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    Osbpl1a oxysterol binding protein-like 1A [ Mus musculus (house mouse) ]

    Gene ID: 64291, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Osbpl1aprovided by MGI
    Official Full Name
    oxysterol binding protein-like 1Aprovided by MGI
    Primary source
    MGI:MGI:1927551
    See related
    Ensembl:ENSMUSG00000044252 AllianceGenome:MGI:1927551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm753; ORP-1; Osbpl1b; G430090F17Rik
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be involved in lipid transport. Predicted to be located in late endosome and organelle membrane contact site. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; immune system; liver; and retina. Orthologous to human OSBPL1A (oxysterol binding protein like 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 23.6), frontal lobe adult (RPKM 14.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Osbpl1a in Genome Data Viewer
    Location:
    18 A1; 18 6.78 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (12886955..13074933, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12753898..12941871, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene microRNA 1948 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene calcium binding tyrosine phosphorylation regulated Neighboring gene predicted gene, 52343 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:12966807-12966996 Neighboring gene predicted gene, 36439 Neighboring gene STARR-seq mESC enhancer starr_43844 Neighboring gene STARR-seq mESC enhancer starr_43846 Neighboring gene STARR-seq mESC enhancer starr_43847 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9448 Neighboring gene impact, RWD domain protein Neighboring gene histamine receptor H4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sterol binding by OSBP-related protein 1L regulates late endosome motility and function. Vihervaara T, et al. Cell Mol Life Sci, 2011 Feb. PMID 20690035, Free PMC Article
    2. Identification of novel host cell binding partners of Oas1b, the protein conferring resistance to flavivirus-induced disease in mice. Courtney SC, et al. J Virol, 2012 Aug. PMID 22623793, Free PMC Article
    3. Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis. Yan D, et al. Arterioscler Thromb Vasc Biol, 2007 May. PMID 17303778
    4. An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors. Okamura K, et al. DNA Res, 2004 Dec 31. PMID 15871461
    5. An oxysterol-binding protein family identified in the mouse. Anniss AM, et al. DNA Cell Biol, 2002 Aug. PMID 12215260

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in organelle membrane contact site IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 1
    Names
    OSBP-related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252489.1 → NP_001239418.1  oxysterol-binding protein-related protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001239418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a large portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK132676, BC076637, BG092905, BY715608
      Consensus CDS
      CCDS57115.1
      UniProtKB/TrEMBL
      A0A3Q4EI24, Q3V156
      Related
      ENSMUSP00000113914.2, ENSMUST00000119512.8
      Conserved Domains (1) summary
      pfam01237
      Location:156 → 542
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001252490.1 → NP_001239419.1  oxysterol-binding protein-related protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001239419.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a large portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3, 4, 5 and 6 encode the same isoform (3), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      BC076637, BG092905, DV068702
      Consensus CDS
      CCDS57114.1
      UniProtKB/TrEMBL
      Q3UZK3
      Related
      ENSMUSP00000112681.2, ENSMUST00000117361.8
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    3. NM_001252491.2 → NP_001239420.1  oxysterol-binding protein-related protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001239420.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a large portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3, 4, 5 and 6 encode the same isoform (3), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC102055
      Consensus CDS
      CCDS57114.1
      UniProtKB/TrEMBL
      Q3UZK3
      Related
      ENSMUSP00000113735.2, ENSMUST00000118313.8
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    4. NM_001252492.1 → NP_001239421.1  oxysterol-binding protein-related protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001239421.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a large portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3, 4, 5 and 6 encode the same isoform (3), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK168366, BC092247, BG092905, CO044459
      Consensus CDS
      CCDS57114.1
      UniProtKB/TrEMBL
      Q3UZK3
      Related
      ENSMUSP00000113841.2, ENSMUST00000121808.8
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    5. NM_001252493.1 → NP_001239422.1  oxysterol-binding protein-related protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001239422.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and 3' UTR, lacks a large portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3, 4, 5 and 6 encode the same isoform (3), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC102055
      Consensus CDS
      CCDS57114.1
      UniProtKB/TrEMBL
      Q3UZK3
      Related
      ENSMUSP00000112895.2, ENSMUST00000121888.8
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    6. NM_207530.3 → NP_997413.2  oxysterol-binding protein-related protein 1 isoform 1

