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    Rin3 Ras and Rab interactor 3 [ Mus musculus (house mouse) ]

    Gene ID: 217835, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rin3provided by MGI
    Official Full Name
    Ras and Rab interactor 3provided by MGI
    Primary source
    MGI:MGI:2385708
    See related
    Ensembl:ENSMUSG00000044456 AllianceGenome:MGI:2385708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6430500K07
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in signal transduction and vesicle-mediated transport. Predicted to act upstream of or within negative regulation of receptor internalization and regulation of vesicle size. Located in axon; dendrite; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human RIN3 (Ras and Rab interactor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 24.0), lung adult (RPKM 16.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rin3 in Genome Data Viewer
    Location:
    12 E; 12 51.45 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102248572..102358982)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102282840..102390854)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33093 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 Neighboring gene cleavage and polyadenylation specific factor 2 Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Neighboring gene U3B small nuclear RNA pseudogene 3 Neighboring gene predicted gene, 25203 Neighboring gene STARR-seq mESC enhancer starr_33096 Neighboring gene STARR-positive B cell enhancer ABC_E1862 Neighboring gene legumain Neighboring gene STARR-positive B cell enhancer ABC_E7170 Neighboring gene STARR-positive B cell enhancer ABC_E3066 Neighboring gene STARR-positive B cell enhancer ABC_E9150 Neighboring gene predicted gene, 30198

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease. Shen R, et al. Transl Neurodegener, 2020 Jun 18. PMID 32552912, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.
      Title: Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of mast cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of negative regulation of mast cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor internalization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of vesicle size IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of vesicle size ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras and Rab interactor 3
    Names
    Ras interaction/interference protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161365.1 → NP_001154837.1  ras and Rab interactor 3 isoform 2

      See identical proteins and their annotated locations for NP_001154837.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and initiates translation at a downstream AUG compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC122302, AC139330
      Consensus CDS
      CCDS49145.1
      UniProtKB/TrEMBL
      Q3U332, Q3U3Y6, Q80WA0
      Related
      ENSMUSP00000122646.2, ENSMUST00000133820.2
      Conserved Domains (3) summary
      pfam02204
      Location:657 → 759
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:808 → 878
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:1 → 73
      SH2; Src homology 2 (SH2) domain

    2. NM_177620.4 → NP_808288.2  ras and Rab interactor 3 isoform 1

      See identical proteins and their annotated locations for NP_808288.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC139330, BC058432, BC137907
      Consensus CDS
      CCDS26118.1
      UniProtKB/Swiss-Prot
      B2RQF8, P59729
      UniProtKB/TrEMBL
      Q3U3Y6
      Related
      ENSMUSP00000060771.8, ENSMUST00000056950.14
      Conserved Domains (3) summary
      cd10395
      Location:52 → 153
      SH2_RIN3; Src homology 2 (SH2) domain found in Ras and Rab interactor 3 (RIN3)-like proteins
      pfam02204
      Location:737 → 839
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:888 → 958
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      102248572..102358982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246670.2 → XP_030102530.1  ras and Rab interactor 3 isoform X2

      Conserved Domains (2) summary
      pfam02204
      Location:406 → 509
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl28922
      Location:544 → 631
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_036157343.1 → XP_036013236.1  ras and Rab interactor 3 isoform X1

    3. XM_030246671.2 → XP_030102531.1  ras and Rab interactor 3 isoform X2

      Conserved Domains (2) summary
      pfam02204
      Location:406 → 509
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl28922
      Location:544 → 631
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59729.2 GenPept UniProtKB/Swiss-Prot:P59729

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