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    YLPM1 YLP motif containing 1 [ Homo sapiens (human) ]

    Gene ID: 56252, updated on 14-Nov-2024

    Summary

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    Official Symbol
    YLPM1provided by HGNC
    Official Full Name
    YLP motif containing 1provided by HGNC
    Primary source
    HGNC:HGNC:17798
    See related
    Ensembl:ENSG00000119596 MIM:619766; AllianceGenome:HGNC:17798
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZAP3; ZAP113; PPP1R169; C14orf170
    Summary
    Enables RNA binding activity. Predicted to be involved in regulation of telomere maintenance. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 14.0), brain (RPKM 9.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See YLPM1 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74763316..74837318)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68972425..69046421)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75230019..75304021)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene apoptosis resistant E3 ubiquitin protein ligase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8729 Neighboring gene FCF1 rRNA-processing protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8730 Neighboring gene uncharacterized LOC105370569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8731 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:75321384-75322583 Neighboring gene uncharacterized LOC124903348 Neighboring gene prospero homeobox 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G. Ulke-Lemée A, et al. Biochim Biophys Acta, 2007 Oct. PMID 17890166
    2. A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Armstrong L, et al. Mech Dev, 2004 Dec. PMID 15511642
    3. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Sherrington R, et al. Nature, 1995 Jun 29. PMID 7596406
    4. Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes. Linkermann A, et al. Biochim Biophys Acta, 2009 Feb. PMID 19041431
    5. FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis. Mulkearns EE, et al. Mol Biol Cell, 2012 Apr. PMID 22323290, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZAP3 is a putative nucleoside kinase that targets protein phosphatase-1 through its highly conserved carboxy-terminal RVRW sequence.
      Title: The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    YLP motif-containing protein 1
    Names
    nuclear protein ZAP3
    protein phosphatase 1, regulatory subunit 169

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411052.1 → NP_001397981.1  YLP motif-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC007956
      Consensus CDS
      CCDS91906.1
      UniProtKB/TrEMBL
      F8VU51
      Related
      ENSP00000447921.1, ENST00000552421.5

    2. NM_019589.3 → NP_062535.2  YLP motif-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_062535.2

      Status: VALIDATED

      Source sequence(s)
      AC007956, AK090435, AK095760, BC007792, BX102033, DB096717
      Consensus CDS
      CCDS45135.1
      UniProtKB/Swiss-Prot
      P49750, P49752, Q96I64, Q9P1V7
      UniProtKB/TrEMBL
      Q8NF45
      Related
      ENSP00000324463.7, ENST00000325680.12
      Conserved Domains (3) summary
      cl25887
      Location:1279 → 1403
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl26098
      Location:1836 → 1971
      AAA_33; AAA domain
      cl28310
      Location:1085 → 1327
      Rho; Transcription termination factor Rho [Transcription]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      74763316..74837318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536966.3 → XP_011535268.1  YLP motif-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      Q8NF45
      Related
      ENSP00000449860.1, ENST00000549293.5
      Conserved Domains (1) summary
      pfam13671
      Location:1431 → 1566
      AAA_33; AAA domain

    2. XM_047431591.1 → XP_047287547.1  YLP motif-containing protein 1 isoform X2

    3. XM_005267860.4 → XP_005267917.1  YLP motif-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005267917.1

      UniProtKB/TrEMBL
      Q8NF45
      Conserved Domains (1) summary
      pfam13671
      Location:1836 → 1971
      AAA_33; AAA domain

    4. XM_047431592.1 → XP_047287548.1  YLP motif-containing protein 1 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      68972425..69046421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376401.1 → XP_054232376.1  YLP motif-containing protein 1 isoform X3

    2. XM_054376400.1 → XP_054232375.1  YLP motif-containing protein 1 isoform X2

    3. XM_054376399.1 → XP_054232374.1  YLP motif-containing protein 1 isoform X1

    4. XM_054376402.1 → XP_054232377.1  YLP motif-containing protein 1 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49750.4 GenPept UniProtKB/Swiss-Prot:P49750

    Gene LinkOut

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