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    SYTL5 synaptotagmin like 5 [ Homo sapiens (human) ]

    Gene ID: 94122, updated on 5-May-2024

    Summary

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    Official Symbol
    SYTL5provided by HGNC
    Official Full Name
    synaptotagmin like 5provided by HGNC
    Primary source
    HGNC:HGNC:15589
    See related
    Ensembl:ENSG00000147041 AllianceGenome:HGNC:15589
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    slp5
    Summary
    The protein encoded by this gene belongs to the synaptotagmin-like (Slp) protein family, which contains a unique homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of this gene is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
    Expression
    Broad expression in stomach (RPKM 4.3), placenta (RPKM 2.5) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    Xp11.4
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (37888915..38128820)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (37292501..37532417)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (37865806..37988073)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20733 Neighboring gene dynein light chain Tctex-type 3 Neighboring gene RNA, U6 small nuclear 49, pseudogene Neighboring gene sterol-C4-methyl oxidase pseudogene Neighboring gene H2A.L variant histone 3 Neighboring gene H2A.P histone Neighboring gene microRNA 548aj-2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29521 Neighboring gene sushi repeat containing protein X-linked Neighboring gene uncharacterized LOC124905176

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SYTL5 Promotes Papillary Thyroid Carcinoma Progression by Enhancing Activation of the NF-κB Signaling Pathway. Huang D, et al. Endocrinology, 2022 Nov 14. PMID 36378561
    2. Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism. Saxena SK, et al. Biochem Biophys Res Commun, 2006 Jun 2. PMID 16630545
    3. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Kuroda TS, et al. Biochem Biophys Res Commun, 2002 May 10. PMID 12051743
    4. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Kerns SL, et al. Int J Radiat Oncol Biol Phys, 2010 Dec 1. PMID 20932654, Free PMC Article
    5. Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. Fukuda M. J Biol Chem, 2003 Apr 25. PMID 12590134

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SYTL5 Promotes Papillary Thyroid Carcinoma Progression by Enhancing Activation of the NF-kappaB Signaling Pathway.
      Title: SYTL5 Promotes Papillary Thyroid Carcinoma Progression by Enhancing Activation of the NF-κB Signaling Pathway.
    2. These observations decisively prove that Rab27a inhibits ENaC function through a complex mechanism that involves GTP/GDP status, and protein-protein interactions involving Munc13-4 and SLP-5 effector proteins.
      Title: Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism.
    3. molecular cloning of slp5:a novel Rab27A effector with C-terminal tandem C2 domains
      Title: Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains.
    4. Synaptotagmin-like protein 5 (Slp5) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp5 specifically and directly binds the GTP-bound form of Rab27A.
      Title: Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic variants associated with disordered eating.
    EBI GWAS Catalog
    Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • AL121578.2

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-like protein 5
    Names
    exophilin 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013265.2 RefSeqGene

      Range
      122640..244903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001163334.1 → NP_001156806.1  synaptotagmin-like protein 5 isoform 2

      See identical proteins and their annotated locations for NP_001156806.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an in-frame coding exon missing in variant 1, resulting in a longer isoform (2) with an additional 22 aa protein segment compared to isoform 1.
      Source sequence(s)
      AK125106, AL135038, BC131585, BX647688
      Consensus CDS
      CCDS55399.1
      UniProtKB/Swiss-Prot
      Q8TDW5
      Related
      ENSP00000395220.2, ENST00000456733.2
      Conserved Domains (5) summary
      cd04020
      Location:566 → 744
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:429 → 552
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      pfam15308
      Location:159 → 309
      CEP170_C; CEP170 C-terminus
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    2. NM_001163335.2 → NP_001156807.1  synaptotagmin-like protein 5 isoform 1

      See identical proteins and their annotated locations for NP_001156807.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AB080222, AK125106, AL121578, AL135038, BX647688
      Consensus CDS
      CCDS14244.1
      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5
      Conserved Domains (3) summary
      cd04020
      Location:544 → 722
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:407 → 530
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins

    3. NM_138780.3 → NP_620135.1  synaptotagmin-like protein 5 isoform 1

      See identical proteins and their annotated locations for NP_620135.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AB080222, AK125106, AL121578, AL135038, BX647688
      Consensus CDS
      CCDS14244.1
      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5
      Related
      ENSP00000297875.2, ENST00000297875.7
      Conserved Domains (3) summary
      cd04020
      Location:544 → 722
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:407 → 530
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      37888915..38128820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029972.1 → XP_016885461.1  synaptotagmin-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q8TDW5
      Conserved Domains (5) summary
      cd04020
      Location:566 → 744
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:429 → 552
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      pfam15308
      Location:159 → 309
      CEP170_C; CEP170 C-terminus
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    2. XM_047442658.1 → XP_047298614.1  synaptotagmin-like protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5

    3. XM_011544001.3 → XP_011542303.1  synaptotagmin-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011542303.1

      UniProtKB/Swiss-Prot
      Q8TDW5
      Conserved Domains (5) summary
      cd04020
      Location:566 → 744
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:429 → 552
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      pfam15308
      Location:159 → 309
      CEP170_C; CEP170 C-terminus
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    4. XM_047442654.1 → XP_047298610.1  synaptotagmin-like protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5

