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Links from PubChem Substance
- Official
Symbol
- CCL13provided by HGNC
- Official
Full Name
- C-C motif chemokine ligand 13provided by HGNC
- Primary source
-
HGNC:HGNC:10611
- See related
-
Ensembl:ENSG00000181374
MIM:601391;
AllianceGenome:HGNC:10611
- Gene type
- protein coding
- RefSeq status
- REVIEWED
- Organism
-
Homo sapiens
- Lineage
- Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
- Also known as
- NCC1; CKb10; MCP-4; NCC-1; SCYL1; SCYA13
- Summary
- This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]
- Expression
- Broad expression in colon (RPKM 14.2), small intestine (RPKM 11.9) and 14 other tissues See more
- Orthologs
-
all
-
NEW
-
Try the new Gene table
Try the new Transcript table
- Exon count:
- 3
Annotation release |
Status |
Assembly |
Chr
|
Location |
RS_2024_08 |
current |
GRCh38.p14 (GCF_000001405.40) |
17 |
NC_000017.11 (34356480..34358610) |
RS_2024_08 |
current |
T2T-CHM13v2.0 (GCF_009914755.1) |
17 |
NC_060941.1 (35303463..35305593) |
RS_2024_09 |
previous assembly |
GRCh37.p13 (GCF_000001405.25) |
17 |
NC_000017.10 (32683499..32685629) |
Chromosome 17 - NC_000017.11
- Project title: HPA RNA-seq normal tissues
HPA RNA-seq normal tissues
- Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
- BioProject: PRJEB4337
- Publication:
PMID 24309898
- Analysis date: Wed Apr 4 07:08:55 2018
-
CCL13 and human diseases.
Li L, et al. Front Immunol, 2023. PMID 37153575, Free PMC Article
-
Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin.
Uguccioni M, et al. J Exp Med, 1996 May 1. PMID 8642349, Free PMC Article
-
Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3.
Garcia-Zepeda EA, et al. J Immunol, 1996 Dec 15. PMID 8955214
-
Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2.
Godiska R, et al. J Leukoc Biol, 1997 Mar. PMID 9060459
-
Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines.
Hein H, et al. Biochem Biophys Res Commun, 1999 Feb 16. PMID 10049733
See all (61) citations in PubMed
What's a GeneRIF?
-
MCP-4 and Eotaxin-3 Are Novel Biomarkers for Chronic Obstructive Pulmonary Disease.
Title: MCP-4 and Eotaxin-3 Are Novel Biomarkers for Chronic Obstructive Pulmonary Disease.
-
CCL13 and human diseases.
Title: CCL13 and human diseases.
-
In plasma, but not CSF, the bivariate MCP4 (CCL13)/ MCP1(CCL2) ratio is ca. twofold elevated in PTSD patients compared with healthy controls.
Title: The MCP-4/MCP-1 ratio in plasma is a candidate circadian biomarker for chronic post-traumatic stress disorder.
-
The reduction of circulating levels of MCP-4, eotaxin-3, and MIP-1beta could be one of the mechanisms by which bariatric surgery contributes to the reduction of cardiovascular risk in these patients.
Title: Circulating Levels of the Adipokines Monocyte Chemotactic Protein-4 (MCP-4), Macrophage Inflammatory Protein-1β (MIP-1β), and Eotaxin-3 in Severe Obesity and Following Bariatric Surgery.
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CCL13 expression is significantly upregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.
-
CCL13 levels in serum and synovial fluid may serve as a biomarker for the progression of osteoarthritis.
Title: Association of CCL13 levels in serum and synovial fluid with the radiographic severity of knee osteoarthritis.
-
identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3, CCL4/CCL4L1/CCL4L2, CD160, IFNG, NR4A3 and XCL1/XCL2) were analyzed in 127 kidney biopsies
Title: Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection.
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CCL13 is an antimicrobial protein with bacteriocidal activity against E. coli.
Title: Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.
-
Data suggest that CCL13 binds to several chemokine receptors (CCR1, CCR2, and CCR3), allowing CCL13 to elicit different effects on target cells of immune system. CCL13 is involved in pathology of chronic inflammatory/autoimmune diseases. [REVIEW]
Title: The multiple faces of CCL13 in immunity and inflammation.
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MCP-4 and hsCRP may be the markers linking chronic inflammation in obesity and periodontal disease.
Title: Correlation of MCP-4 and high-sensitivity C-reactive protein as a marker of inflammation in obesity and chronic periodontitis.
Products |
Interactant |
Other Gene |
Complex |
Source |
Pubs |
Description |
- Preferred Names
- C-C motif chemokine 13
- Names
- CK-beta-10
- chemokine (C-C motif) ligand 13
- monocyte chemoattractant protein 4
- monocyte chemotactic protein 4
- new CC chemokine 1
- small inducible cytokine subfamily A (Cys-Cys), member 13
- small-inducible cytokine A13
NEW
Try the new Transcript table
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000017.11 Reference GRCh38.p14 Primary Assembly
- Range
-
34356480..34358610
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060941.1 Alternate T2T-CHM13v2.0
- Range
-
35303463..35305593
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.
Molecular Biology Databases
- Bgee database
- BioGPS
- BioGRID Open Repository of CRISPR Screens (ORCS)
- Domain Mapping of Disease Mutations
- Eukaryotic Promoter Database
- GlyGen glycoinformatics resource
- Human eFP Browser
- Ingenuity Pathways Analysis
- InnateDB
- InterMine
- Kyoto Encyclopedia of Genes and Genomes
- OMA Browser: Orthologous MAtrix
- OrthoDB catalog of orthologs
- PhosphoSitePlus
- The Weizmann Institute of Science GeneCards and MalaCards databases
Research Materials
- Addgene Non-profit plasmid repository
- Bio-Techne
- Creative Biogene
- ExactAntigen/Labome
- GenScript latest version of gene cDNA ORF Clone
- GeneCopoeia Inc.
- GeneTex Inc
- Kazusa DNA Research Institute
- OriGene