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    RAPGEF1 Rap guanine nucleotide exchange factor 1 [ Homo sapiens (human) ]

    Gene ID: 2889, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RAPGEF1provided by HGNC
    Official Full Name
    Rap guanine nucleotide exchange factor 1provided by HGNC
    Primary source
    HGNC:HGNC:4568
    See related
    Ensembl:ENSG00000107263 MIM:600303; AllianceGenome:HGNC:4568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C3G; GRF2
    Summary
    This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 13.7), lymph node (RPKM 12.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RAPGEF1 in Genome Data Viewer
    Location:
    9q34.13
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (131576775..131740076, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (143789743..143952984, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (134452162..134615463, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:134403902-134405101 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134405807-134406720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20421 Neighboring gene NANOG hESC enhancer GRCh37_chr9:134426802-134427303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134443475-134443974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29193 Neighboring gene uridine-cytidine kinase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134464737-134465236 Neighboring gene proline rich transmembrane protein 1B Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:134481176-134481676 Neighboring gene Sharpr-MPRA regulatory region 10461 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134493979-134494945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134499860-134500360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29197 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134504170-134504919 Neighboring gene Sharpr-MPRA regulatory region 12258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134530670-134531170 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134534752-134535285 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134535286-134535818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29207 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:134558729-134559329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29208 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:134584807-134585588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134587455-134587956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134587957-134588456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134598083-134598582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29212 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20422 Neighboring gene Sharpr-MPRA regulatory region 1247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29213 Neighboring gene Sharpr-MPRA regulatory region 10210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29214 Neighboring gene RNA, 7SL, cytoplasmic 328, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134630482-134631089 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134669412-134669916 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:134674709-134674899 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134680399-134680898 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134682767-134683702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134689077-134689577 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134692257-134692758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134703449-134703948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134713047-134713585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134730057-134731006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134731007-134731954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134752115-134752615 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134764767-134765298 Neighboring gene Sharpr-MPRA regulatory region 801 Neighboring gene mediator complex subunit 27 Neighboring gene NANOG hESC enhancer GRCh37_chr9:134840462-134840963 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:134843516-134843723 Neighboring gene MPRA-validated peak7336 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:134882251-134882943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134915689-134916190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134916191-134916690 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:134917173-134918372 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:134951028-134952227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29216

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton. Radha V, et al. BMC Cell Biol, 2004 Aug 20. PMID 15320955, Free PMC Article
    2. C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation. Ortiz-Rivero S, et al. Cell Commun Signal, 2018 Dec 19. PMID 30567575, Free PMC Article
    3. Cytoskeletal remodeling by C3G to induce neurite-like extensions and inhibit motility in highly invasive breast carcinoma cells. Dayma K, et al. Biochim Biophys Acta, 2011 Mar. PMID 21223981
    4. Inactivation of Crk SH3 domain-binding guanine nucleotide-releasing factor (C3G) in cervical squamous cell carcinoma. Okino K, et al. Int J Gynecol Cancer, 2006 Mar-Apr. PMID 16681758
    5. Transformation suppressor activity of C3G is independent of its CDC25-homology domain. Guerrero C, et al. Oncogene, 1998 Feb 5. PMID 9482107

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and functional validation of SRC and RAPGEF1 as new direct targets of miR-203, involved in regulation of epidermal homeostasis.
      Title: Identification and functional validation of SRC and RAPGEF1 as new direct targets of miR-203, involved in regulation of epidermal homeostasis.
    2. Experimental Characterization of the Interaction between the N-Terminal SH3 Domain of Crkl and C3G.
      Title: Experimental Characterization of the Interaction between the N-Terminal SH3 Domain of Crkl and C3G.
    3. Zebrafish modeling mimics developmental phenotype of patients with RAPGEF1 mutation.
      Title: Zebrafish modeling mimics developmental phenotype of patients with RAPGEF1 mutation.
    4. Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas.
      Title: Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas.
    5. Complex formation and reciprocal regulation between GSK3beta and C3G.
      Title: Complex formation and reciprocal regulation between GSK3β and C3G.
    6. C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length.
      Title: C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length.
    7. C3G plays a significant role in different steps of megakaryopoiesis
      Title: C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation.
    8. our studies uncover novel mechanisms by which C3G controls key aspects of tumorigenesis.
      Title: C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms.
    9. C3G/RAP1 activity is involved in the metastatic spread of epithelial ovarian cancer.
      Title: The C3G/Rap1 pathway promotes secretion of MMP-2 and MMP-9 and is involved in serous ovarian cancer metastasis.
    10. C3G plays an important role in platelet clotting through a mechanism involving its GEF activity and suggest that it might be also involved in neutrophil development.
      Title: C3G transgenic mouse models with specific expression in platelets reveal a new role for C3G in platelet clotting through its GEF activity.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of Rap guanine nucleotide exchange factor 1 (RAPGEF1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp781P1719

