Psmd14 proteasome 26S subunit, non-ATPase 14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Psmd14provided by RGD
Official Full Name: proteasome 26S subunit, non-ATPase 14provided by RGD
Primary source: RGD:1594532
See related: EnsemblRapid:ENSRNOG00000061129 AllianceGenome:RGD:1594532
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable endopeptidase activator activity; metal-dependent deubiquitinase activity; and proteasome binding activity. Involved in response to ethanol. Part of cytosolic proteasome complex. Orthologous to human PSMD14 (proteasome 26S subunit, non-ATPase 14). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Thymus (RPKM 334.4), Brain (RPKM 282.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (66662933..66755666)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (46254338..46347076)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (47578449..47673330)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation.
Title: Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation.
translocation from synapse to the nucleus is involved in regulation of Tbr-1 function in postnatal and adult brains
Title: Cytoplasmic distribution of T-box transcription factor Tbr-1 in adult rodent brain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143528 (e-PCR)
- UniSTS:232774

AU048604 (e-PCR)
- UniSTS:145054

D3Chm12 (e-PCR)
- UniSTS:265389

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activator activity	ISO Inferred from Sequence Orthology more info
enables metal-dependent deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal-dependent deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of cytosolic proteasome complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome accessory complex	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, lid subcomplex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 14

Names: proteasome (prosome, macropain) 26S subunit, non-ATPase, 14

NP_001020860.1

EC 3.4.19.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025689.1 → NP_001020860.1 26S proteasome non-ATPase regulatory subunit 14

See identical proteins and their annotated locations for NP_001020860.1

Status: PROVISIONAL

Source sequence(s)

BC097427

UniProtKB/TrEMBL

A0A0G2JZJ1, A0A8I6A8J5, A6HLU7, F1LMW6, Q4V8E2

Related

ENSRNOP00000071068.3, ENSRNOT00000082769.3

Conserved Domains (1) summary

cd08069
Location:21 → 286

MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5