PTPRS protein tyrosine phosphatase receptor type S [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTPRSprovided by HGNC
Official Full Name: protein tyrosine phosphatase receptor type Sprovided by HGNC
Primary source: HGNC:HGNC:9681
See related: Ensembl:ENSG00000105426 MIM:601576; AllianceGenome:HGNC:9681
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: R-PTP-S; PTPSIGMA; R-PTP-sigma
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Expression: Broad expression in fat (RPKM 30.9), brain (RPKM 23.8) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.3

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (5205508..5340812, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (5192102..5327425, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (5205519..5340823, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced PTPRS expression promotes epithelial-mesenchymal transition of Schwann cells in NF1-related plexiform neurofibromas.
Title: Reduced PTPRS expression promotes epithelial-mesenchymal transition of Schwann cells in NF1-related plexiform neurofibromas.
PTPRS is a novel marker for early Tau pathology and synaptic integrity in Alzheimer's disease.
Title: PTPRS is a novel marker for early Tau pathology and synaptic integrity in Alzheimer's disease.
High expression of protein tyrosine phosphatase receptor S (PTPRS) is an independent prognostic marker for cholangiocarcinoma.
Title: High expression of protein tyrosine phosphatase receptor S (PTPRS) is an independent prognostic marker for cholangiocarcinoma.
Identification of PTPRsigma-interacting proteins by proximity-labelling assay.
Title: Identification of PTPRσ-interacting proteins by proximity-labelling assay.
High PTPRS expression is associated with hepatocellular carcinoma progression.
Title: BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis.
PTPRS modulates ERK phosphorylation and subsequent translocation to the nucleus.
Title: PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation.
loss of PTPRS expression may predict an aggressive clinical course in ESCC patients. PTPRS may function as a tumor suppressor and play an important role in esophageal squamous cell carcinoma growth and metastasis
Title: Expression and clinical relations of protein tyrosine phosphatase receptor type S in esophageal squamous cell carcinoma.
Study identified several CpG sites and specifically several CpGs in the PTPRS and PER3 genes differentially methylated between obese and non-obese children, suggesting a role for DNA methylation concerning development of childhood obesity.
Title: PTPRS and PER3 methylation levels are associated with childhood obesity: results from a genome-wide methylation analysis.
interaction of receptor type of protein tyrosine phosphatase sigma (RPTPsigma) with a glycosaminoglycan library
Title: Interaction of receptor type of protein tyrosine phosphatase sigma (RPTPσ) with a glycosaminoglycan library.
Receptor protein tyrosine phosphatase sigma (RPTPsigma) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis.
Title: Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of PTPRS	PubMed
Knockdown of protein tyrosine phosphatase, receptor type, Sigma (PTPRS) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G60139 (e-PCR)
- UniSTS:137259

D19S233E (e-PCR)
- UniSTS:63575

SHGC-132497 (e-PCR)
- UniSTS:173930

RH66535 (e-PCR)
- UniSTS:78988

D19S233E (e-PCR)
- UniSTS:68494

D19S233E (e-PCR)
- UniSTS:147392

D19S1011 (e-PCR)
- UniSTS:32741

STS-N38920 (e-PCR)
- UniSTS:17901

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chondroitin sulfate binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparan sulfate proteoglycan binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in corpus callosum development	IEA Inferred from Electronic Annotation more info
involved_in establishment of endothelial intestinal barrier	IEA Inferred from Electronic Annotation more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of axon extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of axon regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of collateral sprouting	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interferon-alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of toll-like receptor 9 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in spinal cord development	IEA Inferred from Electronic Annotation more info
involved_in synaptic membrane adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trans-synaptic signaling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular exosome	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase S

Names: protein tyrosine phosphatase PTPsigma; receptor-type tyrosine-protein phosphatase sigma

