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    MGST2 microsomal glutathione S-transferase 2 [ Homo sapiens (human) ]

    Gene ID: 4258, updated on 2-Nov-2024

    Summary

    Official Symbol
    MGST2provided by HGNC
    Official Full Name
    microsomal glutathione S-transferase 2provided by HGNC
    Primary source
    HGNC:HGNC:7063
    See related
    Ensembl:ENSG00000085871 MIM:601733; AllianceGenome:HGNC:7063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GST2; MGST-II
    Summary
    The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in liver (RPKM 15.9), small intestine (RPKM 13.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MGST2 in Genome Data Viewer
    Location:
    4q31.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (139665819..139754618)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (142985421..143074258)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (140586973..140661899)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377622 Neighboring gene Sharpr-MPRA regulatory region 6908 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:140586532-140587731 Neighboring gene QKI interacting lncRNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21930 Neighboring gene RN7SK pseudogene 237 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:140632274-140633473 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:140661600-140662100 Neighboring gene H3 histone pseudogene 16 Neighboring gene uncharacterized LOC124900781 Neighboring gene mastermind like transcriptional coactivator 3 Neighboring gene uncharacterized LOC124900782

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ27438, MGC14097

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme activator activity  
    enables glutathione binding PubMed 
    enables glutathione peroxidase activity  
    enables glutathione peroxidase activity PubMed 
    enables glutathione transferase activity  
    enables glutathione transferase activity PubMed 
    enables identical protein binding PubMed 
    enables identical protein binding PubMed 
    enables leukotriene-C4 synthase activity  
    enables leukotriene-C4 synthase activity PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in intracellular membrane-bounded organelle PubMed 
    located_in membrane PubMed 
    is_active_in nuclear envelope  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    microsomal glutathione S-transferase 2
    Names
    glutathione peroxidase MGST2
    leukotriene C4 synthase MGST2
    microsomal GST-2
    microsomal GST-II
    microsomal glutathione S-transferase II
    NP_001191295.1
    NP_001191296.1
    NP_001191297.1
    NP_002404.1
    XP_016863700.1
    XP_016863701.1
    XP_016863702.1
    XP_047271657.1
    XP_054206024.1
    XP_054206025.1
    XP_054206026.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204366.2NP_001191295.1  microsomal glutathione S-transferase 2 isoform 1

      See identical proteins and their annotated locations for NP_001191295.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 3' UTR and encodes the same isoform (1), as compared to variant 1.
      Source sequence(s)
      AC108053, AC112236
      Consensus CDS
      CCDS3749.1
      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
      Related
      ENSP00000482639.1, ENST00000616265.4
      Conserved Domains (1) summary
      pfam01124
      Location:8111
      MAPEG; MAPEG family
    2. NM_001204367.2NP_001191296.1  microsomal glutathione S-transferase 2 isoform 2

      See identical proteins and their annotated locations for NP_001191296.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' region, which results in a downstream AUG start codon, and has an alternate 3' UTR, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC108053, AC112236
      Related
      ENST00000515137.5
    3. NM_001204368.2NP_001191297.1  microsomal glutathione S-transferase 2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001191297.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 3' region, which results in frame-shift, as compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC108053, AC112236
      Consensus CDS
      CCDS56339.1
      UniProtKB/Swiss-Prot
      Q99735
      Related
      ENSP00000424278.1, ENST00000506797.5
    4. NM_002413.5NP_002404.1  microsomal glutathione S-transferase 2 isoform 1

      See identical proteins and their annotated locations for NP_002404.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is a predominant transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC108053, AC112236
      Consensus CDS
      CCDS3749.1
      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
      Related
      ENSP00000265498.1, ENST00000265498.6
      Conserved Domains (1) summary
      pfam01124
      Location:8111
      MAPEG; MAPEG family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      139665819..139754618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008211.3XP_016863700.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
      Conserved Domains (1) summary
      pfam01124
      Location:8111
      MAPEG; MAPEG family
    2. XM_047415701.1XP_047271657.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
    3. XM_017008212.3XP_016863701.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
      Related
      ENSP00000423008.1, ENST00000503816.1
      Conserved Domains (1) summary
      pfam01124
      Location:8111
      MAPEG; MAPEG family
    4. XM_017008213.2XP_016863702.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
      Conserved Domains (1) summary
      pfam01124
      Location:8111
      MAPEG; MAPEG family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      142985421..143074258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350049.1XP_054206024.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
    2. XM_054350050.1XP_054206025.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
    3. XM_054350051.1XP_054206026.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
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