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rap protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to cAMP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to nerve growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in establishment of endothelial barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nerve growth factor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rap guanine nucleotide exchange factor 1
    Names
    CRK SH3-binding GNRP
    Rap guanine nucleotide exchange factor (GEF) 1
    guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050622.2 RefSeqGene

      Range
      5000..168301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001304275.2 → NP_001291204.1  rap guanine nucleotide exchange factor 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL160271, AL160276
      Consensus CDS
      CCDS78450.1
      UniProtKB/Swiss-Prot
      Q13905
      Related
      ENSP00000361269.1, ENST00000372195.5
      Conserved Domains (2) summary
      smart00147
      Location:853 → 1082
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:705 → 846
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    2. NM_001377935.1 → NP_001364864.1  rap guanine nucleotide exchange factor 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL160271, AL160276
      Consensus CDS
      CCDS94521.1
      UniProtKB/TrEMBL
      A0A804HL87
      Related
      ENSP00000508246.1, ENST00000683357.1
      Conserved Domains (3) summary
      smart00147
      Location:1022 → 1251
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:874 → 1015
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:227 → 824
      PHA03247; large tegument protein UL36; Provisional

    3. NM_001377936.1 → NP_001364865.1  rap guanine nucleotide exchange factor 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL160276
      UniProtKB/TrEMBL
      A0A1S5UYZ7
      Conserved Domains (3) summary
      smart00147
      Location:835 → 1064
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:687 → 828
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:179 → 437
      PHA03247; large tegument protein UL36; Provisional

    4. NM_001377937.1 → NP_001364866.1  rap guanine nucleotide exchange factor 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL160271, AL160276
      Conserved Domains (3) summary
      smart00147
      Location:815 → 1044
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:667 → 808
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:190 → 448
      PHA03247; large tegument protein UL36; Provisional

    5. NM_001377938.1 → NP_001364867.1  rap guanine nucleotide exchange factor 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL160271, AL160276
      Conserved Domains (4) summary
      smart00147
      Location:985 → 1214
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:837 → 978
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:190 → 448
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:675 → 846
      PHA03307; transcriptional regulator ICP4; Provisional

    6. NM_005312.4 → NP_005303.2  rap guanine nucleotide exchange factor 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL160271, AL160276
      Consensus CDS
      CCDS48047.1
      UniProtKB/Swiss-Prot
      Q13905, Q5JUE4, Q68DL3, Q8IV73
      Related
      ENSP00000361263.2, ENST00000372189.7
      Conserved Domains (2) summary
      smart00147
      Location:836 → 1065
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:688 → 829
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    7. NM_198679.2 → NP_941372.1  rap guanine nucleotide exchange factor 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL160271, AL160276
      Consensus CDS
      CCDS48048.1
      UniProtKB/Swiss-Prot
      Q13905
      Related
      ENSP00000361264.3, ENST00000372190.8
      Conserved Domains (2) summary
      smart00147
      Location:854 → 1083
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:706 → 847
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      131576775..131740076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272186.5 → XP_005272243.1  rap guanine nucleotide exchange factor 1 isoform X4

      Conserved Domains (4) summary
      smart00147
      Location:1023 → 1252
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:875 → 1016
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:228 → 486
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:713 → 884
      PHA03307; transcriptional regulator ICP4; Provisional

    2. XM_011518572.3 → XP_011516874.1  rap guanine nucleotide exchange factor 1 isoform X2

      Conserved Domains (2) summary
      smart00147
      Location:1031 → 1260
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:883 → 1024
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    3. XM_047423252.1 → XP_047279208.1  rap guanine nucleotide exchange factor 1 isoform X10

      Related
      ENST00000419442.2

    4. XM_017014633.2 → XP_016870122.1  rap guanine nucleotide exchange factor 1 isoform X5

    5. XM_047423251.1 → XP_047279207.1  rap guanine nucleotide exchange factor 1 isoform X9

    6. XM_011518571.3 → XP_011516873.1  rap guanine nucleotide exchange factor 1 isoform X1

      Conserved Domains (2) summary
      smart00147
      Location:1032 → 1261
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:884 → 1025
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    7. XM_047423254.1 → XP_047279210.1  rap guanine nucleotide exchange factor 1 isoform X18

    8. XM_024447521.2 → XP_024303289.1  rap guanine nucleotide exchange factor 1 isoform X17

      Conserved Domains (3) summary
      smart00147
      Location:852 → 1081
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:704 → 845
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cl26464
      Location:196 → 454
      Atrophin-1; Atrophin-1 family

    9. XM_006717072.4 → XP_006717135.1  rap guanine nucleotide exchange factor 1 isoform X8

      Conserved Domains (2) summary
      smart00147
      Location:991 → 1220
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:843 → 984
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    10. XM_006717074.4 → XP_006717137.1  rap guanine nucleotide exchange factor 1 isoform X16