NP_001380940.1

EC 3.1.3.48

NP_001380941.1

EC 3.1.3.48

NP_001380942.1

EC 3.1.3.48

NP_002841.3

EC 3.1.3.48

NP_570923.2

EC 3.1.3.48

NP_570924.2

EC 3.1.3.48

NP_570925.2

EC 3.1.3.48

XP_005259657.1

EC 3.1.3.48

XP_005259664.1

EC 3.1.3.48

XP_005259667.1

EC 3.1.3.48

XP_011526460.1

EC 3.1.3.48

XP_016882554.1

EC 3.1.3.48

XP_016882555.1

EC 3.1.3.48

XP_016882556.1

EC 3.1.3.48

XP_016882557.1

EC 3.1.3.48

XP_016882558.1

EC 3.1.3.48

XP_016882559.1

EC 3.1.3.48

XP_016882560.1

EC 3.1.3.48

XP_016882561.1

EC 3.1.3.48

XP_016882562.1

EC 3.1.3.48

XP_016882563.1

EC 3.1.3.48

XP_016882564.1

EC 3.1.3.48

XP_047295111.1

EC 3.1.3.48

XP_047295112.1

EC 3.1.3.48

XP_047295113.1

EC 3.1.3.48

XP_047295114.1

EC 3.1.3.48

XP_047295115.1

EC 3.1.3.48

XP_047295116.1

EC 3.1.3.48

XP_047295117.1

EC 3.1.3.48

XP_047295118.1

EC 3.1.3.48

XP_047295119.1

EC 3.1.3.48

XP_047295120.1

EC 3.1.3.48

XP_047295121.1

EC 3.1.3.48

XP_047295122.1

EC 3.1.3.48

XP_047295123.1

EC 3.1.3.48

XP_054177576.1

EC 3.1.3.48

XP_054177577.1

EC 3.1.3.48

XP_054177578.1

EC 3.1.3.48

XP_054177579.1

EC 3.1.3.48

XP_054177580.1

EC 3.1.3.48

XP_054177581.1

EC 3.1.3.48

XP_054177582.1

EC 3.1.3.48

XP_054177583.1

EC 3.1.3.48

XP_054177584.1

EC 3.1.3.48

XP_054177585.1

EC 3.1.3.48

XP_054177586.1

EC 3.1.3.48

XP_054177587.1

EC 3.1.3.48

XP_054177588.1

EC 3.1.3.48

XP_054177589.1

EC 3.1.3.48

XP_054177590.1

EC 3.1.3.48

XP_054177591.1

EC 3.1.3.48

XP_054177592.1

EC 3.1.3.48

XP_054177593.1

EC 3.1.3.48

XP_054177594.1

EC 3.1.3.48

XP_054177595.1

EC 3.1.3.48

XP_054177596.1

EC 3.1.3.48

XP_054177597.1

EC 3.1.3.48

XP_054177598.1

EC 3.1.3.48

XP_054177599.1

EC 3.1.3.48

XP_054177600.1

EC 3.1.3.48

XP_054177601.1

EC 3.1.3.48

XP_054177602.1

EC 3.1.3.48

XP_054177603.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033964.1 RefSeqGene

Range

4992..140296

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001394011.1 → NP_001380940.1 receptor-type tyrosine-protein phosphatase S isoform 5 precursor

Status: REVIEWED

Source sequence(s)

AC005335, AC005338, AC005788, AC005790, AC118535

Conserved Domains (7) summary

smart00408
Location:150 → 214

IGc2; Immunoglobulin C-2 Type

smart00409
Location:238 → 315

IG; Immunoglobulin

smart00410
Location:39 → 124

IG_like; Immunoglobulin like

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14625
Location:1348 → 1629

R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1

cd14627
Location:1631 → 1920

R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2

cd00096
Location:165 → 169

Ig; Ig strand C [structural motif]
NM_001394012.1 → NP_001380941.1 receptor-type tyrosine-protein phosphatase S isoform 6 precursor

Status: REVIEWED

Source sequence(s)

AC005335, AC005338, AC005788, AC005790, AC118535

Conserved Domains (7) summary

smart00408
Location:150 → 214

IGc2; Immunoglobulin C-2 Type

smart00409
Location:238 → 315

IG; Immunoglobulin

smart00410
Location:39 → 124

IG_like; Immunoglobulin like

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14625
Location:1341 → 1622

R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1

cd14627
Location:1624 → 1913

R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2

cd00096
Location:165 → 169

Ig; Ig strand C [structural motif]
NM_001394013.1 → NP_001380942.1 receptor-type tyrosine-protein phosphatase S isoform 7 precursor

Status: REVIEWED

Source sequence(s)

AC005335, AC005338, AC005788, AC005790, AC118535

Conserved Domains (8) summary

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14625
Location:1328 → 1609

R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1

cd14627
Location:1611 → 1900

R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam18861
Location:1186 → 1285

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:137 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
NM_002850.4 → NP_002841.3 receptor-type tyrosine-protein phosphatase S isoform 1 precursor

See identical proteins and their annotated locations for NP_002841.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AB209333, AC005335, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317

Consensus CDS

CCDS45930.1

UniProtKB/Swiss-Prot

O75255, O75870, Q13332, Q15718, Q16341, Q2M3R7

Related

ENSP00000262963.8, ENST00000262963.11

Conserved Domains (8) summary

cd05738
Location:152 → 235

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd05739
Location:259 → 327

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:1392 → 1647

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:141 → 234

IG_like; Immunoglobulin like

cd00047
Location:1418 → 1647

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:332 → 421

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cl11960
Location:32 → 120

Ig; Immunoglobulin domain
NM_130853.3 → NP_570923.2 receptor-type tyrosine-protein phosphatase S isoform 3 precursor

See identical proteins and their annotated locations for NP_570923.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.

