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    slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100487508, updated on 4-Nov-2024

    Summary

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    Official Symbol
    slc8a3provided by Xenbase
    Official Full Name
    solute carrier family 8 (sodium/calcium exchanger), member 3provided by Xenbase
    Primary source
    Xenbase:XB-GENE-954537
    See related
    Ensembl:ENSXETG00000002216 AllianceGenome:Xenbase:XB-GENE-954537
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    ncx3
    Summary
    Predicted to enable calcium:sodium antiporter activity; calmodulin binding activity; and metal ion binding activity. Predicted to act upstream of or within cell communication; metal ion transport; and transmembrane transport. Predicted to be located in plasma membrane. Orthologous to human SLC8A3 (solute carrier family 8 member A3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See slc8a3 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 8 NC_030684.2 (107336488..107480829)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 8 NC_030684.1 (87029982..87181206)

    Chromosome 8 - NC_030684.2Genomic Context describing neighboring genes Neighboring gene desumoylating isopeptidase 2 like Neighboring gene cytochrome c oxidase assembly factor COX16 Neighboring gene SPARC related modular calcium binding 1 Neighboring gene serine/arginine-rich splicing factor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global patterns of diversification in the history of modern amphibians. Roelants K, et al. Proc Natl Acad Sci U S A, 2007 Jan 16. PMID 17213318, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium:sodium antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodium/calcium exchanger 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      107336488..107480829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004917257.4 → XP_004917314.1  sodium/calcium exchanger 3 isoform X1

      UniProtKB/TrEMBL
      A0A6I8SWX1, A0A6I8T1Y7
      Related
      ENSXETP00000097496.2, ENSXETT00000096845.2
      Conserved Domains (5) summary
      smart00237
      Location:523 → 612
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:1 → 924
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:751 → 915
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:394 → 484
      Calx-beta; Calx-beta domain
      pfam16494
      Location:252 → 373
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    2. XM_004917258.4 → XP_004917315.1  sodium/calcium exchanger 3 isoform X2

      UniProtKB/TrEMBL
      A0A6I8T1Y7, A0A8J0R754
      Conserved Domains (1) summary
      TIGR00845
      Location:1 → 923
      caca; sodium/calcium exchanger 1

    3. XM_004917260.4 → XP_004917317.1  sodium/calcium exchanger 3 isoform X5

      UniProtKB/TrEMBL
      A0A6I8T1Y7, A0A8J0R2H9
      Related
      ENSXETP00000100656.1, ENSXETT00000069286.2
      Conserved Domains (1) summary
      TIGR00845
      Location:1 → 917
      caca; sodium/calcium exchanger 1

    4. XM_004917259.4 → XP_004917316.1  sodium/calcium exchanger 3 isoform X3

      UniProtKB/TrEMBL
      A0A6I8Q9H8, A0A7D9NLV5
      Related
      ENSXETP00000066206.2, ENSXETT00000073384.2
      Conserved Domains (4) summary
      TIGR00845
      Location:1 → 923
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:750 → 914
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:394 → 484
      Calx-beta; Calx-beta domain
      pfam16494
      Location:252 → 373
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    5. XM_002936886.5 → XP_002936932.1  sodium/calcium exchanger 3 isoform X4

      UniProtKB/TrEMBL
      A0A7D9NLV5, A0A8J0QT17
      Conserved Domains (1) summary
      TIGR00845
      Location:1 → 922
      caca; sodium/calcium exchanger 1

    6. XM_004917261.4 → XP_004917318.1  sodium/calcium exchanger 3 isoform X6

      UniProtKB/TrEMBL
      A0A7D9NLV5, A0A8J0R678
      Related
      ENSXETP00000004716.4, ENSXETT00000004716.5
      Conserved Domains (1) summary
      TIGR00845
      Location:1 → 916
      caca; sodium/calcium exchanger 1

    7. XM_031891155.1 → XP_031747015.1  sodium/calcium exchanger 3 isoform X8

      UniProtKB/TrEMBL
      A0A803K9H7, A0A8J1IQK0
      Conserved Domains (1) summary
      TIGR00845
      Location:29 → 317
      caca; sodium/calcium exchanger 1

    8. XM_004917263.4 → XP_004917320.1  sodium/calcium exchanger 3 isoform X7

      UniProtKB/TrEMBL
      A0A803K9H7, A0A8J0R6S3
      Conserved Domains (2) summary
      pfam01699
      Location:175 → 339
      Na_Ca_ex; Sodium/calcium exchanger protein
      cl02522
      Location:14 → 36
      Calx-beta; Calx-beta domain

    9. XM_012969528.3 → XP_012824982.1  sodium/calcium exchanger 3 isoform X9

      UniProtKB/TrEMBL
      A0A803K9H7, A0A8J0SXH0
      Related
      ENSXETP00000116896.1, ENSXETT00000111043.1
      Conserved Domains (1) summary
      pfam01699
      Location:133 → 297
      Na_Ca_ex; Sodium/calcium exchanger protein
    Nucleotide Protein Strain
    Heading Accession and Version

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