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    Dcn decorin [ Mus musculus (house mouse) ]

    Gene ID: 13179, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dcnprovided by MGI
    Official Full Name
    decorinprovided by MGI
    Primary source
    MGI:MGI:94872
    See related
    Ensembl:ENSMUSG00000019929 AllianceGenome:MGI:94872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DC; PG40; PGII; PGS2; DSPG2; SLRR1B
    Summary
    This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in bladder adult (RPKM 1095.0), subcutaneous fat pad adult (RPKM 305.9) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dcn in Genome Data Viewer
    Location:
    10 C3; 10 50.27 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (97315362..97354025)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (97479500..97518163)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CWC15 homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8867 Neighboring gene STARR-seq mESC enhancer starr_27689 Neighboring gene STARR-positive B cell enhancer ABC_E6912 Neighboring gene predicted gene, 34114 Neighboring gene microRNA 3966 Neighboring gene STARR-seq mESC enhancer starr_27690 Neighboring gene STARR-seq mESC enhancer starr_27691 Neighboring gene RIKEN cDNA 4930473O22 gene Neighboring gene lumican

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Decorin modulates collagen matrix assembly and mineralization. Mochida Y, et al. Matrix Biol, 2009 Jan. PMID 19049867, Free PMC Article
    2. Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. Bi X, et al. Carcinogenesis, 2008 Jul. PMID 18550571, Free PMC Article
    3. Decorin deficiency promotes hepatic carcinogenesis. Horváth Z, et al. Matrix Biol, 2014 Apr. PMID 24361483, Free PMC Article
    4. Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction. Schaefer L, et al. Am J Pathol, 2002 Mar. PMID 11891213, Free PMC Article
    5. Pathophysiological mechanisms of autosomal dominant congenital stromal corneal dystrophy: C-terminal-truncated decorin results in abnormal matrix assembly and altered expression of small leucine-rich proteoglycans. Chen S, et al. Am J Pathol, 2011 Nov. PMID 21893019, Free PMC Article

    See all (231) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decorin in the spatial control of collagen mineralization.
      Title: Decorin in the spatial control of collagen mineralization.
    2. A role for decorin in improving motor deficits after traumatic brain injury.
      Title: A role for decorin in improving motor deficits after traumatic brain injury.
    3. Neonatal Achilles Tendon Microstructure is Negatively Impacted by Decorin and Biglycan Knockdown After Injury and During Development.
      Title: Neonatal Achilles Tendon Microstructure is Negatively Impacted by Decorin and Biglycan Knockdown After Injury and During Development.
    4. Investigating the temporal roles of decorin and biglycan in tendon healing.
      Title: Investigating the temporal roles of decorin and biglycan in tendon healing.
    5. The aberrant levels of decorin induce damages of human salivary gland epithelial cells and polarization of macrophages.
      Title: The aberrant levels of decorin induce damages of human salivary gland epithelial cells and polarization of macrophages.
    6. [Effect of up-regulation of Decorin on expression of EGFR, C-Myc and p21 in nude mice with oral squamous cell carcinoma].
      Title: [Effect of up-regulation of Decorin on expression of EGFR, C-Myc and p21 in nude mice with oral squamous cell carcinoma].
    7. Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
      Title: Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
    8. Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Abeta amyloidosis.
      Title: Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis.
    9. Decorin Induces Cardiac Hypertrophy by Regulating the CaMKII/MEF-2 Signaling Pathway In Vivo.
      Title: Decorin Induces Cardiac Hypertrophy by Regulating the CaMKII/MEF-2 Signaling Pathway In Vivo.
    10. Transcriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birthdagger.
      Title: Transcriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birth†.
    Submit: New GeneRIF Correction See all GeneRIFs (92)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellular matrix structural constituent conferring compression resistance RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables glycosaminoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of collagen type VI trimer ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    decorin
    Names
    bone proteoglycan II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190451.2 → NP_001177380.1  decorin preproprotein

      See identical proteins and their annotated locations for NP_001177380.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC159710, AK145905, BG088078, BM114383
      Consensus CDS
      CCDS24141.1
      UniProtKB/Swiss-Prot
      P28654
      UniProtKB/TrEMBL
      Q3TSV1, Q3UKR1
      Related
      ENSMUSP00000100924.4, ENSMUST00000105287.11
      Conserved Domains (4) summary
      smart00013
      Location:48 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:79 → 285
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:57 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:79 → 136
      LRR_8; Leucine rich repeat

    2. NM_007833.6 → NP_031859.1  decorin preproprotein

      See identical proteins and their annotated locations for NP_031859.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA881173, AC159710, BB575065, BM114383, CK623125, DV056002, W62675
      Consensus CDS
      CCDS24141.1
      UniProtKB/Swiss-Prot
      P28654
      UniProtKB/TrEMBL
      Q3TSV1, Q3UKR1
      Related
      ENSMUSP00000131431.3, ENSMUST00000163448.4
      Conserved Domains (4) summary
      smart00013
      Location:48 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:79 → 285
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:57 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:79 → 136
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      97315362..97354025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28654.1 GenPept UniProtKB/Swiss-Prot:P28654

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