Source sequence(s)

AB209333, AC005335, AC118535, BC029496, BC104812

Consensus CDS

CCDS12139.1

UniProtKB/TrEMBL

G8JL96

Related

ENSP00000467398.1, ENST00000592099.5

Conserved Domains (8) summary

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd05739
Location:246 → 314

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:945 → 1200

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:141 → 225

IG_like; Immunoglobulin like

cd00047
Location:971 → 1200

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cl11960
Location:32 → 120

Ig; Immunoglobulin domain
NM_130854.3 → NP_570924.2 receptor-type tyrosine-protein phosphatase S isoform 2 precursor

See identical proteins and their annotated locations for NP_570924.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.

Source sequence(s)

AB209333, AC005335, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317

Consensus CDS

CCDS12140.1

UniProtKB/Swiss-Prot

Q13332

UniProtKB/TrEMBL

Q59FX6, Q8NHS7

Related

ENSP00000465443.1, ENST00000588012.5

Conserved Domains (8) summary

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd05739
Location:246 → 314

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:1354 → 1609

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:141 → 225

IG_like; Immunoglobulin like

cd00047
Location:1380 → 1609

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cl11960
Location:32 → 120

Ig; Immunoglobulin domain
NM_130855.3 → NP_570925.2 receptor-type tyrosine-protein phosphatase S isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks three internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks three internal segments, as compared to isoform 1.

Source sequence(s)

AB209333, AC005335, AC118535, BC029496, BC104812, U35234

UniProtKB/TrEMBL

G8JL96

Conserved Domains (8) summary

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd05739
Location:250 → 318

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:949 → 1204

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:141 → 225

IG_like; Immunoglobulin like

cd00047
Location:975 → 1204

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:323 → 412

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cl11960
Location:32 → 120

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

5205508..5340812 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047439166.1 → XP_047295122.1 receptor-type tyrosine-protein phosphatase S isoform X19
XM_047439164.1 → XP_047295120.1 receptor-type tyrosine-protein phosphatase S isoform X17
XM_047439162.1 → XP_047295118.1 receptor-type tyrosine-protein phosphatase S isoform X16
XM_047439161.1 → XP_047295117.1 receptor-type tyrosine-protein phosphatase S isoform X9
XM_047439155.1 → XP_047295111.1 receptor-type tyrosine-protein phosphatase S isoform X3
XM_017027066.2 → XP_016882555.1 receptor-type tyrosine-protein phosphatase S isoform X1

UniProtKB/Swiss-Prot

Q13332
XM_005259610.2 → XP_005259667.1 receptor-type tyrosine-protein phosphatase S isoform X19

UniProtKB/TrEMBL

G8JL96

Conserved Domains (8) summary

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd05739
Location:246 → 314

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:941 → 1196

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:141 → 225

IG_like; Immunoglobulin like

cd00047
Location:967 → 1196

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cl11960
Location:32 → 120

Ig; Immunoglobulin domain
XM_047439163.1 → XP_047295119.1 receptor-type tyrosine-protein phosphatase S isoform X16
XM_005259607.3 → XP_005259664.1 receptor-type tyrosine-protein phosphatase S isoform X12

Conserved Domains (8) summary

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14625
Location:1328 → 1609

R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1

cd14627
Location:1611 → 1900

R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam18861
Location:1186 → 1285

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:137 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
XM_047439160.1 → XP_047295116.1 receptor-type tyrosine-protein phosphatase S isoform X9
XM_047439159.1 → XP_047295115.1 receptor-type tyrosine-protein phosphatase S isoform X7
XM_047439157.1 → XP_047295113.1 receptor-type tyrosine-protein phosphatase S isoform X4
XM_005259600.3 → XP_005259657.1 receptor-type tyrosine-protein phosphatase S isoform X3

See identical proteins and their annotated locations for XP_005259657.1

Conserved Domains (8) summary

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd05739
Location:246 → 314

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:1379 → 1634

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:141 → 225

IG_like; Immunoglobulin like

cd00047
Location:1405 → 1634

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cl11960
Location:32 → 120

Ig; Immunoglobulin domain
XM_047439165.1 → XP_047295121.1 receptor-type tyrosine-protein phosphatase S isoform X18
XM_017027075.2 → XP_016882564.1 receptor-type tyrosine-protein phosphatase S isoform X15

UniProtKB/TrEMBL

G8JL96
XM_017027074.2 → XP_016882563.1 receptor-type tyrosine-protein phosphatase S isoform X14

