP00000154638.2, ENSMUST00000228371.2
NM_001331154.1 → NP_001318083.1 heat shock factor protein 1 isoform alpha

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform alpha which is shorter compared to isoform gammaalpha.

Source sequence(s)

AC157566, AK075651, BQ445304, BU925102, CB245398, CK622418

Consensus CDS

CCDS88787.1

UniProtKB/Swiss-Prot

O70462, P38532

UniProtKB/TrEMBL

A0A075F891, A0A2R8W6L8

Related

ENSMUSP00000154602.2, ENSMUST00000227478.2
NM_001331214.1 → NP_001318143.1 heat shock factor protein 1 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate internal exon and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 5, which has a shorter and distinct C-terminus, compared to isoform gammaalpha.

Source sequence(s)

AC157566, AK075651, BQ445304, BU925102, CB245398

Consensus CDS

CCDS88786.1

UniProtKB/TrEMBL

A0A2R8W6L8, Q52L52

Related

ENSMUSP00000154328.2, ENSMUST00000226872.2
NM_008296.3 → NP_032322.1 heat shock factor protein 1 isoform beta

See identical proteins and their annotated locations for NP_032322.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform beta which is shorter compared to isoform gammaalpha.

Source sequence(s)

AC157566, AK075651, BQ445304, BU925102, CB245398

Consensus CDS

CCDS27572.1

UniProtKB/TrEMBL

A0A075F882, A0A2R8W6L8

Related

ENSMUSP00000072617.6, ENSMUST00000072838.6

Conserved Domains (2) summary

smart00415
Location:14 → 118

HSF; heat shock factor

pfam06546
Location:258 → 503

Vert_HS_TF; Vertebrate heat shock transcription factor

RNA

NR_138588.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks two alternate internal exons and retains an intron in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC157566, AK075651, AK089144, BG694608, BQ445304, BU925102, CB245398

Related

ENSMUST00000228868.2
NR_138589.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks multiple alternate internal exons and uses an alternate splice site in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant gammaalpha, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC157566, AK075651, AK082507, BQ445304, BU925102, CB245398, CK622418
NR_177205.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks multiple alternate internal exons and uses an alternate splice site in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant gammaalpha, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC157566

Related

ENSMUST00000226860.2
NR_177206.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (10) lacks multiple alternate internal exons and uses an alternate splice site in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant gammaalpha, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC157566
NR_177207.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (9) lacks multiple alternate internal exons and uses an alternate splice site in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant gammaalpha, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC157566

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

76361562..76385355

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159165.1 → XP_036015058.1 heat shock factor protein 1 isoform X2

Conserved Domains (1) summary

pfam06546
Location:47 → 314

Vert_HS_TF; Vertebrate heat shock transcription factor
XM_006520476.5 → XP_006520539.1 heat shock factor protein 1 isoform X3

Conserved Domains (1) summary

pfam06546
Location:47 → 292

Vert_HS_TF; Vertebrate heat shock transcription factor
XM_006520474.5 → XP_006520537.1 heat shock factor protein 1 isoform X1

See identical proteins and their annotated locations for XP_006520537.1

Conserved Domains (1) summary

pfam06546
Location:47 → 342

Vert_HS_TF; Vertebrate heat shock transcription factor
XM_006520475.5 → XP_006520538.1 heat shock factor protein 1 isoform X1

See identical proteins and their annotated locations for XP_006520538.1

Conserved Domains (1) summary

pfam06546
Location:47 → 342

Vert_HS_TF; Vertebrate heat shock transcription factor