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    POLY polyprotein;protein F [ Hepatitis C virus genotype 4 ]

    Gene ID: 11027168, updated on 18-Aug-2023

    Summary

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    Gene symbol
    POLY
    Gene description
    polyprotein;protein F
    Locus tag
    HCV4_gp1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Hepatitis C virus genotype 4 (subtype: 4a, isolate: ED43, nat-host: human; 33 years old)
    Lineage
    Viruses; Riboviria; Flaviviridae; Hepacivirus
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    Genomic context

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    Sequence:
    NC_009825.1 (280..9306)

    NC_009825.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009825.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of HCV genotype 4d infections in Kayseri, Turkey. Kayman T, et al. Turk J Med Sci, 2015. PMID 26281318
    2. The Core/E1 domain of hepatitis C virus genotype 4a in Egypt does not contain viral mutations or strains specific for hepatocellular carcinoma. Zhang X, et al. J Clin Virol, 2011 Dec. PMID 21925935, Free PMC Article
    3. Complete nucleotide sequence of a type 4 hepatitis C virus variant, the predominant genotype in the Middle East. Chamberlain RW, et al. J Gen Virol, 1997 Jun. PMID 9191927

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The frequency of genotype 4 hepatitis C virus (HCV) infections is significantly higher in Kayseri compared to other provinces in Turkey.
      Title: Characterization of HCV genotype 4d infections in Kayseri, Turkey.
    2. study concludes the Core/E1 domain of HCV genotype 4a in Egypt does not contain hepatocellular carcinoma -specific mutations or strains
      Title: The Core/E1 domain of hepatitis C virus genotype 4a in Egypt does not contain viral mutations or strains specific for hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    General protein information

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    Preferred Names
    polyprotein;protein F
    Names
    core protein
    E1 protein
    E2 protein
    p7 protein
    NS2 protein
    NS3 protease/helicase
    NS4A protein
    NS4B protein
    NS5A protein
    NS5B RNA-dependent RNA polymerase
    YP_009272634.1
    • -2/+1 frameshift protein F; position predicted based on homology to protein F/predicted ribosomal slippage site in HCV1 RefSeq NC_004102.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_009825.1 Reference assembly

      Range
      280..9306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_001469632.1 polyprotein [Hepatitis C virus genotype 4]

      See identical proteins and their annotated locations for YP_001469632.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O39929
      UniProtKB/TrEMBL
      D6P446
      Conserved Domains (15) summary
      pfam01001
      Location:1728 → 1921
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b
      pfam01539
      Location:195 → 382
      HCV_env; Hepatitis C virus envelope glycoprotein E1
      pfam01560
      Location:386 → 729
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
      pfam01543
      Location:2 → 115
      HCV_capsid; Hepatitis C virus capsid protein
      pfam08301
      Location:2068 → 2168
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam01542
      Location:116 → 190
      HCV_core; Hepatitis C virus core protein
      pfam12941
      Location:2179 → 2417
      HCV_NS5a_C; HCV NS5a protein C-terminal region
      cl38915
      Location:1362 → 1486
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
      pfam00998
      Location:2420 → 2931
      RdRP_3; Viral RNA dependent RNA polymerase
      pfam01006
      Location:1658 → 1711
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a
      pfam01506
      Location:1975 → 1996
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam01538
      Location:811 → 1005
      HCV_NS2; Hepatitis C virus non-structural protein NS2
      pfam02907
      Location:1057 → 1204
      Peptidase_S29; Hepatitis C virus NS3 protease
      pfam08300
      Location:2006 → 2067
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
      cl28899
      Location:1224 → 1366
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    2. YP_009272635.1 core protein

    3. YP_009272636.1 E1 protein

    4. YP_009272637.1 E2 protein

      Conserved Domains (1) summary
      pfam01560
      Location:3 → 346
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1

    5. YP_009272638.1 p7 protein

    6. YP_009272639.1 NS2 protein

    7. YP_009272640.1 NS3 protease/helicase

    8. YP_009272641.1 NS4A protein

    9. YP_009272642.1 NS4B protein

    10. YP_009272643.1 NS5A protein

    11. YP_009272644.1 NS5B RNA-dependent RNA polymerase

    12. YP_009272634.1 protein F [Hepatitis C virus genotype 4]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7U3RKF2, A0A859ASZ6
    Protein Accession Links
    GenPept Link UniProtKB Link
    CAA72338.1

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