FBXO21 F-box protein 21 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FBXO21provided by HGNC
Official Full Name: F-box protein 21provided by HGNC
Primary source: HGNC:HGNC:13592
See related: Ensembl:ENSG00000135108 MIM:609095; AllianceGenome:HGNC:13592
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FBX21
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 31.4), ovary (RPKM 26.9) and 25 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12q24.22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (117141991..117190470, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (117123006..117171512, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (117579796..117628275, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FBXO21 mediated degradation of p85alpha regulates proliferation and survival of acute myeloid leukemia.
Title: FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.
circRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis.
Title: circRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis.
JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy.
Title: JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy.
Ser291-phosphorylated form of the multifunctional protein and stem cell marker, CD44, inhibits FBXO21-directed degradation of P-gp.
Title: CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination.
SCF(FBXO21) polyubiquitylates EID1 both in vitro and in vivo and is required for the efficient degradation of EID1 in both cycling and quiescent cells.
Title: Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.
The results suggest that EID1 is a bona fide substrate of FBXO21 and that the control of EID1 abundance by SCF(FBXO)(21) might affect the transcriptional repression activity of EID1.
Title: FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction	Pubs
Knockdown of F-box protein 21 (FBXO21) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

G64759 (e-PCR)
- UniSTS:164711

WI-20357 (e-PCR)
- UniSTS:80234

WI-21497 (e-PCR)
- UniSTS:83326

RH15672 (e-PCR)
- UniSTS:86657

STS-T56610 (e-PCR)
- UniSTS:44203

RH93520 (e-PCR)
- UniSTS:89523

RH47471 (e-PCR)
- UniSTS:63957

D12S2147 (e-PCR)
- UniSTS:43756

FBXO21_1269 (e-PCR)
- UniSTS:277229

Clone Names

FLJ90233, KIAA0875, MGC26682, DKFZp434G058

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in ubiquitin-dependent protein catabolic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
part_of ubiquitin ligase complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: F-box only protein 21

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015002.3 → NP_055817.1 F-box only protein 21 isoform 2

See identical proteins and their annotated locations for NP_055817.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks a 21 nt fragment within the coding region, and thus encodes a 7 aa shorter isoform than variant 1.

Source sequence(s)

AB020682, AC026368, BC034045, BC042333, BI550121

Consensus CDS

CCDS44989.1

UniProtKB/TrEMBL

Q4G104

Related

ENSP00000483508.1, ENST00000622495.5

Conserved Domains (3) summary

TIGR02097
Location:493 → 590

yccV; hemimethylated DNA binding domain

smart00256
Location:33 → 74

FBOX; A Receptor for Ubiquitination Targets

pfam13369
Location:215 → 388

Transglut_core2; Transglutaminase-like superfamily
NM_033624.3 → NP_296373.1 F-box only protein 21 isoform 1

See identical proteins and their annotated locations for NP_296373.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) contains an additional 21 nt fragment within the coding region, and thus encodes a 7 aa longer isoform than variant 2.

Source sequence(s)

AB020682, AC026368, AL136899, BC034045, BC042333, BI550121

Consensus CDS

CCDS9184.1

UniProtKB/Swiss-Prot

B3KMF0, O94952, Q5BJG0, Q9H087

UniProtKB/TrEMBL

Q4G104

Related

ENSP00000328187.5, ENST00000330622.9

Conserved Domains (3) summary

TIGR02097
Location:500 → 597

yccV; hemimethylated DNA binding domain

smart00256
Location:33 → 74

FBOX; A Receptor for Ubiquitination Targets

pfam13369
Location:215 → 388

Transglut_core2; Transglutaminase-like superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

117141991..117190470 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017019038.3 → XP_016874527.1 F-box only protein 21 isoform X2

UniProtKB/TrEMBL

H0YIE9

Related

ENSP00000449264.1, ENST00000550180.5

Conserved Domains (3) summary

TIGR02097
Location:433 → 530

yccV; hemimethylated DNA binding domain

smart00256
Location:33 → 74

FBOX; A Receptor for Ubiquitination Targets

COG2912
Location:252 → 331

SirB1; Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal transduction mechanisms]
XM_017019037.3 → XP_016874526.1 F-box only protein 21 isoform X1

UniProtKB/TrEMBL

H0YIE9