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    lys4 putative homocitrate synthase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539815, updated on 17-May-2024

    Summary

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    Gene symbol
    lys4
    Gene description
    putative homocitrate synthase
    Primary source
    PomBase:SPBC1105.02c
    Locus tag
    SPBC1105.02c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See lys4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3505708..3507472, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene PSP1 family protein Neighboring gene putative rRNA-processing Rrp12-like protein Neighboring gene putative mitochondrial ribosomal protein subunit L16 Neighboring gene protein tam12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis. Bulfer SL, et al. J Biol Chem, 2009 Dec 18. PMID 19776021, Free PMC Article
    2. Structural basis for L-lysine feedback inhibition of homocitrate synthase. Bulfer SL, et al. J Biol Chem, 2010 Apr 2. PMID 20089861, Free PMC Article
    3. Inactivation of homocitrate synthase causes lysine auxotrophy in copper/zinc-containing superoxide dismutase-deficient yeast Schizosaccharomyces pombe. Kwon ES, et al. J Biol Chem, 2006 Jan 20. PMID 16299000
    4. Lysine biosynthesis pathway and biochemical blocks of lysine auxotrophs of Schizosaccharomyces pombe. Ye ZH, et al. J Bacteriol, 1988 Dec. PMID 3142867, Free PMC Article
    5. Six new amino acid-auxotrophic markers for targeted gene integration and disruption in fission yeast. Ma Y, et al. Curr Genet, 2007 Aug. PMID 17622533

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
      Title: Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
    2. A putative homocitrate synthase, encoded by the lys4 gene, is a labile target of oxidative stress caused by copper/zinc-containing superoxide dismutase depletion. Its synthesis is positively regulated by Phx1, a putative transcriptional regulator.
      Title: Inactivation of homocitrate synthase causes lysine auxotrophy in copper/zinc-containing superoxide dismutase-deficient yeast Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables homocitrate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables homocitrate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables homocitrate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lysine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lysine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysine biosynthetic process via aminoadipic acid EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in lysine biosynthetic process via aminoadipic acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysine biosynthetic process via aminoadipic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    putative homocitrate synthase
    NP_596458.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3505708..3507472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022377.2 → NP_596458.1  putative homocitrate synthase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596458.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9Y823
      Conserved Domains (1) summary
      cd07948
      Location:35 → 296
      DRE_TIM_HCS; Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain
    Nucleotide Protein
    Heading Accession and Version

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