      See identical proteins and their annotated locations for NP_997413.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC131672, AY536214, BC076637, BG092905
      Consensus CDS
      CCDS29067.1
      UniProtKB/Swiss-Prot
      O88318, Q3TH97, Q673L8, Q6DFU6, Q91XL9
      Related
      ENSMUSP00000073957.5, ENSMUST00000074352.11
      Conserved Domains (5) summary
      COG0666
      Location:38 → 208
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd13285
      Location:229 → 352
      PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
      sd00045
      Location:43 → 78
      ANK; ANK repeat [structural motif]
      pfam01237
      Location:548 → 940
      Oxysterol_BP; Oxysterol-binding protein
      pfam12796
      Location:10 → 111
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. NR_045524.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and lacks a large portion of the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK133806, BB667982, BG092905, BY248497, BY249673, CO426253
      Related
      ENSMUST00000234428.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      12886955..13074933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526144.4 → XP_006526207.1  oxysterol-binding protein-related protein 1 isoform X3

      Conserved Domains (4) summary
      cd13285
      Location:152 → 275
      PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
      sd00045
      Location:43 → 78
      ANK; ANK repeat [structural motif]
      pfam01237
      Location:471 → 863
      Oxysterol_BP; Oxysterol-binding protein
      pfam12796
      Location:10 → 111
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_006526143.4 → XP_006526206.1  oxysterol-binding protein-related protein 1 isoform X2

      Conserved Domains (5) summary
      COG0666
      Location:38 → 208
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:43 → 78
      ANK; ANK repeat [structural motif]
      pfam01237
      Location:507 → 899
      Oxysterol_BP; Oxysterol-binding protein
      pfam12796
      Location:10 → 111
      Ank_2; Ankyrin repeats (3 copies)
      cl17171
      Location:229 → 324
      PH-like; Pleckstrin homology-like domain

    3. XM_006526141.5 → XP_006526204.1  oxysterol-binding protein-related protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006526204.1

      UniProtKB/Swiss-Prot
      O88318, Q3TH97, Q673L8, Q6DFU6, Q91XL9
      Conserved Domains (5) summary
      COG0666
      Location:38 → 208
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd13285
      Location:229 → 352
      PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
      sd00045
      Location:43 → 78
      ANK; ANK repeat [structural motif]
      pfam01237
      Location:548 → 940
      Oxysterol_BP; Oxysterol-binding protein
      pfam12796
      Location:10 → 111
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_036161233.1 → XP_036017126.1  oxysterol-binding protein-related protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q4EI24
      Conserved Domains (1) summary
      pfam01237
      Location:192 → 584
      Oxysterol_BP; Oxysterol-binding protein

    5. XM_030250565.2 → XP_030106425.1  oxysterol-binding protein-related protein 1 isoform X7

      UniProtKB/TrEMBL
      Q3UZK3
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    6. XM_017317960.2 → XP_017173449.1  oxysterol-binding protein-related protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q4EI24
      Conserved Domains (1) summary
      pfam01237
      Location:192 → 584
      Oxysterol_BP; Oxysterol-binding protein

    7. XM_030250567.1 → XP_030106427.1  oxysterol-binding protein-related protein 1 isoform X7

      UniProtKB/TrEMBL
      Q3UZK3
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    8. XM_006526148.3 → XP_006526211.1  oxysterol-binding protein-related protein 1 isoform X7

      See identical proteins and their annotated locations for XP_006526211.1

      UniProtKB/TrEMBL
      Q3UZK3
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    9. XM_017317962.2 → XP_017173451.1  oxysterol-binding protein-related protein 1 isoform X7

      UniProtKB/TrEMBL
      Q3UZK3
      Related
      ENSMUSP00000157342.2, ENSMUST00000234871.2
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    10. XM_017317963.2 → XP_017173452.1  oxysterol-binding protein-related protein 1 isoform X7

