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    NEU3 neuraminidase 3 [ Homo sapiens (human) ]

    Gene ID: 10825, updated on 3-Nov-2024

    Summary

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    Official Symbol
    NEU3provided by HGNC
    Official Full Name
    neuraminidase 3provided by HGNC
    Primary source
    HGNC:HGNC:7760
    See related
    Ensembl:ENSG00000162139 MIM:604617; AllianceGenome:HGNC:7760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIAL3
    Summary
    This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 5.8), prostate (RPKM 5.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NEU3 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (74980515..75020676)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (74910079..74957510)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74699689..74721952)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene X-ray radiation resistance associated 1 Neighboring gene uncharacterized LOC107984352 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:74644275-74644750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:74659504-74660358 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:74660359-74661213 Neighboring gene signal peptidase complex subunit 2 Neighboring gene RNA, U6 small nuclear 216, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5261 Neighboring gene olfactory receptor family 2 subfamily AT member 2 pseudogene Neighboring gene nucleophosmin 1 pseudogene 50

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Substrate recognition of the membrane-associated sialidase NEU3 requires a hydrophobic aglycone. Sandbhor MS, et al. Biochemistry, 2011 Aug 16. PMID 21675735
    2. Upregulation of sialidase NEU3 in head and neck squamous cell carcinoma associated with lymph node metastasis. Shiga K, et al. Cancer Sci, 2015 Nov. PMID 26470851, Free PMC Article
    3. Role of plasma-membrane-bound sialidase NEU3 in clathrin-mediated endocytosis. Rodriguez-Walker M, et al. Biochem J, 2015 Aug 15. PMID 26251452
    4. Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression. Kakugawa Y, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12149448, Free PMC Article
    5. Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling. Takahashi K, et al. Int J Cancer, 2015 Oct 1. PMID 25810027

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3.
      Title: EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3.
    2. The extracellular sialidase NEU3 primes neutrophils.
      Title: The extracellular sialidase NEU3 primes neutrophils.
    3. Sialidase NEU3 and its pathological significance.
      Title: Sialidase NEU3 and its pathological significance.
    4. Reduced Sialylation and Bioactivity of the Antifibrotic Protein Serum Amyloid P in the Sera of Patients with Idiopathic Pulmonary Fibrosis.
      Title: Reduced Sialylation and Bioactivity of the Antifibrotic Protein Serum Amyloid P in the Sera of Patients with Idiopathic Pulmonary Fibrosis.
    5. TGF-beta1 increases sialidase 3 expression in human lung epithelial cells by decreasing its degradation and upregulating its translation.
      Title: TGF-β1 increases sialidase 3 expression in human lung epithelial cells by decreasing its degradation and upregulating its translation.
    6. Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines.
      Title: Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines.
    7. Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation.
      Title: Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation.
    8. overexpression of NEU3 in glioblastoma U87MG cells activates the PI3K/Akt signaling pathway resulting in an increased radioresistance capacity and in an improved efficiency of double strand DNA-repair mechanisms after irradiation
      Title: Overexpression of sialidase NEU3 increases the cellular radioresistance potential of U87MG glioblastoma cells.
    9. this finding strongly supports the idea that Neu3 may contain a cytosolic-exposed domain.
      Title: Human Sialidase Neu3 is S-Acylated and Behaves Like an Integral Membrane Protein.
    10. This first demonstration of sialidase involvement in invasive potential of gliolastoma cells may point to NEU3 as an attractive treatment target of human gliomas
      Title: Sialidase NEU3 defines invasive potential of human glioblastoma cells by regulating calpain-mediated proteolysis of focal adhesion proteins.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Removal of sialic acids from HIV-1 gp120 with neuraminidase (NA) enhances mannose-binding lectin (MBL) binding PubMed
    env The desialylation of HIV-1 gp120 with neuraminidase greatly augments the initial virus-cell interaction, leading to remarkably enhanced viral replication and cytopathogenicity PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12388

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-sialidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables exo-alpha-sialidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exo-alpha-sialidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables exo-alpha-sialidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exo-alpha-sialidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables exo-alpha-sialidase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ganglioside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ganglioside catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycosphingolipid catabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of clathrin-dependent endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sialidase-3
    Names
    N-acetyl-alpha-neuraminidase 3
    ganglioside sialidase
    ganglioside sialidasedis
    membrane sialidase
    sialidase 3 (membrane sialidase)
    NP_001354789.1
    NP_001354790.1
    NP_001354791.1
    NP_001354792.1
    NP_001354793.1
    NP_001354794.1
    NP_001354795.1
    NP_001354796.1
    NP_006647.3
    XP_047282254.1
    XP_047282255.1
    XP_047282256.1
    XP_047282257.1
    XP_047282258.1
    XP_047282259.1
    XP_047282260.1
    XP_054223493.1
    XP_054223494.1
    XP_054223495.1
    XP_054223496.1
    XP_054223497.1
    XP_054223498.1
    XP_054223499.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001367860.1 → NP_001354789.1  sialidase-3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variant 1, encodes the longest isoform (a).
      Source sequence(s)
      AP001992, BC136397
      Consensus CDS
      CCDS44682.1
      UniProtKB/Swiss-Prot
      A8K327, Q9NQE1, Q9UQ49
      Related
      ENSP00000432097.1, ENST00000531509.5

