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    CMTM4 CKLF like MARVEL transmembrane domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 146223, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CMTM4provided by HGNC
    Official Full Name
    CKLF like MARVEL transmembrane domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:19175
    See related
    Ensembl:ENSG00000183723 MIM:607887; AllianceGenome:HGNC:19175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKLFSF4
    Summary
    This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in thyroid (RPKM 48.0), kidney (RPKM 20.0) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CMTM4 in Genome Data Viewer
    Location:
    16q21-q22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (66598178..66696743, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72359915..72491037, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66648653..66730646, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CKLF-CMTM1 readthrough Neighboring gene CKLF like MARVEL transmembrane domain containing 1 Neighboring gene CKLF like MARVEL transmembrane domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66642903-66643714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66653785-66654286 Neighboring gene CKLF like MARVEL transmembrane domain containing 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:66677635-66677813 Neighboring gene Sharpr-MPRA regulatory region 8452 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:66708833-66709036 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:66710611-66711112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66725551-66726230 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66726231-66726910 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66726911-66727590 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:66729849-66730688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7566 Neighboring gene dynein cytoplasmic 1 light intermediate chain 2 Neighboring gene MPRA-validated peak2616 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:66785153-66785868 Neighboring gene DYNC1LI2 divergent transcript Neighboring gene telomere repeat binding bouquet formation protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through Inducing G2/M phase accumulation. Plate M, et al. Mol Cells, 2010 Apr. PMID 20213316
    2. Prognostic significance and immune characteristics of CMTM4 in hepatocellular carcinoma. Tan S, et al. BMC Cancer, 2022 Aug 19. PMID 35986302, Free PMC Article
    3. CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma. Li T, et al. J Exp Clin Cancer Res, 2015 Oct 16. PMID 26474560, Free PMC Article
    4. Inhibition of CMTM4 Sensitizes Cholangiocarcinoma and Hepatocellular Carcinoma to T Cell-Mediated Antitumor Immunity Through PD-L1. Chui NN, et al. Hepatol Commun, 2022 Jan. PMID 34558800, Free PMC Article
    5. CMTM4 inhibits cell proliferation and migration via AKT, ERK1/2, and STAT3 pathway in colorectal cancer. Xue H, et al. Acta Biochim Biophys Sin (Shanghai), 2019 Sep 6. PMID 31435638

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prognostic significance of RKIP, TGM2, and CMTM4 expression in oral squamous cell carcinoma.
      Title: Prognostic significance of RKIP, TGM2, and CMTM4 expression in oral squamous cell carcinoma.
    2. CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology.
      Title: CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology.
    3. Analysis of CMTM6 and CMTM4 expression as potential regulators of the PD-L1 protein and its association with prognosis in glioma cancer.
      Title: Analysis of CMTM6 and CMTM4 expression as potential regulators of the PD-L1 protein and its association with prognosis in glioma cancer.
    4. Prognostic significance and immune characteristics of CMTM4 in hepatocellular carcinoma.
      Title: Prognostic significance and immune characteristics of CMTM4 in hepatocellular carcinoma.
    5. CMTM6 and CMTM4 as two novel regulators of PD-L1 modulate the tumor microenvironment.
      Title: CMTM6 and CMTM4 as two novel regulators of PD-L1 modulate the tumor microenvironment.
    6. Exosomal miR-224-5p from Colorectal Cancer Cells Promotes Malignant Transformation of Human Normal Colon Epithelial Cells by Promoting Cell Proliferation through Downregulation of CMTM4.
      Title: Exosomal miR-224-5p from Colorectal Cancer Cells Promotes Malignant Transformation of Human Normal Colon Epithelial Cells by Promoting Cell Proliferation through Downregulation of CMTM4.
    7. CircCYP24A1 hampered malignant phenotype of renal cancer carcinoma through modulating CMTM-4 expression via sponging miR-421.
      Title: CircCYP24A1 hampered malignant phenotype of renal cancer carcinoma through modulating CMTM-4 expression via sponging miR-421.
    8. Inhibition of CMTM4 Sensitizes Cholangiocarcinoma and Hepatocellular Carcinoma to T Cell-Mediated Antitumor Immunity Through PD-L1.
      Title: Inhibition of CMTM4 Sensitizes Cholangiocarcinoma and Hepatocellular Carcinoma to T Cell-Mediated Antitumor Immunity Through PD-L1.
    9. Pancreatic stellate cells derived exosomal miR-5703 promotes pancreatic cancer by downregulating CMTM4 and activating PI3K/Akt pathway.
      Title: Pancreatic stellate cells derived exosomal miR-5703 promotes pancreatic cancer by downregulating CMTM4 and activating PI3K/Akt pathway.
    10. CMTM4 plays an important role in the turnover of membrane-bound VE-cadherin at AJs, mediating endothelial barrier function and controlling vascular sprouting.
      Title: CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CKLF-like MARVEL transmembrane domain-containing protein 4
    Names
    chemokine-like factor super family 4
    chemokine-like factor superfamily member 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178818.3 → NP_848933.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_848933.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC018557, AF521889
      Consensus CDS
      CCDS10817.1
      UniProtKB/Swiss-Prot
      Q52M40, Q8IZR4, Q8IZR5, Q8IZV1
      Related
      ENSP00000333833.4, ENST00000330687.8
      Conserved Domains (1) summary
      pfam01284
      Location:49 → 170
      MARVEL; Membrane-associating domain

    2. NM_181521.3 → NP_852662.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_852662.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an additional segment in the 3' coding region that leads to an upstream stop codon, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AC018557, AF479814, AW207043
      Consensus CDS
      CCDS42170.1
      UniProtKB/Swiss-Prot
      Q8IZR5
      Related
      ENSP00000377666.2, ENST00000394106.7
      Conserved Domains (1) summary
      pfam01284
      Location:49 → 170
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      66598178..66696743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022954.2 → XP_016878443.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X1

    2. XM_011522882.2 → XP_011521184.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X2

      See identical proteins and their annotated locations for XP_011521184.1

      UniProtKB/Swiss-Prot
      Q8IZR5
      Related
      ENSP00000456380.1, ENST00000563952.1
      Conserved Domains (1) summary
      pfam01284
      Location:34 → 141
      MARVEL; Membrane-associating domain

    RNA

    1. XR_933209.3 RNA Sequence

    2. XR_933210.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      72359915..72491037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379651.1 → XP_054235626.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X3

    2. XM_054379652.1 → XP_054235627.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X4

    3. XM_054379653.1 → XP_054235628.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X5

    4. XM_054379654.1 → XP_054235629.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X6

    5. XM_054379655.1 → XP_054235630.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X1

    6. XM_054379656.1 → XP_054235631.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X2

    RNA

    1. XR_008489057.1 RNA Sequence

    2. XR_008489058.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZR5.1 GenPept UniProtKB/Swiss-Prot:Q8IZR5

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