FYN FYN proto-oncogene, Src family tyrosine kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: FYNprovided by HGNC
Official Full Name: FYN proto-oncogene, Src family tyrosine kinaseprovided by HGNC
Primary source: HGNC:HGNC:4037
See related: Ensembl:ENSG00000010810 MIM:137025; AllianceGenome:HGNC:4037
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SLK; SYN; p59-FYN
Summary: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
Expression: Broad expression in brain (RPKM 36.8), lymph node (RPKM 29.8) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q21

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (111660332..111873452, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (112843350..113056537, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (111981535..112194655, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FYN as an emerging biological biomarker for prognosis and potential therapeutic target in LGG.
Title: FYN as an emerging biological biomarker for prognosis and potential therapeutic target in LGG.
YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway.
Title: YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway.
Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.
Title: Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.
Advances in the expression and function of Fyn in different human tumors.
Title: Advances in the expression and function of Fyn in different human tumors.
Role of Fyn in hematological malignancies.
Title: Role of Fyn in hematological malignancies.
The Interrelationship Between FYN and miR-128/193a-5p/494 in Imatinib Resistance in Prostate Cancer.
Title: The Interrelationship Between FYN and miR-128/193a-5p/494 in Imatinib Resistance in Prostate Cancer.
FYN: emerging biological roles and potential therapeutic targets in cancer.
Title: FYN: emerging biological roles and potential therapeutic targets in cancer.
Highly expressed FYN promotes the progression of placenta accreta by activating STAT3, p38, and JNK signaling pathways.
Title: Highly expressed FYN promotes the progression of placenta accreta by activating STAT3, p38, and JNK signaling pathways.
Fyn and Lyn gene polymorphisms impact the risk of thyroid cancer.
Title: Fyn and Lyn gene polymorphisms impact the risk of thyroid cancer.
Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling.
Title: Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling.

Submit: New GeneRIF Correction See all GeneRIFs (185)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of proneness to anger. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tyrosine kinase Fyn-mediated phosphorylation of IFITM3 at position Y20 induces localization of IFITM3 at the endocytic compartments, which impairs inhibition of Env-mediated entry by IFITM3 delta(1-21) mutant	PubMed
	env	Interaction of HIV-1 gp120 with CD4 leads to increased levels of phosphorylation of the src-family Lck and Fyn protein tyrosine kinases and enhancement of their activities	PubMed
Envelope surface glycoprotein gp160, precursor	env	Pretreatment of cells with HIV-1 gp160 results in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp120 and gp41-induced cell killing is accompanied by tyrosine phosphorylation and activation of the CD4-associated p56(Lck) kinase, and by activation of a second member of the scr family of protein tyrosine kinases, p59(fyn) kinase	PubMed
Nef	nef	HIV-1 Nef binds to the SH3 domain of Fyn through its proline-rich (PXXP) motifs between amino acid residues 65 and 82; this binding enhances viral replication but not down-regulation of CD4	PubMed
	nef	The single amino acid residue number 96 in the SH3 domain of Fyn regulates its affinity and specificity in binding to HIV-1 Nef	PubMed
	nef	Crystal structure studies reveal the conserved PXXP sequence motif of HIV-1 Nef is part of a polyproline type II helix that is required for Nef binding to the SH3 domain of Fyn	PubMed
Pr55(Gag)	gag	Fyn enhances HIV-1 Gag assembly and release in T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

