U.S. flag

An official website of the United States government

Links from Nucleotide

    • Showing Current items.

    Hipk4 homeodomain interacting protein kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308449, updated on 14-Nov-2024

    Summary

    Official Symbol
    Hipk4provided by RGD
    Official Full Name
    homeodomain interacting protein kinase 4provided by RGD
    Primary source
    RGD:1307541
    See related
    EnsemblRapid:ENSRNOG00000020835 AllianceGenome:RGD:1307541
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone kinase activity; protein serine/threonine kinase activity; and protein tyrosine kinase activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within peptidyl-serine phosphorylation; protein autophosphorylation; and regulation of signal transduction by p53 class mediator. Predicted to be active in cytoplasm and nucleus. Orthologous to human HIPK4 (homeodomain interacting protein kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 103.3), Brain (RPKM 24.5) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hipk4 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (91938308..91948680)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (82810708..82821080)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (84328114..84338486)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene SERTA domain containing 1 Neighboring gene transmembrane protein 258, pseudogene 4 Neighboring gene periaxin Neighboring gene phospholipase D family, member 3 Neighboring gene similar to human chromosome 19 open reading frame 47 Neighboring gene large ribosomal subunit protein uL22-like Neighboring gene AKT serine/threonine kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables histone kinase activity  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein tyrosine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    homeodomain-interacting protein kinase 4
    NP_001019947.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024776.1NP_001019947.1  homeodomain-interacting protein kinase 4

      See identical proteins and their annotated locations for NP_001019947.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098070
      UniProtKB/Swiss-Prot
      Q4V793
      Related
      ENSRNOP00000028266.3, ENSRNOT00000028266.7
      Conserved Domains (1) summary
      cl21453
      Location:11347
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      91938308..91948680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.