    2. NM_001367861.1 → NP_001354790.1  sialidase-3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variant 4, encodes isoform b.
      Source sequence(s)
      AP001992
      Consensus CDS
      CCDS91538.1
      UniProtKB/TrEMBL
      E9PNK1
      Conserved Domains (1) summary
      cd15482
      Location:44 → 93
      Sialidase_non-viral; Non-viral sialidases

    3. NM_001367862.1 → NP_001354791.1  sialidase-3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variant 3, encodes isoform b.
      Source sequence(s)
      AP001992, DB099096
      Consensus CDS
      CCDS91538.1
      UniProtKB/TrEMBL
      E9PNK1
      Related
      ENSP00000434754.1, ENST00000534628.1
      Conserved Domains (1) summary
      cd15482
      Location:44 → 93
      Sialidase_non-viral; Non-viral sialidases

    4. NM_001367863.1 → NP_001354792.1  sialidase-3 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 6, encodes isoform c.
      Source sequence(s)
      AP001992
      Consensus CDS
      CCDS91539.1
      UniProtKB/TrEMBL
      E9PMZ3
      Related
      ENSP00000434474.1, ENST00000529024.1

    5. NM_001367864.1 → NP_001354793.1  sialidase-3 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 5, encodes isoform c.
      Source sequence(s)
      AK303540, AP001992
      Consensus CDS
      CCDS91539.1
      UniProtKB/TrEMBL
      E9PMZ3
      Related
      ENSP00000434907.1, ENST00000532963.1

    6. NM_001367865.1 → NP_001354794.1  sialidase-3 isoform d

      Status: REVIEWED

      Source sequence(s)
      AP001992

    7. NM_001367866.1 → NP_001354795.1  sialidase-3 isoform e

      Status: REVIEWED

      Source sequence(s)
      AP001992, BP352846
      Consensus CDS
      CCDS91537.1
      UniProtKB/TrEMBL
      E9PR25
      Related
      ENSP00000436118.1, ENST00000531619.1
      Conserved Domains (1) summary
      cd15482
      Location:44 → 126
      Sialidase_non-viral; Non-viral sialidases

    8. NM_001367867.2 → NP_001354796.1  sialidase-3 isoform f

      Status: REVIEWED

      Source sequence(s)
      AP001992, BX108543
      Consensus CDS
      CCDS91536.1
      UniProtKB/TrEMBL
      E9PI40
      Related
      ENSP00000436540.1, ENST00000526068.1

    9. NM_006656.6 → NP_006647.3  sialidase-3 isoform a

      See identical proteins and their annotated locations for NP_006647.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AP001992, CN429425, DB240271
      Consensus CDS
      CCDS44682.1
      UniProtKB/Swiss-Prot
      A8K327, Q9NQE1, Q9UQ49
      Related
      ENSP00000294064.4, ENST00000294064.9
      Conserved Domains (2) summary
      cd15482
      Location:44 → 436
      Sialidase_non-viral; Non-viral sialidases
      pfam13088
      Location:70 → 417
      BNR_2; BNR repeat-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      74980515..75020676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426298.1 → XP_047282254.1  sialidase-3 isoform X1

    2. XM_047426304.1 → XP_047282260.1  sialidase-3 isoform X5

    3. XM_047426303.1 → XP_047282259.1  sialidase-3 isoform X4

    4. XM_047426302.1 → XP_047282258.1  sialidase-3 isoform X4

    5. XM_047426301.1 → XP_047282257.1  sialidase-3 isoform X3

      UniProtKB/TrEMBL
      B4E0V4

    6. XM_047426300.1 → XP_047282256.1  sialidase-3 isoform X3

      UniProtKB/TrEMBL
      B4E0V4

    7. XM_047426299.1 → XP_047282255.1  sialidase-3 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      74910079..74957510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367518.1 → XP_054223493.1  sialidase-3 isoform X1

    2. XM_054367524.1 → XP_054223499.1  sialidase-3 isoform X5

    3. XM_054367523.1 → XP_054223498.1  sialidase-3 isoform X4

    4. XM_054367522.1 → XP_054223497.1  sialidase-3 isoform X4

    5. XM_054367521.1 → XP_054223496.1  sialidase-3 isoform X3

      UniProtKB/TrEMBL
      B4E0V4

    6. XM_054367520.1 → XP_054223495.1  sialidase-3 isoform X3

      UniProtKB/TrEMBL
      B4E0V4

    7. XM_054367519.1 → XP_054223494.1  sialidase-3 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UQ49.1 GenPept UniProtKB/Swiss-Prot:Q9UQ49

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