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    fkh-7 Fork-head domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177340, updated on 2-Nov-2024

    Summary

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    Official Symbol
    fkh-7
    Official Full Name
    Fork-head domain-containing protein
    Primary source
    WormBase:WBGene00001439
    Locus tag
    CELE_F26D12.1
    See related
    AllianceGenome:WB:WBGene00001439
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including intestine; neurons; pharynx; reproductive system; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; autism spectrum disorder (multiple); autoimmune disease (multiple); communication disorder (multiple); and gastrointestinal system cancer (multiple). Orthologous to several human genes including FOXP2 (forkhead box P2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See fkh-7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (5584684..5610378)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The forkhead gene family of Caenorhabditis elegans. Hope IA, et al. Gene, 2003 Jan 30. PMID 12568714
    2. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Panowski SH, et al. Nature, 2007 May 31. PMID 17476212
    3. The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine. McGhee JD, et al. Dev Biol, 2007 Feb 15. PMID 17113066
    4. The regulatory content of intergenic DNA shapes genome architecture. Nelson CE, et al. Genome Biol, 2004. PMID 15059258, Free PMC Article
    5. Individual cell types in C. elegans age differently and activate distinct cell-protective responses. Roux AE, et al. Cell Rep, 2023 Aug 29. PMID 37531250

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fork-head domain-containing protein
    NP_001023147.1
    • Partially confirmed by transcript evidence
    NP_001023148.1
    • Partially confirmed by transcript evidence
    NP_001293720.1
    • Confirmed by transcript evidence
    NP_001293721.1
    • Confirmed by transcript evidence
    NP_001293723.1
    • Confirmed by transcript evidence
    NP_001293724.1
    • Confirmed by transcript evidence
    NP_001293811.1
    • Partially confirmed by transcript evidence
    NP_001293812.1
    • Partially confirmed by transcript evidence
    NP_001293813.1
    • Confirmed by transcript evidence
    NP_001293814.1
    • Confirmed by transcript evidence
    NP_001293815.1
    • Confirmed by transcript evidence
    NP_001293816.1
    • Confirmed by transcript evidence
    NP_001368377.1
    • Confirmed by transcript evidence
    NP_001368378.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5584684..5610378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306884.4 → NP_001293813.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293813.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLS2
      Conserved Domains (2) summary
      cd20065
      Location:562 → 644
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
      pfam16159
      Location:326 → 393
      FOXP-CC; FOXP coiled-coil domain

    2. NM_001306882.4 → NP_001293811.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293811.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLX2
      Conserved Domains (2) summary
      cd20065
      Location:562 → 644
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
      pfam16159
      Location:326 → 393
      FOXP-CC; FOXP coiled-coil domain

    3. NM_001027976.7 → NP_001023147.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023147.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86MF0
      Conserved Domains (3) summary
      COG5025
      Location:515 → 676
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd00059
      Location:563 → 636
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16159
      Location:326 → 393
      FOXP-CC; FOXP coiled-coil domain

    4. NM_001306885.3 → NP_001293814.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293814.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CJE7
      Conserved Domains (2) summary
      cd20065
      Location:562 → 644
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
      pfam16159
      Location:326 → 393
      FOXP-CC; FOXP coiled-coil domain

    5. NM_001027977.5 → NP_001023148.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023148.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86ME9
      Conserved Domains (3) summary
      COG5025
      Location:329 → 490
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd00059
      Location:377 → 450
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16159
      Location:140 → 207
      FOXP-CC; FOXP coiled-coil domain

    6. NM_001306883.3 → NP_001293812.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLW4
      Conserved Domains (2) summary
      cd20065
      Location:376 → 458
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
      pfam16159
      Location:140 → 207
      FOXP-CC; FOXP coiled-coil domain

    7. NM_001306886.3 → NP_001293815.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293815.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CKK8
      Conserved Domains (2) summary
      cd20065
      Location:376 → 458
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
      pfam16159
      Location:140 → 207
      FOXP-CC; FOXP coiled-coil domain

    8. NM_001306887.3 → NP_001293816.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293816.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLX8
      Conserved Domains (2) summary
      cd20065
      Location:376 → 458
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
      pfam16159
      Location:140 → 207
      FOXP-CC; FOXP coiled-coil domain

    9. NM_001306791.3 → NP_001293720.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293720.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CIY1
      Conserved Domains (2) summary
      COG5025
      Location:32 → 284
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd20065
      Location:79 → 161
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    10. NM_001380234.1 → NP_001368377.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLH2
      Conserved Domains (1) summary
      cd20065
      Location:79 → 161
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    11. NM_001306794.3 → NP_001293723.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293723.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLF5
      Conserved Domains (1) summary
      cd20065
      Location:79 → 161
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    12. NM_001306795.3 → NP_001293724.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293724.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLC1
      Conserved Domains (1) summary
      cd20065
      Location:79 → 161
      FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

    13. NM_001306792.3 → NP_001293721.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293721.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CK27

    14. NM_001380235.1 → NP_001368378.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CIY6

    RNA

    1. NR_131492.1 RNA Sequence

      Status: REVIEWED

    2. NR_131493.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
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