FYN_1578 (e-PCR)
- UniSTS:277262

G20422 (e-PCR)
- UniSTS:9280

A005Q39 (e-PCR)
- UniSTS:9281

SHGC-960 (e-PCR)
- UniSTS:22607

SHGC-78694 (e-PCR)
- UniSTS:95577

AL022469 (e-PCR)
- UniSTS:47230

D6S2035 (e-PCR)
- UniSTS:80260

RH76192 (e-PCR)
- UniSTS:91273

GDB:187104 (e-PCR)
- UniSTS:155538

RH46682 (e-PCR)
- UniSTS:75426

SHGC-31232 (e-PCR)
- UniSTS:75427

SHGC-30883 (e-PCR)
- UniSTS:68519

D6S302 (e-PCR)
- UniSTS:77735

AL023485 (e-PCR)
- UniSTS:72113

STS-N35086 (e-PCR)
- UniSTS:5300

RH46768 (e-PCR)
- UniSTS:10972

RH48180 (e-PCR)
- UniSTS:3551

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables alpha-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables disordered domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables phospholipase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables tau protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables tau protein binding	NAS Non-traceable Author Statement more info	PubMed
enables tau protein binding	TAS Traceable Author Statement more info	PubMed
enables tau-protein kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables type 5 metabotropic glutamate receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis	TAS Traceable Author Statement more info
involved_in G protein-coupled glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell costimulation	TAS Traceable Author Statement more info
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in activated T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	TAS Traceable Author Statement more info
involved_in calcium ion transport	NAS Non-traceable Author Statement more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to L-glutamate	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to amyloid-beta	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glycine	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in dendritic spine maintenance	TAS Traceable Author Statement more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	TAS Traceable Author Statement more info
involved_in feeding behavior	TAS Traceable Author Statement more info	PubMed
involved_in forebrain development	IEA Inferred from Electronic Annotation more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in heart process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in learning	TAS Traceable Author Statement more info	PubMed
involved_in leukocyte migration	TAS Traceable Author Statement more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendritic spine maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hydrogen peroxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of inflammatory response to antigenic stimulus	TAS Traceable Author Statement more info
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to membrane	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info
involved_in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	NAS Non-traceable Author Statement more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in reelin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of calcium ion import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to amyloid-beta	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to singlet oxygen	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in stimulatory C-type lectin receptor signaling pathway	TAS Traceable Author Statement more info
involved_in vascular endothelial growth factor receptor signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in glial cell projection	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perinuclear endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tyrosine-protein kinase Fyn

Names: FYN oncogene related to SRC, FGR, YES; OKT3-induced calcium influx regulator; c-syn protooncogene; proto-oncogene Syn; proto-oncogene c-Fyn; src-like kinase; src/yes-related novel; tyrosine kinase p59fyn(T)

NP_001357458.1

EC 2.7.10.2

NP_002028.1

EC 2.7.10.2

NP_694592.1

EC 2.7.10.2

NP_694593.1

EC 2.7.10.2

XP_005266949.1

EC 2.7.10.2

XP_016866139.1

EC 2.7.10.2

XP_016866140.1

EC 2.7.10.2

XP_016866141.1

EC 2.7.10.2

XP_016866142.1

EC 2.7.10.2

XP_047274517.1

EC 2.7.10.2

XP_047274518.1

EC 2.7.10.2

XP_047274519.1

EC 2.7.10.2

XP_047274521.1

EC 2.7.10.2

XP_047274522.1

EC 2.7.10.2

XP_047274523.1

EC 2.7.10.2

XP_047274524.1

EC 2.7.10.2

XP_047274525.1

EC 2.7.10.2

XP_047274526.1

EC 2.7.10.2

XP_047274527.1

EC 2.7.10.2

XP_047274528.1

EC 2.7.10.2

XP_047274529.1

EC 2.7.10.2

XP_054210977.1

EC 2.7.10.2

XP_054210978.1

EC 2.7.10.2

XP_054210979.1

EC 2.7.10.2

XP_054210980.1

EC 2.7.10.2

XP_054210981.1

EC 2.7.10.2

XP_054210982.1

EC 2.7.10.2

XP_054210983.1

EC 2.7.10.2

XP_054210984.1

EC 2.7.10.2

XP_054210985.1

EC 2.7.10.2

XP_054210986.1

EC 2.7.10.2

XP_054210987.1

EC 2.7.10.2

XP_054210988.1

EC 2.7.10.2

XP_054210989.1

EC 2.7.10.2

XP_054210990.1

EC 2.7.10.2

XP_054210991.1

EC 2.7.10.2

XP_054210992.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370529.1 → NP_001357458.1 tyrosine-protein kinase Fyn isoform a

Status: REVIEWED

Source sequence(s)