    5. XM_047442663.1 → XP_047298619.1  synaptotagmin-like protein 5 isoform X4

    6. XM_017029974.2 → XP_016885463.1  synaptotagmin-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q8TDW5
      Conserved Domains (5) summary
      cd04020
      Location:566 → 744
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:429 → 552
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      pfam15308
      Location:159 → 309
      CEP170_C; CEP170 C-terminus
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    7. XM_047442655.1 → XP_047298611.1  synaptotagmin-like protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5

    8. XM_047442669.1 → XP_047298625.1  synaptotagmin-like protein 5 isoform X5

    9. XM_047442660.1 → XP_047298616.1  synaptotagmin-like protein 5 isoform X4

    10. XM_047442652.1 → XP_047298608.1  synaptotagmin-like protein 5 isoform X1

    11. XM_047442657.1 → XP_047298613.1  synaptotagmin-like protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5

    12. XM_047442670.1 → XP_047298626.1  synaptotagmin-like protein 5 isoform X5

    13. XM_047442666.1 → XP_047298622.1  synaptotagmin-like protein 5 isoform X4

    14. XM_011544002.3 → XP_011542304.1  synaptotagmin-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011542304.1

      UniProtKB/Swiss-Prot
      Q8TDW5
      Conserved Domains (5) summary
      cd04020
      Location:566 → 744
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:429 → 552
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      pfam15308
      Location:159 → 309
      CEP170_C; CEP170 C-terminus
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    15. XM_047442656.1 → XP_047298612.1  synaptotagmin-like protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5

    16. XM_047442653.1 → XP_047298609.1  synaptotagmin-like protein 5 isoform X2

    17. XM_047442664.1 → XP_047298620.1  synaptotagmin-like protein 5 isoform X4

    18. XM_017029973.2 → XP_016885462.1  synaptotagmin-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q8TDW5
      Conserved Domains (5) summary
      cd04020
      Location:566 → 744
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:429 → 552
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      pfam15308
      Location:159 → 309
      CEP170_C; CEP170 C-terminus
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    19. XM_047442659.1 → XP_047298615.1  synaptotagmin-like protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5

    20. XM_047442665.1 → XP_047298621.1  synaptotagmin-like protein 5 isoform X4

    21. XM_047442667.1 → XP_047298623.1  synaptotagmin-like protein 5 isoform X4

    22. XM_047442662.1 → XP_047298618.1  synaptotagmin-like protein 5 isoform X4

    23. XM_047442668.1 → XP_047298624.1  synaptotagmin-like protein 5 isoform X5

    24. XM_047442661.1 → XP_047298617.1  synaptotagmin-like protein 5 isoform X4

    25. XM_047442671.1 → XP_047298627.1  synaptotagmin-like protein 5 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      37292501..37532417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328146.1 → XP_054184121.1  synaptotagmin-like protein 5 isoform X1

    2. XM_054328155.1 → XP_054184130.1  synaptotagmin-like protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5

    3. XM_054328153.1 → XP_054184128.1  synaptotagmin-like protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5

    4. XM_054328149.1 → XP_054184124.1  synaptotagmin-like protein 5 isoform X2

    5. XM_054328162.1 → XP_054184137.1  synaptotagmin-like protein 5 isoform X4

    6. XM_054328154.1 → XP_054184129.1  synaptotagmin-like protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5

    7. XM_054328145.1 → XP_054184120.1  synaptotagmin-like protein 5 isoform X1

    8. XM_054328158.1 → XP_054184133.1  synaptotagmin-like protein 5 isoform X4

    9. XM_054328147.1 → XP_054184122.1  synaptotagmin-like protein 5 isoform X1

    10. XM_054328159.1 → XP_054184134.1  synaptotagmin-like protein 5 isoform X4

    11. XM_054328150.1 → XP_054184125.1  synaptotagmin-like protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5

    12. XM_054328161.1 → XP_054184136.1  synaptotagmin-like protein 5 isoform X4

    13. XM_054328165.1 → XP_054184140.1  synaptotagmin-like protein 5 isoform X5

    14. XM_054328148.1 → XP_054184123.1  synaptotagmin-like protein 5 isoform X1

    15. XM_054328166.1 → XP_054184141.1  synaptotagmin-like protein 5 isoform X5

    16. XM_054328143.1 → XP_054184118.1  synaptotagmin-like protein 5 isoform X1

    17. XM_054328151.1 → XP_054184126.1  synaptotagmin-like protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5

    18. XM_054328163.1 → XP_054184138.1  synaptotagmin-like protein 5 isoform X4

    19. XM_054328160.1 → XP_054184135.1  synaptotagmin-like protein 5 isoform X4

    20. XM_054328152.1 → XP_054184127.1  synaptotagmin-like protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A2RRF2, Q8TDW5

    21. XM_054328144.1 → XP_054184119.1  synaptotagmin-like protein 5 isoform X1

    22. XM_054328157.1 → XP_054184132.1  synaptotagmin-like protein 5 isoform X4

    23. XM_054328164.1 → XP_054184139.1  synaptotagmin-like protein 5 isoform X5

    24. XM_054328156.1 → XP_054184131.1  synaptotagmin-like protein 5 isoform X4

    25. XM_054328167.1 → XP_054184142.1  synaptotagmin-like protein 5 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TDW5.1 GenPept UniProtKB/Swiss-Prot:Q8TDW5

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