Gpr4 G protein-coupled receptor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr4provided by RGD
Official Full Name: G protein-coupled receptor 4provided by RGD
Primary source: RGD:1311604
See related: EnsemblRapid:ENSRNOG00000016362 AllianceGenome:RGD:1311604
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of Rho protein signal transduction; and response to acidic pH. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; blood vessel development; and negative regulation of angiogenesis. Predicted to be active in plasma membrane. Orthologous to human GPR4 (G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 15.7), Lung (RPKM 12.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (87993398..88004568)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (78865376..78877126)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80125639..80136786)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes.
Title: Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes.
Involvement of the G-Protein-Coupled Receptor 4 in the Increased Expression of RANK/RANKL/OPG System and Neurotrophins by Nucleus Pulposus Cells under the Degenerated Intervertebral Disc-Like Acidic Microenvironment.
Title: Involvement of the G-Protein-Coupled Receptor 4 in the Increased Expression of RANK/RANKL/OPG System and Neurotrophins by Nucleus Pulposus Cells under the Degenerated Intervertebral Disc-Like Acidic Microenvironment.
Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells.
Title: Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells.
Results indicate that GPR4 is expressed by multiple neuronal populations and endothelium and that its pH sensitivity is affected by level of expression and l-lactic acid (LL). GPR4 antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this effect is absent under anaesthesia, possibly due to the inhibitory effect of LL on GPR4.
Title: CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.

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General gene information

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Markers

UniSTS:498495 (e-PCR)
- UniSTS:498495

Gpr4 (e-PCR), detects polymorphism
- UniSTS:498495

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within angiogenesis involved in wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glomerular mesangial cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular permeability	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to acidic pH	ISO Inferred from Sequence Orthology more info
involved_in response to acidic pH	ISO Inferred from Sequence Orthology more info
involved_in response to acidic pH	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: G-protein coupled receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025680.1 → NP_001020851.1 G-protein coupled receptor 4

See identical proteins and their annotated locations for NP_001020851.1

Status: PROVISIONAL

Source sequence(s)

BC099196

UniProtKB/Swiss-Prot

Q4KLH9

UniProtKB/TrEMBL

A6J8L2

Conserved Domains (1) summary

cd15366
Location:20 → 299

7tmA_GPR4; proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

87993398..88004568

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228418.3 → XP_006228480.1 G-protein coupled receptor 4 isoform X1

See identical proteins and their annotated locations for XP_006228480.1

UniProtKB/Swiss-Prot

Q4KLH9

UniProtKB/TrEMBL

A6J8L2

Related

ENSRNOP00000101552.1, ENSRNOT00000153217.1

Conserved Domains (1) summary

cd15366
Location:20 → 299

7tmA_GPR4; proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors