PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: PIK3CAprovided by HGNC
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaprovided by HGNC
Primary source: HGNC:HGNC:8975
See related: Ensembl:ENSG00000121879 MIM:171834; AllianceGenome:HGNC:8975
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HMH; MCM; CCM4; CWS5; MCAP; PI3K; CLAPO; CLOVE; MCMTC; PI3K-alpha; p110-alpha
Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]
Expression: Ubiquitous expression in fat (RPKM 10.3), gall bladder (RPKM 7.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q26.32

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (179148126..179240093)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (181951917..182043930)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (178866145..178957881)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.
Title: Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.
Defining the transcriptome of PIK3CA-altered cells in a human capillary malformation using single cell long-read sequencing.
Title: Defining the transcriptome of PIK3CA-altered cells in a human capillary malformation using single cell long-read sequencing.
Analysis of PIK3CA mutations in the primary and recurrent tumors of hormone receptor positive/human epidermal growth factor receptor 2 negative breast cancer.
Title: Analysis of PIK3CA mutations in the primary and recurrent tumors of hormone receptor positive/human epidermal growth factor receptor 2 negative breast cancer.
Constitutional Mutation of PIK3CA: A Variant of Cowden Syndrome?
Title: Constitutional Mutation of PIK3CA: A Variant of Cowden Syndrome?
PIK3CA Mutated Colorectal Cancers Without KRAS, NRAS and BRAF Mutations Possess Common and Potentially Targetable Mutations in Epigenetic Modifiers and DNA Damage Response Genes.
Title: PIK3CA Mutated Colorectal Cancers Without KRAS, NRAS and BRAF Mutations Possess Common and Potentially Targetable Mutations in Epigenetic Modifiers and DNA Damage Response Genes.
Association of ESR1 Germline Variants with TP53 Somatic Variants in Breast Tumors in a Genome-wide Study.
Title: Association of ESR1 Germline Variants with TP53 Somatic Variants in Breast Tumors in a Genome-wide Study.
PI 3-Kinase and the Histone Methyl-Transferase KMT2D Collaborate to Induce Arp2/3-Dependent Migration of Mammary Epithelial Cells.
Title: PI 3-Kinase and the Histone Methyl-Transferase KMT2D Collaborate to Induce Arp2/3-Dependent Migration of Mammary Epithelial Cells.
Delineation of the phenotypes and genotypes of PIK3CA-related overgrowth spectrum in East asians.
Title: Delineation of the phenotypes and genotypes of PIK3CA-related overgrowth spectrum in East asians.
PIK3CA inhibition in models of proliferative glomerulonephritis and lupus nephritis.
Title: PIK3CA inhibition in models of proliferative glomerulonephritis and lupus nephritis.
Cryo-EM structures reveal two allosteric inhibition modes of PI3Kalpha[H1047R] involving a re-shaping of the activation loop.
Title: Cryo-EM structures reveal two allosteric inhibition modes of PI3Kα(H1047R) involving a re-shaping of the activation loop.

Submit: New GeneRIF Correction See all GeneRIFs (1474)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Cerebral cavernous malformation 4 MedGen: C5561991 OMIM: 619538 GeneReviews: Familial Cerebral Cavernous Malformation	not available
CLAPO syndrome MedGen: C2751313 OMIM: 613089 GeneReviews: PIK3CA-Related Overgrowth Spectrum	not available
CLOVES syndrome MedGen: C2752042 OMIM: 612918 GeneReviews: PIK3CA-Related Overgrowth Spectrum	not available
Colorectal cancer MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome	not available
Congenital macrodactylia MedGen: C0265552 OMIM: 155500 GeneReviews: PIK3CA-Related Overgrowth Spectrum	not available
Cowden syndrome 5 MedGen: C3554518 OMIM: 615108 GeneReviews: PIK3CA-Related Overgrowth Spectrum	not available
Epidermal nevus MedGen: C0334082 OMIM: 162900 GeneReviews: PIK3CA-Related Overgrowth Spectrum	not available
Familial cancer of breast MedGen: C0346153 OMIM: 114480 GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer	not available
Gastric cancer MedGen: C0024623 OMIM: 613659 GeneReviews: Not available	not available
Hepatocellular carcinoma MedGen: C2239176 OMIM: 114550 GeneReviews: Not available	not available
Lung cancer MedGen: C0242379 OMIM: 211980 GeneReviews: Not available	not available
Megalencephaly-capillary malformation-polymicrogyria syndrome MedGen: C1865285 OMIM: 602501 GeneReviews: PIK3CA-Related Overgrowth Spectrum	not available
Ovarian neoplasm MedGen: C0919267 GeneReviews: Not available	not available
Seborrheic keratosis MedGen: C0022603 OMIM: 182000 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2015-03-12) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2015-03-12) ClinGen Genome Curation Page

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes	PubMed
	env	HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors	PubMed
	env	Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling	PubMed
	env	Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production	PubMed
	env	CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn	PubMed
	env	CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway	PubMed
	env	Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways	PubMed
	env	HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity	PubMed
	env	PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells	PubMed
Nef	nef	HIV-1 Nef interacts with AKT1 and PI3K via its C and N terminal extremity, respectively	PubMed
	nef	HIV-1 Nef activation of AKT1 is mediated by PI3K in peripheral blood lymphocytes	PubMed
	nef	HIV-1 Nef involves the PI3K-PKC pathway for induction of IL6 and CXCL8 (IL8) expression	PubMed
	nef	HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells	PubMed
	nef	In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase	PubMed
	nef	The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production	PubMed
	nef	Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K	PubMed
	nef	The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression	PubMed
Tat	tat	HIV-1 Tat and cocaine treatment activates PI3K and AKT in human pulmonary arterial smooth muscle cells	PubMed
	tat	HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells	PubMed
	tat	HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells	PubMed
	tat	PI3K/Akt, TRPC, and GSK3beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells	PubMed
	tat	Arctigenin regulates the upstream PI3K enzyme from converting PIP2 to PIP3 in Tat-expressing CHME5 cells	PubMed
	tat	Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation	PubMed
	tat	HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells	PubMed
	tat	HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K)	PubMed
	tat	Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway	PubMed
	tat	HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis	PubMed
	tat	Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex	PubMed
	tat	HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase	PubMed
	tat	Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase	PubMed
Vpr	vpr	PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) is involved in HIV-1 Vpr induced upregulation of IL6 in astrocytes	PubMed
	vpr	PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) is involved in HIV-1 Vpr induced upregulation of CXCL8 (IL8) in astrocytes	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-12912 (e-PCR)
- UniSTS:43777

PIK3CA_4031 (e-PCR)
- UniSTS:462410

GDB:596369 (e-PCR)
- UniSTS:158097

GDB:596374 (e-PCR)
- UniSTS:158098

RH70978 (e-PCR)
- UniSTS:19672

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-phosphatidylinositol-3-kinase activity	TAS Traceable Author Statement more info	PubMed
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS Traceable Author Statement more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in T cell costimulation	TAS Traceable Author Statement more info
involved_in T cell receptor signaling pathway	TAS Traceable Author Statement more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in adipose tissue development	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in anoikis	NAS Non-traceable Author Statement more info	PubMed
involved_in autosome genomic imprinting	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrostatic pressure	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in endothelial cell migration	TAS Traceable Author Statement more info	PubMed
involved_in energy homeostasis	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	TAS Traceable Author Statement more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of actin filament depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of anoikis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of anoikis	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of fibroblast apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macroautophagy	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet activation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of TOR signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein localization to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin filament organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular respiration	IEA Inferred from Electronic Annotation more info
involved_in regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in relaxation of cardiac muscle	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to L-leucine	IEA Inferred from Electronic Annotation more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to butyrate	IEA Inferred from Electronic Annotation more info
involved_in response to dexamethasone	IEA Inferred from Electronic Annotation more info
involved_in response to muscle inactivity	IEA Inferred from Electronic Annotation more info
involved_in response to muscle stretch	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular endothelial growth factor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vasculature development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intercalated disc	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of phosphatidylinositol 3-kinase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of phosphatidylinositol 3-kinase complex, class IA	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IA	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	IPI Inferred from Physical Interaction more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	NAS Non-traceable Author Statement more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IB	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Names: PI3-kinase p110 subunit alpha; mutant phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphoinositide 3-kinase alpha; phosphoinositide-3-kinase, catalytic, alpha polypeptide; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA

NP_006209.2

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.11.1

XP_006713721.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.11.1

XP_054202817.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.11.1

XP_054202818.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.11.1

XP_054202819.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.11.1

XP_054202820.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.11.1

XP_054202821.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.11.1

XP_054202822.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.11.1

XP_054202823.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012113.2 RefSeqGene

Range

5001..91190

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_310

mRNA and Protein(s)

NM_006218.4 → NP_006209.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

See identical proteins and their annotated locations for NP_006209.2

Status: REVIEWED

Source sequence(s)

AC076966, AI379480, AU129890, AW445128, BQ228953, BX437219, BX473473, BX484734, U79143

Consensus CDS

CCDS43171.1

UniProtKB/Swiss-Prot

P42336, Q14CW1, Q99762

UniProtKB/TrEMBL

Q4LE51

Related

ENSP00000263967.3, ENST00000263967.4

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

179148126..179240093

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006713658.5 → XP_006713721.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

See identical proteins and their annotated locations for XP_006713721.1

UniProtKB/Swiss-Prot

P42336, Q14CW1, Q99762

UniProtKB/TrEMBL

Q4LE51

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

181951917..182043930

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054346842.1 → XP_054202817.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

UniProtKB/Swiss-Prot

P42336, Q14CW1, Q99762
XM_054346845.1 → XP_054202820.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

UniProtKB/Swiss-Prot

P42336, Q14CW1, Q99762
XM_054346848.1 → XP_054202823.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

UniProtKB/Swiss-Prot

P42336, Q14CW1, Q99762
XM_054346846.1 → XP_054202821.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

UniProtKB/Swiss-Prot

P42336, Q14CW1, Q99762
XM_054346844.1 → XP_054202819.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

UniProtKB/Swiss-Prot

P42336, Q14CW1, Q99762
XM_054346847.1 → XP_054202822.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

UniProtKB/Swiss-Prot

P42336, Q14CW1, Q99762
XM_054346843.1 → XP_054202818.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

UniProtKB/Swiss-Prot

P42336, Q14CW1, Q99762