UniProtKB/TrEMBL

G8JL96
XM_017027072.2 → XP_016882561.1 receptor-type tyrosine-protein phosphatase S isoform X11
XM_047439158.1 → XP_047295114.1 receptor-type tyrosine-protein phosphatase S isoform X6
XM_017027069.2 → XP_016882558.1 receptor-type tyrosine-protein phosphatase S isoform X5
XM_017027071.2 → XP_016882560.1 receptor-type tyrosine-protein phosphatase S isoform X10
XM_017027068.2 → XP_016882557.1 receptor-type tyrosine-protein phosphatase S isoform X2
XM_017027070.2 → XP_016882559.1 receptor-type tyrosine-protein phosphatase S isoform X8
XM_017027065.2 → XP_016882554.1 receptor-type tyrosine-protein phosphatase S isoform X1

UniProtKB/Swiss-Prot

Q13332
XM_047439156.1 → XP_047295112.1 receptor-type tyrosine-protein phosphatase S isoform X3
XM_017027067.2 → XP_016882556.1 receptor-type tyrosine-protein phosphatase S isoform X1

UniProtKB/Swiss-Prot

Q13332
XM_017027073.2 → XP_016882562.1 receptor-type tyrosine-protein phosphatase S isoform X13
XM_047439167.1 → XP_047295123.1 receptor-type tyrosine-protein phosphatase S isoform X21
XM_011528158.3 → XP_011526460.1 receptor-type tyrosine-protein phosphatase S isoform X20

Conserved Domains (3) summary

smart00194
Location:601 → 856

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:627 → 856

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:141 → 238

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

5192102..5327425 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321626.1 → XP_054177601.1 receptor-type tyrosine-protein phosphatase S isoform X19
XM_054321623.1 → XP_054177598.1 receptor-type tyrosine-protein phosphatase S isoform X17
XM_054321621.1 → XP_054177596.1 receptor-type tyrosine-protein phosphatase S isoform X16
XM_054321614.1 → XP_054177589.1 receptor-type tyrosine-protein phosphatase S isoform X9
XM_054321606.1 → XP_054177581.1 receptor-type tyrosine-protein phosphatase S isoform X3
XM_054321601.1 → XP_054177576.1 receptor-type tyrosine-protein phosphatase S isoform X1
XM_054321622.1 → XP_054177597.1 receptor-type tyrosine-protein phosphatase S isoform X16
XM_054321602.1 → XP_054177577.1 receptor-type tyrosine-protein phosphatase S isoform X1
XM_054321624.1 → XP_054177599.1 receptor-type tyrosine-protein phosphatase S isoform X18
XM_054321620.1 → XP_054177595.1 receptor-type tyrosine-protein phosphatase S isoform X15
XM_054321619.1 → XP_054177594.1 receptor-type tyrosine-protein phosphatase S isoform X14
XM_054321616.1 → XP_054177591.1 receptor-type tyrosine-protein phosphatase S isoform X11
XM_054321610.1 → XP_054177585.1 receptor-type tyrosine-protein phosphatase S isoform X6
XM_054321609.1 → XP_054177584.1 receptor-type tyrosine-protein phosphatase S isoform X5
XM_054321615.1 → XP_054177590.1 receptor-type tyrosine-protein phosphatase S isoform X10
XM_054321604.1 → XP_054177579.1 receptor-type tyrosine-protein phosphatase S isoform X2
XM_054321612.1 → XP_054177587.1 receptor-type tyrosine-protein phosphatase S isoform X8
XM_054321625.1 → XP_054177600.1 receptor-type tyrosine-protein phosphatase S isoform X19
XM_054321617.1 → XP_054177592.1 receptor-type tyrosine-protein phosphatase S isoform X12
XM_054321613.1 → XP_054177588.1 receptor-type tyrosine-protein phosphatase S isoform X9
XM_054321611.1 → XP_054177586.1 receptor-type tyrosine-protein phosphatase S isoform X7
XM_054321608.1 → XP_054177583.1 receptor-type tyrosine-protein phosphatase S isoform X4
XM_054321605.1 → XP_054177580.1 receptor-type tyrosine-protein phosphatase S isoform X3
XM_054321607.1 → XP_054177582.1 receptor-type tyrosine-protein phosphatase S isoform X3
XM_054321603.1 → XP_054177578.1 receptor-type tyrosine-protein phosphatase S isoform X1
XM_054321618.1 → XP_054177593.1 receptor-type tyrosine-protein phosphatase S isoform X13
XM_054321628.1 → XP_054177603.1 receptor-type tyrosine-protein phosphatase S isoform X21
XM_054321627.1 → XP_054177602.1 receptor-type tyrosine-protein phosphatase S isoform X20