      UniProtKB/TrEMBL
      Q3UZK3
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    11. XM_036161236.1 → XP_036017129.1  oxysterol-binding protein-related protein 1 isoform X8

      UniProtKB/TrEMBL
      Q3UZK3
      Conserved Domains (1) summary
      pfam01237
      Location:8 → 400
      Oxysterol_BP; Oxysterol-binding protein

    12. XM_030250568.1 → XP_030106428.1  oxysterol-binding protein-related protein 1 isoform X8

      UniProtKB/TrEMBL
      Q3UZK3
      Related
      ENSMUSP00000113268.2, ENSMUST00000121774.8
      Conserved Domains (1) summary
      pfam01237
      Location:8 → 400
      Oxysterol_BP; Oxysterol-binding protein

    13. XM_036161235.1 → XP_036017128.1  oxysterol-binding protein-related protein 1 isoform X8

      UniProtKB/TrEMBL
      Q3UZK3
      Conserved Domains (1) summary
      pfam01237
      Location:8 → 400
      Oxysterol_BP; Oxysterol-binding protein

    14. XM_017317961.2 → XP_017173450.1  oxysterol-binding protein-related protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A3Q4EI24
      Related
      ENSMUSP00000157209.2, ENSMUST00000235027.2
      Conserved Domains (1) summary
      pfam01237
      Location:156 → 548
      Oxysterol_BP; Oxysterol-binding protein

    15. XM_006526147.3 → XP_006526210.1  oxysterol-binding protein-related protein 1 isoform X7

      See identical proteins and their annotated locations for XP_006526210.1

      UniProtKB/TrEMBL
      Q3UZK3
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    16. XM_030250564.2 → XP_030106424.1  oxysterol-binding protein-related protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A3Q4EG54, A0A3Q4EI24
      Related
      ENSMUSP00000157020.2, ENSMUST00000234118.2
      Conserved Domains (1) summary
      pfam01237
      Location:126 → 518
      Oxysterol_BP; Oxysterol-binding protein

    17. XM_036161237.1 → XP_036017130.1  oxysterol-binding protein-related protein 1 isoform X8

      UniProtKB/TrEMBL
      Q3UZK3
      Conserved Domains (1) summary
      pfam01237
      Location:8 → 400
      Oxysterol_BP; Oxysterol-binding protein

    18. XM_006526142.4 → XP_006526205.1  oxysterol-binding protein-related protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006526205.1

      UniProtKB/Swiss-Prot
      O88318, Q3TH97, Q673L8, Q6DFU6, Q91XL9
      Conserved Domains (5) summary
      COG0666
      Location:38 → 208
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd13285
      Location:229 → 352
      PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
      sd00045
      Location:43 → 78
      ANK; ANK repeat [structural motif]
      pfam01237
      Location:548 → 940
      Oxysterol_BP; Oxysterol-binding protein
      pfam12796
      Location:10 → 111
      Ank_2; Ankyrin repeats (3 copies)

    19. XM_030250566.2 → XP_030106426.1  oxysterol-binding protein-related protein 1 isoform X7

      UniProtKB/TrEMBL
      Q3UZK3
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    20. XM_017317965.1 → XP_017173454.1  oxysterol-binding protein-related protein 1 isoform X7

      UniProtKB/TrEMBL
      Q3UZK3
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    21. XM_036161238.1 → XP_036017131.1  oxysterol-binding protein-related protein 1 isoform X8

      UniProtKB/TrEMBL
      Q3UZK3
      Conserved Domains (1) summary
      pfam01237
      Location:8 → 400
      Oxysterol_BP; Oxysterol-binding protein

    22. XM_017317964.1 → XP_017173453.1  oxysterol-binding protein-related protein 1 isoform X7

      UniProtKB/TrEMBL
      Q3UZK3
      Conserved Domains (1) summary
      pfam01237
      Location:35 → 427
      Oxysterol_BP; Oxysterol-binding protein

    RNA

    1. XR_004939876.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_020573.1: Suppressed sequence

      Description
      NM_020573.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XL9.2 GenPept UniProtKB/Swiss-Prot:Q91XL9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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