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    Tsn translin [ Mus musculus (house mouse) ]

    Gene ID: 22099, updated on 28-Oct-2024

    Summary

    Official Symbol
    Tsnprovided by MGI
    Official Full Name
    translinprovided by MGI
    Primary source
    MGI:MGI:109263
    See related
    Ensembl:ENSMUSG00000026374 AllianceGenome:MGI:109263
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C3PO; TB-RBP; 2610034C24Rik
    Summary
    Enables mRNA binding activity. Predicted to be involved in siRNA processing. Located in cytoplasm and male germ cell nucleus. Orthologous to human TSN (translin). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 26.5), CNS E14 (RPKM 24.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tsn in Genome Data Viewer
    Location:
    1 E2.3; 1 52.14 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (118226244..118239463, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (118298514..118311461, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene retinoblastoma binding protein 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01974 Neighboring gene predicted gene, 53580 Neighboring gene STARR-seq mESC enhancer starr_01975 Neighboring gene STARR-positive B cell enhancer ABC_E5790 Neighboring gene nucleolar protein interacting with the FHA domain of MKI67 Neighboring gene predicted gene 28867

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in siRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    part_of endoribonuclease complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    translin
    Names
    component 3 of promoter of RISC
    testis/brain-RNA-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011650.4NP_035780.1  translin

      See identical proteins and their annotated locations for NP_035780.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer, protein-coding variant.
      Source sequence(s)
      AC121531, CX243508
      Consensus CDS
      CCDS35690.1
      UniProtKB/Swiss-Prot
      Q62348
      UniProtKB/TrEMBL
      Q545E6
      Related
      ENSMUSP00000027623.8, ENSMUST00000027623.9
      Conserved Domains (1) summary
      cd14819
      Location:10216
      Translin; also known as TB-RBP (testis brain RNA-binding protein)

    RNA

    1. NR_153836.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' end compared to variant 1. This variant is represented as non-coding because it lacks the translational start codon and a believable ORF, compared to variant 1.
      Source sequence(s)
      AC121531

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      118226244..118239463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252998.2XP_030108858.1  translin isoform X1

      Conserved Domains (1) summary
      cl00957
      Location:10126
      Translin-like; Translin and translin-associated factor-X (TRAX)