      Conserved Domains (2) summary
      smart00147
      Location:859 → 1088
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:711 → 852
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    11. XM_047423253.1 → XP_047279209.1  rap guanine nucleotide exchange factor 1 isoform X14

    12. XM_006717067.4 → XP_006717130.1  rap guanine nucleotide exchange factor 1 isoform X3

      Conserved Domains (2) summary
      smart00147
      Location:1029 → 1258
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:881 → 1022
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    13. XM_011518579.4 → XP_011516881.1  rap guanine nucleotide exchange factor 1 isoform X15

      Conserved Domains (2) summary
      smart00147
      Location:867 → 1096
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:719 → 860
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    14. XM_011518578.4 → XP_011516880.1  rap guanine nucleotide exchange factor 1 isoform X13

      Conserved Domains (2) summary
      smart00147
      Location:898 → 1127
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:750 → 891
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    15. XM_011518577.4 → XP_011516879.1  rap guanine nucleotide exchange factor 1 isoform X12

      Conserved Domains (2) summary
      smart00147
      Location:919 → 1148
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:771 → 912
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    16. XM_011518576.4 → XP_011516878.1  rap guanine nucleotide exchange factor 1 isoform X11

      Conserved Domains (2) summary
      smart00147
      Location:920 → 1149
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:772 → 913
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    17. XM_017014636.3 → XP_016870125.1  rap guanine nucleotide exchange factor 1 isoform X7

    18. XM_017014635.3 → XP_016870124.1  rap guanine nucleotide exchange factor 1 isoform X6

    19. XM_011518581.4 → XP_011516883.1  rap guanine nucleotide exchange factor 1 isoform X19

      Conserved Domains (1) summary
      PHA03247
      Location:242 → 500
      PHA03247; large tegument protein UL36; Provisional

    20. XM_047423255.1 → XP_047279211.1  rap guanine nucleotide exchange factor 1 isoform X21

    21. XM_011518582.4 → XP_011516884.1  rap guanine nucleotide exchange factor 1 isoform X20

      Conserved Domains (1) summary
      PHA03247
      Location:242 → 500
      PHA03247; large tegument protein UL36; Provisional

    22. XM_047423256.1 → XP_047279212.1  rap guanine nucleotide exchange factor 1 isoform X22

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      143789743..143952984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362783.1 → XP_054218758.1  rap guanine nucleotide exchange factor 1 isoform X4

    2. XM_054362781.1 → XP_054218756.1  rap guanine nucleotide exchange factor 1 isoform X2

    3. XM_054362788.1 → XP_054218763.1  rap guanine nucleotide exchange factor 1 isoform X10

    4. XM_054362784.1 → XP_054218759.1  rap guanine nucleotide exchange factor 1 isoform X5

    5. XM_054362787.1 → XP_054218762.1  rap guanine nucleotide exchange factor 1 isoform X9

    6. XM_054362780.1 → XP_054218755.1  rap guanine nucleotide exchange factor 1 isoform X1

    7. XM_054362786.1 → XP_054218761.1  rap guanine nucleotide exchange factor 1 isoform X8

    8. XM_054362782.1 → XP_054218757.1  rap guanine nucleotide exchange factor 1 isoform X3

    9. XM_054362790.1 → XP_054218765.1  rap guanine nucleotide exchange factor 1 isoform X12

    10. XM_054362789.1 → XP_054218764.1  rap guanine nucleotide exchange factor 1 isoform X11

    11. XM_054362791.1 → XP_054218766.1  rap guanine nucleotide exchange factor 1 isoform X13

    12. XM_054362795.1 → XP_054218770.1  rap guanine nucleotide exchange factor 1 isoform X17

    13. XM_054362792.1 → XP_054218767.1  rap guanine nucleotide exchange factor 1 isoform X14

    14. XM_054362793.1 → XP_054218768.1  rap guanine nucleotide exchange factor 1 isoform X15

    15. XM_054362796.1 → XP_054218771.1  rap guanine nucleotide exchange factor 1 isoform X18

    16. XM_054362794.1 → XP_054218769.1  rap guanine nucleotide exchange factor 1 isoform X16

    17. XM_054362785.1 → XP_054218760.1  rap guanine nucleotide exchange factor 1 isoform X7

    18. XM_054362797.1 → XP_054218772.1  rap guanine nucleotide exchange factor 1 isoform X19

    19. XM_054362798.1 → XP_054218773.1  rap guanine nucleotide exchange factor 1 isoform X20

    20. XM_054362799.1 → XP_054218774.1  rap guanine nucleotide exchange factor 1 isoform X21

    21. XM_054362800.1 → XP_054218775.1  rap guanine nucleotide exchange factor 1 isoform X22

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13905.3 GenPept UniProtKB/Swiss-Prot:Q13905

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