AL109916, Z97989

Consensus CDS

CCDS5094.1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7

UniProtKB/TrEMBL

B3KPS6

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
NM_002037.5 → NP_002028.1 tyrosine-protein kinase Fyn isoform a

See identical proteins and their annotated locations for NP_002028.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

BP391373, DA570412, M14333, Z97989

Consensus CDS

CCDS5094.1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7

UniProtKB/TrEMBL

B3KPS6

Related

ENSP00000346671.3, ENST00000354650.7

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
NM_153047.4 → NP_694592.1 tyrosine-protein kinase Fyn isoform b

See identical proteins and their annotated locations for NP_694592.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, and lacks an alternate in-frame exon but includes a different in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AL109916, AL158035, Z97989

Consensus CDS

CCDS5095.1

UniProtKB/TrEMBL

B3KPS6

Related

ENSP00000357671.3, ENST00000368682.8

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:258 → 531

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
NM_153048.4 → NP_694593.1 tyrosine-protein kinase Fyn isoform c

See identical proteins and their annotated locations for NP_694593.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.

Source sequence(s)

BC032496, BP391373, Z97989

Consensus CDS

CCDS5096.1

UniProtKB/TrEMBL

B3KPS6

Related

ENSP00000229471.4, ENST00000229471.8

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cl21453
Location:231 → 467

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

111660332..111873452 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047418569.1 → XP_047274525.1 tyrosine-protein kinase Fyn isoform X2

Related

ENSP00000357667.4, ENST00000368678.8
XM_047418561.1 → XP_047274517.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_005266892.5 → XP_005266949.1 tyrosine-protein kinase Fyn isoform X3

See identical proteins and their annotated locations for XP_005266949.1

UniProtKB/TrEMBL

B3KPS6

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cl21453
Location:231 → 467

PKc_like; Protein Kinases, catalytic domain
XM_047418570.1 → XP_047274526.1 tyrosine-protein kinase Fyn isoform X2
XM_017010651.2 → XP_016866140.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7

UniProtKB/TrEMBL

B3KPS6

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_047418562.1 → XP_047274518.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_047418566.1 → XP_047274522.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_047418572.1 → XP_047274528.1 tyrosine-protein kinase Fyn isoform X3
XM_047418568.1 → XP_047274524.1 tyrosine-protein kinase Fyn isoform X2
XM_017010650.2 → XP_016866139.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7

UniProtKB/TrEMBL

B3KPS6

Related

ENSP00000357656.2, ENST00000368667.6

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_017010652.2 → XP_016866141.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7

UniProtKB/TrEMBL

B3KPS6

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_017010653.2 → XP_016866142.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7

UniProtKB/TrEMBL

B3KPS6

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_047418571.1 → XP_047274527.1 tyrosine-protein kinase Fyn isoform X2
XM_047418565.1 → XP_047274521.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_047418567.1 → XP_047274523.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_047418563.1 → XP_047274519.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_047418573.1 → XP_047274529.1 tyrosine-protein kinase Fyn isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

112843350..113056537 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054355012.1 → XP_054210987.1 tyrosine-protein kinase Fyn isoform X2
XM_054355003.1 → XP_054210978.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_054355015.1 → XP_054210990.1 tyrosine-protein kinase Fyn isoform X3
XM_054355013.1 → XP_054210988.1 tyrosine-protein kinase Fyn isoform X2
XM_054355006.1 → XP_054210981.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_054355004.1 → XP_054210979.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_054355010.1 → XP_054210985.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_054355002.1 → XP_054210977.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_054355016.1 → XP_054210991.1 tyrosine-protein kinase Fyn isoform X3
XM_054355011.1 → XP_054210986.1 tyrosine-protein kinase Fyn isoform X2
XM_054355007.1 → XP_054210982.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_054355009.1 → XP_054210984.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_054355005.1 → XP_054210980.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_054355008.1 → XP_054210983.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/Swiss-Prot

B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
XM_054355014.1 → XP_054210989.1 tyrosine-protein kinase Fyn isoform X2
XM_054355017.1 → XP_054210992.1 tyrosine-protein kinase Fyn isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001242779.1: Suppressed sequence

Description

NM_001242779.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.